Results 181 to 190 of about 526,926 (248)
Advanced Science, Volume 13, Issue 35, 24 June 2026.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Purification and properties of human alpha-galactosidases.
The Journal of biological chemistry, 1973 E, Beutler, W, Kuhl
openaire +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang +16 more
wiley +1 more source
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, Volume 13, Issue 32, 9 June 2026.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 31, 4 June 2026.The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu +11 more
wiley +1 more source
The Polymers of Life: Exploring Cellular Function Through Polymer Concepts
Advanced Science, Volume 13, Issue 33, 15 June 2026.Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley +1 more source
A 32‐Year‐Old Man With an Cardiomyopathy
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Scleredema is a sclerosing dermatosis of unknown etiology, characterized by non‐punctate, weakly infiltrated skin thickening and swelling, which can lead to the development of cardiomyopathy. Scleredema‐associated cardiomyopathy is at present poorly understood.
Yuting Zou, Shan Li, Tong Chen, Yi Li
wiley +1 more source
Nanoparticles in Vascular Dementia: Advantages and Challenges
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This review highlights the dual diagnostic and therapeutic potential of nanomaterials in Vascular Dementia (VaD). By effectively crossing the blood–brain barrier, functionalized nanoparticles facilitate early diagnosis by targeting Aβ deposits and vascular lesions.
Xianxin Liu +8 more
wiley +1 more source