DPP‐4 Inhibitors associated withheart failure events in patients with type‐2 diabetes. This study found statistically insignificant summary effect for all DPP‐4 inhibitors combined but found asignificant association of saxagliptin with heart failure events (RR = 1.24, 95% CI 1.05–1.47). Results are to be interpreted with caution.
Shishir Nepal, Shiva Prasad Nepal
wiley +1 more source
Enzyme replacement therapy during pregnancy and breastfeeding in late-onset Pompe disease. [PDF]
Bachmann M +7 more
europepmc +1 more source
Kiwifruit seed polyphenols (KSP) alleviate high‐fat diet‐induced obesity and metabolic dysfunction in mice by reducing body weight gain, adiposity, hepatic steatosis, and insulin resistance. KSP also suppresses inflammation, improves lipid metabolism, and reshapes gut microbiota composition, restoring short‐chain fatty acid production, thereby ...
Qingqing Liu +7 more
wiley +1 more source
Safety evaluation of the food enzyme glucan 1,4-α-glucosidase from the genetically modified <i>Trichoderma reesei</i> strain DP-Nzh109. [PDF]
EFSA Panel on Food Enzymes (FEZ) +16 more
europepmc +1 more source
Intelligent design of artificial biocatalyst for biomedical diseases
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang +3 more
wiley +1 more source
Synthesis and Application of a Suite of 2,5-Aryl Tetrazole Photoaffinity-Based Probes for Profiling Microbial Carbohydrate and Mucin Metabolism in Gut Microbiota. [PDF]
Russo J +4 more
europepmc +1 more source
A Perspective of Soy Isoflavones on Analytical, Biological, and Chemical Attributes
ABSTRACT This review covers key aspects of soybean (Glycine max), with a particular focus on its isoflavone content and biological properties. Soybeans maintain their position as both a nutraceutical and a pharmaceutical crop, with a broad range of dietary items used worldwide, including soy milk, fermented soy products, and various dietary supplements.
Sristy Suman +4 more
wiley +1 more source
Glycosidase Isoforms in Honey and the Honey Bee (<i>Apis mellifera</i> L.): Differentiating Bee- and Yeast-Derived Enzymes and Implications for Honey Authentication. [PDF]
Pavlović R +6 more
europepmc +1 more source
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid +4 more
wiley +1 more source
Porcine serum maltase-glucoamylase: structure, kinetics, and inhibition. [PDF]
Watanabe K +7 more
europepmc +1 more source

