Results 201 to 210 of about 118,748,616 (241)

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

A Novel Peptide Targeting the USP25–SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence

Aging Cell, Volume 25, Issue 11, November 2026.
USP25‐mediated K63‐linked deubiquitination of SIRT1 at K506 and K513 suppresses its activity to promote senescence. These findings unveil a novel aging regulatory axis and identify a peptide targeting the USP25–SIRT1 interaction for anti‐senescence therapeutic intervention.
YuJuan Zhou, Xinshu Wang, Jiyuan Zhang, Hanqiong Qiang, Xinru Zhao, Jingyi Luo, Yanjun Ji, Jiakai Yao, Linhui Zhai, Tingting Zhang, Ke Li, Yuping Chen, Jian Yuan, Lei Li, Yunhui Li   +14 more
wiley   +1 more source

High Resolution Ion Mobility Enables the Separation of α-Galactose Containing Glycans from Their Non-α-Galactose Isomers. [PDF]

J Biomol Tech
Park K, Orlando R.
europepmc   +1 more source

Endothelial Matrin‐3 Limits Cellular Senescence and Lipid Dysregulation to Protect Against Murine Atherosclerosis

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Endothelial Matrin‐3 suppresses cellular senescence and protects against atherosclerosis. Matrin‐3 deficiency induces endothelial senescence, mitochondrial dysfunction, and activation of p53‐, cell cycle‐, and senescence‐related pathways. In atherosclerosis‐prone mice, endothelial Matrin‐3 deletion promotes atherosclerotic lesion formation and disrupts
Xiao Cheng, Fatema Yeasmin Tanni, Rachelle Nelson Zoni, Elham Abdollahi, Eli Childs, Xinghui Sun   +5 more
wiley   +1 more source

Fabry Disease Diagnosed With Lung Nodule: A Unique Presentation in a Young Female Patient. [PDF]

Cureus
Joppich J, Mehta S, Mandavilli N, Rojas Alvarez F, Mehta V.   +4 more
europepmc   +1 more source

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +2 more sources

Long-Term Cardiac Remodeling During Migalastat Therapy in a Heterozygote Woman With Fabry Disease (N224S): A 9 Year Case Report. [PDF]

Am J Case Rep
Tan C, Thanabalasingam V, Sella Kapu C, Hiskens M, Zhang Z.   +4 more
europepmc   +1 more source

Renal involvement in Fabry disease from Tunisian families: Six case reports. [PDF]

World J Nephrol
Tlili S, Ghabi H, Mami I, Ben Hmida F, Rais L, Zouaghi MK.   +5 more
europepmc   +1 more source

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources