Results 1 to 10 of about 5,356 (147)

Emerging gut microbial glycoside hydrolase inhibitors. [PDF]

RSC Chem Biol
Glycoside hydrolase inhibitors are emerging as valuable tools to study gut microbial enzymes that modulate host physiology and disease by degrading dietary, drug-related, and host-derived glycans.
Kowalewski ME, Redinbo MR.
europepmc   +3 more sources

α-Glucosidase-driven metabolism as a potential therapeutic vulnerability in Candida albicans [PDF]

Frontiers in Microbiology
Candida albicans remains a leading etiological agent of both mucosal and invasive fungal infections. The increasing prevalence of antifungal resistance and limited therapeutic options pose a significant clinical challenge and highlight the need for novel
Joyati Mitra, Anusree Sajeevan, Swathi Sujith, Sasvin Paramasivam, Karthi Shanmugam, Karthi Shanmugam, Adline Princy Solomon   +6 more
doaj   +2 more sources

Characterization of Two Wheat-Derived Glycoside Hydrolase Family-10 Xylanases Resistant to Xylanase Inhibitors

Journal of Food Quality, 2022
Xylanase inhibitors inhibit the activities of microbial xylanases and seriously compromise the efficacy of microbial xylanases added to modify cereals.
Fangfang Liang, Yi Mo, Suleman Shah, Ying Xie, Arshad Mehmood, Hesheng Jiang, Yafen Guo   +6 more
doaj   +2 more sources

Emergence of a subfamily of xylanase inhibitors within glycoside hydrolase family 18 [PDF]

FEBS Journal, 2005
The xylanase inhibitor protein I (XIP‐I), recently identified in wheat, inhibits xylanases belonging to glycoside hydrolase families 10 (GH10) and 11 (GH11). Sequence and structural similarities indicate that XIP‐I is related to chitinases of family GH18, despite its lack of enzymatic activity.
Nathalie Juge, Richard Hughes, Bernard Henrissat   +2 more
exaly   +3 more sources

Blue light regulates conidia production in Shiraia bambusicola via calcium/calmodulin signaling [PDF]

AMB Express
Shiraia bambusicola is a valuable medicinal fungus parasitic on bamboo, and extracting its active substances represents a sustainable resource utilization strategy.
Wen Du, Chunlong Sun, Shuai Shang, Wang Li, Wenwen Huang, Ran Wang, Jian Li, Guolan Liu, Hongguo Wang, Chenzhao Wang, Zhiwei Su, Qian Yang   +11 more
doaj   +2 more sources

Interactions between Glycoside Hydrolase Family 94 Cellobiose Phosphorylase and Glucosidase Inhibitors

Journal of Applied Glycoscience (1999), 2011
Azasugars are known as potent inhibitors of glycoside hydrolases. In this study, we examined the inhibition of Cellvibrio gilvus cellobiose phosphorylase (CBP) by four azasugars (isofagomine, 1-deoxynojirimycin, castanospermine and calystegine B2) and a non-azasugar (glucono-1,5-lactone).
Motomitsu Kitaoka, Shinya Fushinobu, Takayoshi Wakagi   +2 more
exaly   +3 more sources

Structural insights into the inhibition mechanism of glucosidase inhibitors toward kojibiose hydrolase belonging to glycoside hydrolase family 65

Bioscience, Biotechnology and Biochemistry
Abstract Glycoside hydrolase family 65 (GH65) includes glycoside hydrolases active on various α-glucosides. We previously demonstrated that the GH65 enzyme from Flavobacterium johnsoniae (FjGH65A) is a kojibiose hydrolase and determined its 3-dimensional structure. In this study, the effects of glucosidase inhibitors on FjGH65A and their
Takatsugu Miyazaki, Shuntaro Nakamura, Miyazaki Takatsugu   +2 more
exaly   +3 more sources

Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases [PDF]

Frontiers in Molecular Biosciences, 2021
Kasugamycin, a well-known aminoglycoside antibiotic, has been used widely in agriculture and medicine to combat microbial pathogens by binding the ribosome to inhibit translation. Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from three different organisms (bacterium, insect and human).
Huitang Qi, Xi Jiang, Yi Ding, Tian Liu, Qing Yang, Qing Yang, Qing Yang   +6 more
openaire   +3 more sources

Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases

JACS Au, 2023
Allylic cyclitols were investigated as covalent inhibitors of glycoside hydrolases by chemical, enzymatic, proteomic, and computational methods. This approach was inspired by the C$_{7}$ cyclitol natural product streptol glucoside, which features a potential carbohydrate leaving group in the 4-position (carbohydrate numbering). To test this hypothesis,
Grayfer, Tatyana D, Yamani, Khalil, Jung, Erik, Chesnokov, Gleb A, Ferrara, Isabella, Hsiao, Chien-Chi, Georgiou, Antri, Michel, Jeremy, Bailly, Aurélien, Sieber, Simon, Eberl, Leo, Gademann, Karl   +11 more
openaire   +2 more sources

Characterization of Glycoside Hydrolase Families 13 and 31 Reveals Expansion and Diversification of α-Amylase Genes in the Phlebotomine Lutzomyia longipalpis and Modulation of Sandfly Glycosidase Activities by Leishmania Infection

Frontiers in Physiology, 2021
Sugar-rich food sources are essential for sandflies to meet their energy demands, achieving more prolonged survival. The digestion of carbohydrates from food is mainly realized by glycoside hydrolases (GH). To identify genes coding for α-glycosidases and
Samara Graciane da Costa-Latgé, Paul Bates, Rod Dillon, Rod Dillon, Fernando Ariel Genta, Fernando Ariel Genta   +5 more
doaj   +1 more source