Results 21 to 30 of about 5,356 (147)

Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design

Chemical Science, 2020
Positive charge stabilized on remote C5-allylic center with catalysis occurring via a loose S N 2 transition state.
Weiwu Ren, Marco Farren-Dai, Natalia Sannikova, Katarzyna Świderek, Yang Wang, Oluwafemi Akintola, Robert Britton, Vicent Moliner, Andrew J. Bennet   +8 more
openaire   +4 more sources

Fully Deacetylated Chitooligosaccharides Act as Efficient Glycoside Hydrolase Family 18 Chitinase Inhibitors [PDF]

Journal of Biological Chemistry, 2014
Small molecule inhibitors against chitinases have potential applications as pesticides, fungicides, and antiasthmatics. Here, we report that a series of fully deacetylated chitooligosaccharides (GlcN)2-7 can act as inhibitors against the insect chitinase OfChtI, the human chitinase HsCht, and the bacterial chitinases SmChiA and SmChiB with IC50 values ...
Lei, Chen, Yong, Zhou, Mingbo, Qu, Yong, Zhao, Qing, Yang   +4 more
openaire   +2 more sources

Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S [PDF]

Organic & Biomolecular Chemistry, 2017
We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylase Streptomyces coelicolor ( Sco ) GlgEI-V279S which plays a role in α-glucan biosynthesis.
Sri Kumar, Veleti, Cecile, Petit, Jared J, Lindenberger, Donald R, Ronning, Steven J, Sucheck   +4 more
openaire   +2 more sources

A new chitinase-like xylanase inhibitor protein (XIP) from coffee (Coffea arabica) affects Soybean Asian rust (Phakopsora pachyrhizi) spore germination

BMC Biotechnology, 2011
Background Asian rust (Phakopsora pachyrhizi) is a common disease in Brazilian soybean fields and it is difficult to control. To identify a biochemical candidate with potential to combat this disease, a new chitinase-like xylanase inhibitor protein (XIP)
Mehta Angela, Filho Edivaldo XF, Fitches Elaine, Price Daniel, Oliveira-Neto Osmundo B, Silva Marilia S, Moreira Leonora RS, Seixas Claudine DS, Godoy Claudia V, Santana Celso G, Vasconcelos Erico AR, Gatehouse John A, Grossi-De-Sa Maria F   +12 more
doaj   +1 more source

Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases

Molecules
Glycoside hydrolases have been implicated in a wide range of human conditions including lysosomal storage diseases. Consequently, many researchers have directed their efforts towards identifying new classes of glycoside hydrolase inhibitors, both ...
Oluwafemi Akintola, Sandeep Bhosale, Andrew J. Bennet   +2 more
doaj   +1 more source

Small Molecule Inhibitors of a Glycoside Hydrolase Attenuate Inducible AmpC-mediated β-Lactam Resistance [PDF]

Journal of Biological Chemistry, 2007
The increasing spread of plasmid-borne ampC-ampR operons is of considerable medical importance, since the AmpC beta-lactamases they encode confer high level resistance to many third generation cephalosporins. Induction of AmpC beta-lactamase from endogenous or plasmid-borne ampC-ampR operons is mediated by a catabolic inducer molecule, 1,6-anhydro-N ...
Keith A, Stubbs, Misty, Balcewich, Brian L, Mark, David J, Vocadlo   +3 more
openaire   +2 more sources

Variation in the Number of Genes in the Secretomes of Isolates of Ilyonectria robusta and Ilyonectria mors-panacis Pathogenic to American Ginseng (Panax quinquefolius)

Horticulturae
For 12 isolates of Ilyonectria mors-panacis and 4 isolates of Ilyonectria robusta, the number of genes in the secretome showed a negative correlation with growth rates in culture, especially for small secreted non-cysteine-rich and cysteine-rich proteins,
Paul H. Goodwin, Moez Valliani, Tom Hsiang   +2 more
doaj   +1 more source

Genome-wide transcriptional analysis of super-embryogenic Medicago truncatula explant cultures

BMC Plant Biology, 2008
Background The Medicago truncatula (M. truncatula) line 2HA has a 500-fold greater capacity to regenerate plants in culture by somatic embryogenesis than its wild type progenitor Jemalong.
Rolfe Barry G, Goffard Nicolas, Nizamidin Mahira, Imin Nijat   +3 more
doaj   +1 more source

The effect of carbohydrate binding modules and linkers on inhibitor binding to family 18 glycoside hydrolases [PDF]

The Journal of Chemical Thermodynamics, 2018
Abstract Enzyme catalyzed hydrolysis of glycosidic bonds is undertaken by glycoside hydrolases (GHs) in nature. In addition to a catalytic domain (CD), GHs often have carbohydrate-binding modules (CBMs) attached to the CD through a linker. Allosamidin binding to full-length GH18 Serratia marcescens ChiB and the catalytic domain only yield equal ...
Eide, Kristine Bistrup, Sørlie, Morten
openaire   +2 more sources

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source