Results 231 to 240 of about 286,880 (314)

Sequence‐Based and Functional Analysis for the Discovery of N‐Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This research offers valuable understanding of how N‐glycans are broken down by the gut microbiota of infants, focusing on glycoside hydrolase families GH2, GH20, and GH18. It reveals that the gut microbiota of breastfed infants has a diverse array of genes coding for these enzymes.
Irene Boscá‐Sánchez, Jesús Rodríguez‐Díaz, María J. Yebra   +2 more
wiley   +1 more source

Case report of a 45-year old female Fabry disease patient carrying two alpha-galactosidase A gene mutation alleles. [PDF]

BMC Med Genet, 2016
Oder D, Vergho D, Ertl G, Wanner C, Nordbeck P.   +4 more
europepmc   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, Volume 40, Issue 4, Page 1970-2002, April 2026.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Unveiling the Hidden Drivers: How Vegetation Cover, Season and Forest Management Shape the Soil Microbial Community in Two Mediterranean Forest Ecosystems

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Forest management affects microbial community composition depending on forest type. Vegetation type has the strongest effect on microbial composition, while management alters community structure without affecting function, highlighting the importance of vegetation in forest soil ecosystem dynamics.
Enrica Picariello, Flavia De Nicola
wiley   +1 more source

Interactions of Mucus Monosaccharides and the Epidermal Microbiome in Four Benthic Elasmobranchs

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Here we collected mucus and microbes from the skin of Elasmobranchs to identify interactions between mucus and the microbial community. We identified key microbial genes involved in the metabolism of mucus carbohydrates in Elasmobranchs. ABSTRACT Epidermal mucus is a complicated mixture of macromolecules which acts as the first line of defence for ...
Emma N. Kerr, Long Yu, Ryan D. Hesse, Chloe N. Roberts, Vincent Bulone, Lauren Meyer, Robert A. Edwards, Michael P. Doane, Elizabeth A. Dinsdale   +8 more
wiley   +1 more source

Senescence‐Driven IL‐17A Inflammatory Circuit Promotes Epithelial–Mesenchymal Transition (EMT) and Progression in Age‐Related Posterior Subcapsular Cataracts

Aging Cell, Volume 25, Issue 4, April 2026.
Using multi‐region human PSC samples, we identified EMT as a consistent pathological feature. Mechanistically, senescent LECs secrete IL‐17A, a representative SASP factor, which activates NF‐κB signaling. NF‐κB further amplifies SASP production, thereby establishing a senescence–inflammation feedback loop that drives EMT, sustains pathological ...
Yan Ni, Yu Ma, Zewen Ren, Yi Zhu, Liangping Liu, Runping Duan, Lu Qin, Yang Chen, Rong Ju, Yingyan Qin, Mingxing Wu   +10 more
wiley   +1 more source

High throughput screening for inhibitors of alpha-galactosidase. [PDF]

Curr Chem Genomics, 2010
Motabar O, Liu K, Southall N, Marugan JJ, Goldin E, Sidransky E, Zheng W.   +6 more
europepmc   +1 more source

MicroRNA‐128‐3p Deficiency Alleviates Bone Loss in Age‐Related Osteoporosis via Activation of Canonical Wnt Signaling

Aging Cell, Volume 25, Issue 4, April 2026.
Working model: MiR‐128‐3p inhibited the canonical Wnt signaling pathway by targeting Dvl2, resulting in reduced OB differentiation and age‐related osteoporosis. ABSTRACT MicroRNA‐128‐3p (miR‐128‐3p) has emerged as a crucial regulator of the aging process and age‐associated disorders. Recent research highlights the vital role of miR‐128‐3p in osteoclast
Gengyang Shen, Kun Chen, Qi Shang, Honglin Chen, Yu Liu, Guifeng Chen, Weicheng Qin, Jiahui He, Yuzhuo Zhang, Wenhua Zhao, Weiyu Qiu, Jingzhi Zhang, Hui Ren, Xiaobing Jiang   +13 more
wiley   +1 more source

Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in Adipocytes

Aging Cell, Volume 25, Issue 4, April 2026.
Phosphoenolpyruvate carboxykinase 1 (Pck1) expression is downregulated in aging white adipose tissue. Adipocyte Pck1 deficiency impairs TCA cycle cataplerosis, causing fumarate accumulation. Excess fumarate disrupts mitochondrial homeostasis, triggers oxidative stress and mtDNA release, activating cGAS–STING signaling and driving inflammaging ...
Yiting Lei, Meng Yang, Xiaoyun Jiang, Yujie Zhang, Yuzhi Chen, Weiheng Xie, Qihui Dai, Weihong Qin, Xiuqin Deng, Xiaojun Zhang, Zhongjun Zhou, Gonghua Huang, Xinguang Liu   +12 more
wiley   +1 more source

Double‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration

Aging Cell, Volume 25, Issue 4, April 2026.
A novel drug combination (NMN + API) promotes musculoskeletal regeneration in aging. By boosting NAD+, it activates SIRT3 to suppress cellular senescence and enhance differentiation into chondrocytes, osteoblasts, and myocytes. Oral administration reshapes the gut microbiota, increasing production of the anti‐aging metabolite PHS.
Jianfeng Yu, Mingzhuang Hou, Yaoge Deng, Chenqi Yu, Yang Liu, Kang Kang, Xiaowei Xia, Xiaoping Li, Huilin Yang, Dinghua Jiang, Wu Xu, Yijian Zhang, Xuesong Zhu   +12 more
wiley   +1 more source