Results 31 to 40 of about 10,058 (190)

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

Journal of Lipid Research, 2014
Glycosphingolipid (GSL) storage diseases have been the focus of efforts to develop small molecule therapeutics from design, experimental proof of concept studies, and clinical trials.
James A. Shayman, Scott D. Larsen
doaj   +1 more source

O-GlcNAcase:promiscuous hexosaminidase or key regulator of O-GlcNAc signalling? [PDF]

, 2014
O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
Banerjee, Butkinaree, Cantarel, Cecioni, Cetinba, Comtesse, Copeland, Dennis, Dong, Dorfmueller, Dorfmueller, Drougat, Forsythe, Francisco, Gao, Gong, Graham, Guinez, Hanover, Hart, Hayakawa, He, He, Heckel, Hilgers, Housley, Howerton, Hu, Itkonen, Keembiyehetty, Knapp, Laczy, Lefebvre, Lepage, Libina, Liu, Macauley, Macauley, Macauley, Macauley, Macauley, Mahuran, Martin, Minami, Müller, Nagel, Olszewski, Ostrowski, Pathak, Penton, Radermacher, Rahman, Rao, Rao, Robinson, Ruan, Ruan, Schimpl, Schimpl, Schultz, Sekine, Shen, Slawson, Speakman, Stryke, Swallow, Tews, Toleman, Toleman, Torres, Wang, Wang, Webster, Wells, Whisenhunt, Whitworth, Yang, Yu, Yuzwa, Yuzwa, Zachara, Zachara, Zhu   +82 more
core   +3 more sources

Microbial xylanases and their inhibition by specific proteins in cereals

Kvasný průmysl, 2019
Arabinoxylans (AXs) belong to the components of plant cells which are mainly degraded by microbial xylanases during colonization of grain by phytopathogens.
Daniela Chmelová, Dominika Škulcová, Miroslav Ondrejovic   +2 more
doaj   +1 more source

Glycoside hydrolase activities of thermophilic bacterial consortia adapted to switchgrass [PDF]

, 2011
Industrial-scale biofuel production requires robust enzymatic cocktails to produce fermentable sugars from lignocellulosic biomass. Thermophilic bacterial consortia are a potential source of cellulases and hemicellulases adapted to harsher reaction ...
Gladden, John M., Allgaier, Martin, Miller, Christopher S., Hazen, Terry C., VanderGheynst, Jean S., Hugenholtz, Philip, Simmons, Blake A., Singer, Steven W.   +7 more
core   +3 more sources

Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design

Chemical Science, 2020
Positive charge stabilized on remote C5-allylic center with catalysis occurringviaa loose SN2 transition state.
Weiwu Ren, Marco Farren-Dai, Natalia Sannikova, Katarzyna Świderek, Yang Wang, Oluwafemi Akintola, Robert Britton, Vicent Moliner, Andrew J. Bennet   +8 more
openaire   +4 more sources

Substrate-Assisted Catalysis Unifies Two Families of Chitinolytic Enzymes [PDF]

, 1997
Hen egg-white lysozyme has long been the paradigm for enzymatic glycosyl hydrolysis with retention of configuration, with a protonated carboxylic acid and a deprotonated carboxylate participating in general acid-base catalysis.
Blake C. C. F., C−, Davies G. J., Ford L. O., Henrissat B., Iseli B., Johnson L. N., Jones T. A., Kirby A., Knapp S., Kobayashi S., Koshland D. E., Perrakis A., Phillips D. C., Piszkiewicz D., Rao V. H., Rozeboom H. J., Sinnot M. L., Strynadka N. C. J., Sulzenbacher G., Terwisscha van Scheltinga A. C., Terwisscha van Scheltinga A. C., Terwisscha van Scheltinga A. C., Tews I., Thunnissen A. M. W. H., Tronrud D. E., van Roey P., Vårum K. M., Weaver L. H.   +28 more
core   +3 more sources

Bioinformatic characterisation of genes encoding cell wall degrading enzymes in the Phytophthora parasitica genome [PDF]

, 2016
BACKGROUND A critical aspect of plant infection by the majority of pathogens is penetration of the plant cell wall. This process requires the production and secretion of a broad spectrum of pathogen enzymes that target and degrade the many complex ...
Blackman, Leila M., Cullerne, Darren, Hardham, Adrienne R.   +2 more
core   +2 more sources

Amylases and Their Importance during Glycan Degradation: Genome Sequence Release of Salmonella Amylase Knockout Strains. [PDF]

, 2017
Amylases catalyze the cleavage of α-d-1,4 and α-d-1,6-glycosidic bonds in starch and related carbohydrates. Amylases are widely distributed in nature and are important in carbohydrate metabolism.
Arabyan, Narine, Huang, Bihua C, Weimer, Bart C   +2 more
core   +1 more source

Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S [PDF]

Organic & Biomolecular Chemistry, 2017
We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylaseStreptomyces coelicolor(Sco) GlgEI-V279S which plays a role in α-glucan biosynthesis.
Sri Kumar, Veleti, Cecile, Petit, Jared J, Lindenberger, Donald R, Ronning, Steven J, Sucheck   +4 more
openaire   +2 more sources

A new chitinase-like xylanase inhibitor protein (XIP) from coffee (Coffea arabica) affects Soybean Asian rust (Phakopsora pachyrhizi) spore germination

BMC Biotechnology, 2011
Background Asian rust (Phakopsora pachyrhizi) is a common disease in Brazilian soybean fields and it is difficult to control. To identify a biochemical candidate with potential to combat this disease, a new chitinase-like xylanase inhibitor protein (XIP)
Mehta Angela, Filho Edivaldo XF, Fitches Elaine, Price Daniel, Oliveira-Neto Osmundo B, Silva Marilia S, Moreira Leonora RS, Seixas Claudine DS, Godoy Claudia V, Santana Celso G, Vasconcelos Erico AR, Gatehouse John A, Grossi-De-Sa Maria F   +12 more
doaj   +1 more source