Results 201 to 210 of about 286,880 (314)

Flow Cytometry-Based Assay to Detect Alpha Galactosidase Enzymatic Activity at the Cellular Level. [PDF]

Cells
Fekete N, Li LK, Kozma GT, Fekete G, Pállinger É, Kovács ÁF.   +5 more
europepmc   +1 more source

Cardiovascular manifestations of Fabry disease: relationships between left ventricular hypertrophy, disease severity, and alpha-galactosidase A activity.

European Heart Journal, 2010
Justina C. Wu, Carolyn Y. Ho, H. Skali, R. Abichandani, W. Wilcox, M. Banikazemi, S. Packman, K. Sims, S. Solomon   +8 more
semanticscholar   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Pegunigalsidase alfa: a novel, pegylated recombinant alpha-galactosidase enzyme for the treatment of Fabry disease. [PDF]

Front Genet
Germain DP, Linhart A.
europepmc   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, Volume 13, Issue 21, 13 April 2026.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Biodegradation of sugarcane bagasse biomass using recombinant alpha-galactosidase overexpressing whole-cell <i>E.coli</i>: a sustainable method of agricultural waste utilization. [PDF]

3 Biotech
Vetriselvi PM, Narasimhan MK, Samuel M, Arunraj R.   +3 more
europepmc   +1 more source

Endothelial NAD+ depletion drives vascular senescence and neuroinflammation via mtDNA‐cGAS/STING‐CD38 signaling in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract BACKGROUND Endothelial dysfunction has emerged as early and pivotal event in Alzheimer's disease (AD), yet the molecular mechanisms linking vascular aging to neuroinflammation remain elusive. METHODS We used APP/PS1 mice and amyloid beta (Aβ)–challenged brain endothelial cells (BECs) to understand the mechanisms of nicotinamide adenine ...
Qing‐Hua Luo, Fang Li, Li Yang, Han‐Qing Pan, Wen‐Ping Zhu, Ping Hu, Chu‐Ming Tao, Min Yin, Si Zhang, Qiu‐Ye Liao, Zhi‐Hao Chen, Hong‐Xin Shu, Xin‐Yi Zhu, Teng‐Feng Yan, Xu Liu, Jiang‐Long Tu, Xin‐Gen Zhu   +16 more
wiley   +1 more source

Diagnosis of Fabry Disease Using Alpha-Galactosidase A Activity or LysoGb3 in Blood Fails to Identify Up to Two Thirds of Female Patients. [PDF]

Int J Mol Sci
Duro G, Anania M, Zizzo C, Francofonte D, Giacalone I, D'Errico A, Marsana EM, Colomba P.   +7 more
europepmc   +1 more source

Challenging popular tools for the annotation of genetic variations with a real case, pathogenic mutations of lysosomal alpha-galactosidase. [PDF]

BMC Bioinformatics, 2018
Cimmaruta C, Citro V, Andreotti G, Liguori L, Cubellis MV, Hay Mele B.   +5 more
europepmc   +1 more source