Results 241 to 250 of about 114,325,321 (319)

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Human α-galactosidase A is stimulated by folic acid supplementation - possible implications in Fabry disease management. [PDF]

PLoS One
Khatoon S, Junaid MA.
europepmc   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni, Maria Luisa Di Paolo, Antonio Laghezza, Giorgio Cozza, Francesco Piazzola, Laura Facci, Emma Marcolin, Elena Roggiolani, Luca Piemontese, Anna Minarini, Morena Zusso, Lisa Dalla Via, Michela Rosini   +12 more
wiley   +1 more source

Decellularized Extracellular Matrix Mitigates the Senescent Phenotype and Restores Osteogenic Potential in Human Mesenchymal Stromal Cells. [PDF]

J Orthop Res
Dorais CJ, Kruger NM, Ramos-Rodriguez DH, Lee MA, Kent Leach J.   +4 more
europepmc   +1 more source

Screening for Fabry Disease Among Dialysis Patients: A Multicenter Cross-Sectional Study in Türkiye with Cascade Screening of Identified Cases. [PDF]

Medicina (Kaunas)
Atılgan KG, Aylı BI, Aylı MD.
europepmc   +1 more source

Could Fabry Disease Cause Giant Coronary Aneurysms in a 7-Month-Old Infant: A Case Report. [PDF]

Clin Case Rep
Shabanian R, Dadkhah M, Doroudian R, Adib M, Naderi S, Ashkboos K.   +5 more
europepmc   +1 more source

<i>Staphylococcus dromedarii</i> sp. nov., isolated from dromedary (<i>Camelus dromedarius</i>). [PDF]

Int J Syst Evol Microbiol
Kuhnert P, Brodard I, Jores J.
europepmc   +1 more source

Diagnostic and therapeutic applications of the glycan biomarker H3N2b in GM1 Gangliosidosis. [PDF]

Mol Genet Metab
Kell P, Mishra S, D'Souza P, Tifft CJ, Dietzen DJ, Lasio LD, Carson JP, Hong X, Schiffmann R, Ledesma MD, Tayebi N, Dickson PI, Porter FD, Ory DS, Jiang X.   +14 more
europepmc   +1 more source

Automated quantification of skin Gb3 load and white matter lesion assessment in Fabry disease. [PDF]

Orphanet J Rare Dis
Pfister C, Schindehütte M, Erbacher C, Klein T, Rost S, Lang AC, Pham M, Nordbeck P, Wanner C, Sommer C, Üçeyler N.   +10 more
europepmc   +1 more source