Results 211 to 220 of about 118,748,616 (241)

A Contemporary Pathomechanistic Nosology of Inherited Lysosomal Disorders. [PDF]

J Inherit Metab Dis
McCarron EP, Blau N, Eden ER, Platt FM, Aerts JM, Jones SA, Ferreira CR, Stepien KM.   +7 more
europepmc   +1 more source

α-Mangostin attenuates <i>Pseudomonas aeruginosa</i> virulence by targeting PqsR and inhibiting PQS-mediated quorum sensing. [PDF]

Virulence
Liu D, Li Z, Cheng J, Xiao W, Zheng Y, Liu G, Zeng J, Li S, Wang Z, Wang Y, Mao R, Cao D, Lin J.   +12 more
europepmc   +1 more source

Genomic Characterization of the Probiotic <i>Limosilactobacillus mucosae</i> CRL2069 Isolated from Feedlot Cattle Feces. [PDF]

Microorganisms
Aristimuño Ficoseco CM, Carrasco N, Montemurro M, Chieffi D, Fadda SG, Nader-Macias MEF, Fusco V, Vignolo GM, Fanelli F.   +8 more
europepmc   +1 more source

<i>Rhodoglobus galactosidasius</i> sp. nov., a psychrophilic <i>Actinomycetota</i> producing a cold-active β-galactosidase isolated from Cape Hallett, Antarctica. [PDF]

Int J Syst Evol Microbiol
Cattaneo A, Leone L, Romano I, Pannico M, Nicolaus B, Di Donato P, Poli A, Finore I.   +7 more
europepmc   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, Volume 15, Issue 38, 16 October 2026.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Hypertrophic Phenotype in an Adolescent from the Amazon Region Associated with Combined Variants in the GLA, TTR, and PRKAG2 genes. [PDF]

Arq Bras Cardiol
Monteiro MM, Silva KFD, Ortiz JV, Ferreira MLB, Couceiro KDN, Castro RF, Fernandes F, Ferreira JMBB, Investigadores do Mapa Genoma Brasil, Investigadores do Mapa Genoma Brasil, Linnenkamp BDW, Marques EL, Krieger JE.   +12 more
europepmc   +1 more source

Impact of migalastat therapy on corneal deposits in a female with Fabry disease: A case report. [PDF]

Mol Genet Metab Rep
Vitturi N, Gugelmo G, Zanini F, Carraro G, Lenzini L, Leonardi A.   +5 more
europepmc   +1 more source

Screening of fabry disease in patients with left ventricular hypertrophy: a single-center study in Mexico. [PDF]

Orphanet J Rare Dis
Palacios Gutierrez D, Meléndez-Ramirez G, Posada Martínez EL, Ibarra-Ibarra BR, Koretzky SG, Escalante Seyffert MC, Roldán Gómez FJ, Gonzalez Ramirez AM, Sabido González LM, Vera Ibarra D, Ortiz Herrera JL, Vázquez Fernández K, Ramirez de Jesús D, Berrios Barcenas EA.   +13 more
europepmc   +1 more source

Unraveling skeletal muscle senescence in an <i>in vitro</i> cell culture model. [PDF]

Front Aging
Bagri KM, Lima Castelo-Branco MT, Mermelstein C.   +2 more
europepmc   +1 more source