Results 51 to 60 of about 10,058 (190)

Biochemical Characterization of Diamide Inhibitors with N-acetylglucosaminidases LytG from Bacillus subtilis [PDF]

, 2016
In recent years the frequency of antibiotic resistance has been on the rise creating a need for antibiotic development with specific and lethal targets.
Phelan, Drew
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

His374 of wheat endoxylanase inhibitor TAXI‐I stabilizes complex formation with glycoside hydrolase family 11 endoxylanases [PDF]

The FEBS Journal, 2005
Wheat endoxylanase inhibitor TAXI‐I inhibits microbial glycoside hydrolase family 11 endoxylanases. Crystallographic data of an Aspergillus niger endoxylanase‐TAXI‐I complex showed His374 of TAXI‐I to be a key residue in endoxylanase inhibition [Sansen S, De Ranter CJ, Gebruers K, Brijs K, Courtin CM, Delcour JA & Rabijns A (2004) J Biol Chem 279 ...
Katleen, Fierens, Ann, Gils, Stefaan, Sansen, Kristof, Brijs, Christophe M, Courtin, Paul J, Declerck, Camiel J, De Ranter, Kurt, Gebruers, Anja, Rabijns, Johan, Robben, Steven, Campenhout, Guido, Volckaert, Jan A, Delcour   +12 more
openaire   +2 more sources

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Characterization of thermophilic β-Glucosidase of rhizospheric bacterial strain (LSKB15) isolated from Cholistan Desert, Pakistan [PDF]

, 2018
Fifty thermophilic bacterial strains isolated from rhizospheric soil of Cholistan desert, Pakistan, and designated as LSKB01-LSKB50 were screened for β-glucosidase gene (bgl) belonging to glycoside hydrolase family 1 (GH 1) using PCR technique ...
Ahmed, Amer, Batool, Kashfa, Bibi, Aasia, Rafi, Sarwat, ul Hassan Nasim, Faiz   +4 more
core  

Structure and activity of the Streptococcus pyogenes family GH1 6-phospho β-glycosidase, Spy1599 [PDF]

, 2013
The group A streptococcus Streptococcus pyogenes is the causative agent of a wide spectrum of invasive infections, including necrotizing fasciitis, scarlet fever and toxic shock syndrome.
Aguilar-Moncayo, Ajdić, Cantarel, Collin, Conejo, Cowtan, Cowtan, Edward J. Taylor, Emsley, Evans, Fujita, Gideon J. Davies, Gregg, Harry Brumer, Henrissat, Henrissat, Hondorp, Jens M. Eklof, Jerome Dabin, Jin, Johan P. Turkenburg, Judith Stepper, Kabsch, Kietzman, Kori, Leslie, McNicholas, Murshudov, Padilla, Pancholi, Prachumporn Kongsaeree, Preeyanuch Thongpoo, Ryan, Ryan, Seshadri, Shelburne, Shelburne, Shelburne, Sheldon, Suck, Suits, Vagin, Wiesmann, Wiesmann, Winn, Winter, Wright, Zechel   +47 more
core   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis [PDF]

, 2008
Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for ...
Bunzo Mikami, Kousaku Murata, Takafumi Itoh, Wataru Hashimoto, Yukie Maruyama   +4 more
core   +2 more sources

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

GH97 is a new family of glycoside hydrolases, which is related to the α-galactosidase superfamily [PDF]

, 2005
Background As a rule, about 1% of genes in a given genome encode glycoside hydrolases and their homologues. On the basis of sequence similarity they have been grouped into more than ninety GH families during the last 15 years.
Naumoff Daniil G
core   +1 more source