Results 231 to 240 of about 114,325,321 (319)

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

α-Mangostin attenuates <i>Pseudomonas aeruginosa</i> virulence by targeting PqsR and inhibiting PQS-mediated quorum sensing. [PDF]

Virulence
Liu D, Li Z, Cheng J, Xiao W, Zheng Y, Liu G, Zeng J, Li S, Wang Z, Wang Y, Mao R, Cao D, Lin J.   +12 more
europepmc   +1 more source

ADSC‐Derived CCL8 Regulates HIF‐1α Signaling and Promotes Colorectal Cancer Progression in a 3D Coculture Platform

Cancer Science, Volume 117, Issue 9, Page 2480-2495, September 2026.
Schematic illustration showing how CRC‐associated ADSC‐derived CCL8 promotes colorectal cancer cell migration through ERK/HIF‐1α signaling in a 3D coculture platform. ABSTRACT This study aimed to recapitulate adipose‐tumor interactions within the colorectal cancer (CRC) tumor microenvironment (TME) and to elucidate the role of adipose‐derived stem ...
Jeong‐Eun Yun, Yeseon Son, Jieun Seo, Ki Yong Hong, Junji Fukuda, Do‐Won Jeong, Jong‐Wan Park, Yang‐Sook Chun   +7 more
wiley   +1 more source

Impact of migalastat therapy on corneal deposits in a female with Fabry disease: A case report. [PDF]

Mol Genet Metab Rep
Vitturi N, Gugelmo G, Zanini F, Carraro G, Lenzini L, Leonardi A.   +5 more
europepmc   +1 more source

Mechanism of action of alpha-galactosidase.

Indian journal of biochemistry & biophysics, 1988
C D, Mathew, K, Balasubramaniam
openaire   +1 more source

Effects of a Dietary Supplement on Systemic Aging Related Biomarkers and Skin Aging Outcomes in Middle‐Aged Women: In Vitro and Clinical Studies

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Interest in dietary supplements targeting both skin and biological aging biomarkers is rapidly growing, yet existing studies lack rigorous clinical validation of combined oral–topical regimens and concurrent assessment of skin and systemic biomarkers.
Jie‐Hua Chen, Liugang Ding, Pingping Lv, Wenzhi Li, Meiling Tai, Ran Yin, Yi Yu, Yunru Huang, Jinluan Zheng, Erman Wang, Huan Liu, Jiaojiao Fu, Hongjue Wang, Ruopan Huang, Jun Ma   +14 more
wiley   +1 more source

GmERF109 Positively Enhances Soybean Resistance to Phytophthora sojae by Transcriptionally Activating GmG4DT‐Like to Promote Glyceollin I Accumulation

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
GmERF109 is strongly induced in P. sojae‐resistant but not susceptible soybeans. GmERF109 functions as a nuclear AP2/ERF transcription factor, P. sojae directly binding the GCC‐box to activate GmG4DT‐like expression. The GmERF109–GmG4DT‐like module enhances glyceollin I accumulation for soybean resistance to P. sojae.
Xin Fang, Rui Liang, Yiling Cheng, Hong Gao, Chuanzhong Zhang, Jingcan Sun, Junjun Song, Gengpu Zhang, Meng Liu, Yuxin Zhao, Yan Sun, Xiran Wang, Xiaoyu Chen, Kexin Ma, Shuo Wang, Kexin Li, Jiapeng Tong, Junjiang Wu, Pengfei Xu, Shuzhen Zhang   +19 more
wiley   +1 more source

Modeling Fabry nephropathy: insights from experimental systems towards precision nephrology. [PDF]

Dis Model Mech
Elsaid H, Furriol J, Eikrem Ø, Tøndel C, Svarstad E.   +4 more
europepmc   +1 more source

Magnesium Attenuates Renal Senescence and Fibrosis With Reduced DNA Damage Response and H3K4me3 Enrichment at the p16INK4a Promoter

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Magnesium (Mg2+) attenuates renal injury in ischemia–reperfusion and radiation‐induced kidney injury models in association with reduced DNA damage response markers, cellular senescence, inflammation, and fibrosis. Mg2+ treatment is associated with reduced H3K4me3 enrichment at the p16INK4a promoter, attenuation of senescence‐associated pathways, and ...
Makoto Matsubara, Kensuke Sasaki, Shigehiro Doi, Takeshi Ike, Maria Yoshida, Akira Takahashi, Yosuke Osaki, Naoki Ishiuchi, Aiko Okubo, Yujiro Maeoka, Takuto Chiba, Ayumu Nakashima, Takao Masaki   +12 more
wiley   +1 more source

Clinical and Biochemical Improvement After Switching From Agalsidase Alfa to Beta in a Boy With Classic Fabry Disease: A Case Report. [PDF]

Clin Case Rep
Koga N, Yodogawa H, Sawada T, Mushimoto Y, Nagamitsu S, Nakamura K, Hirose S, Inoue T.   +7 more
europepmc   +1 more source