Results 51 to 60 of about 5,356 (147)

Mechanistic studies of glycoside hydrolase substrates and inhibitors

, 2021
Glycoside hydrolases (GHs) are the enzymes that catalyze the cleavage of glycosidic bonds, which link carbohydrate units to other biomolecules. The work in this thesis comprises mechanistic studies of various GHs with experimental and computational methods.
openaire   +1 more source

Biocompatible Sulfobetaine Polymer‐Artemisinin Conjugates Inducing Ferroptosis in Cancer Cells: Synthesis by Mechanochemical Solid‐State Polymerization and Characterization

Macromolecular Rapid Communications, Volume 47, Issue 15, 4 August 2026.
The amphiphilic copolymer incorporating a hydrophobic chain conjugated with artesunate into a biocompatible sulfobetaine polymer is synthesized by solid‐state copolymerization of sulfobetaine methacrylate and methacrylamide derivative conjugating artesunate.
Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Ryosuke Nagai, Ayaka Koike, Madoka Ikawa, Toru Yoshimoto, Satoshi Yamada, Masayuki Kuzuya, Shin‐ichi Kondo   +9 more
wiley   +1 more source

Experimental estimation of copper‐site geometry reproducibility in biologically relevant redox and saccharide‐bound states of a model lytic polysaccharide monooxygenase

Acta Crystallographica Section D, Volume 82, Issue 8, Page 886-899, August 2026.
Small but measurable changes in the coordination geometry of a lytic polysaccharide monooxygenase copper active site are revealed by X‐ray crystallography, providing structural insight into their catalytic flexibility.Lytic polysaccharide monooxygenases (LPMOs) are copper‐dependent enzymes classified into the auxiliary activity (AA) families of the ...
Zhiyu Huang, Qiuyi Wei, Jie Nan, Morten H. H. Nørholm, Zimeng Liu, Cristina Hernández-Rollán, Katja S. Johansen, Leila Lo Leggio   +7 more
wiley   +1 more source

Degradable versus inert microplastics: Effects on soil organic carbon persistence via microbial drivers in an agroecosystem

Functional Ecology, Volume 40, Issue 8, Page 2628-2641, August 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Microplastics (MPs) are widespread in terrestrial ecosystems, raising global concerns that they may disrupt soil organic carbon (SOC) cycling and undermine agroecosystem contributions to climate mitigation.
Meng‐Ying Li, Wei Wang, Yue Ma, Jia‐Yao Yang, Shu‐Tong Liu, Xiao‐Bin Xiong, Tingting Zhao, Yuanze Sun, Saddam Saqib, Muhammd Ashraf, Matthias C. Rillig, You‐Cai Xiong   +11 more
wiley   +1 more source

Ultrafiltration of Milk: Effect on Lactoferrin, Lysozyme, and Lactoperoxidase Activity During Cheddar Cheese Ripening

Journal of Food Process Engineering, Volume 49, Issue 8, August 2026.
The retention of lactoferrin lactoperoxidase, and lysozyme in milk concentrated by ultrafiltration (UF) before cheesemaking and on cheese properties was studied. Cheese made with concentrated milk retained 17% more LF than the control. No effect on cheese properties was observed. UF could be an additional tool to enhance cheese bioactivity.
Marie‐Claude Gentès, Francis Quesnel, Rachel Langlois‐Deshaies, Annie Caron   +3 more
wiley   +1 more source

Orchid genome evolution and trait innovation

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2577-2607, August 2026.
Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng, Cheng‐Yuan Zhou, Linying Wang, Jie Gao, Weilun Yin, Dong‐Hui Peng, Siren Lan, Feng‐Xi Yang, Zhong‐Jian Liu   +8 more
wiley   +1 more source

Synthesis of conformationally constrained inhibitors for glycoside hydrolases

, 2019
Glycoside hydrolase (GH) enzymes are clinically relevant biological targets for drug development. Disfunction of the two lysosomal GHs β-glucocerebrosidase and α-galactosidase can lead to Gaucher and Fabry’s disease, respectively. With knowledge of their mechanisms of action it is possible to create compounds that would effectively modulate their ...
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Designing selective inhibitors to target NagZ a family 3 glycoside hydrolase [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2008
M.D. Balcewich, T. James, K. Stubbs, D. Vocadlo, B. Mark   +4 more
openaire   +1 more source

BIOCHEMICAL FUNCTIONAL CHARACTERIZATION AND MOLECULAR BIOLOGY OF PLANT INHIBITOR PROTEINS ACTING AGAINST GLYCOSIDE HYDROLASE

, 2017
Plant cell walls are composed mostly of polysaccharides and it consist of three layers (the primary cell wall, the secondary cell wall and the middle lamella) that are made up of different percentage of cellulose, pectins and hemicelluloses. These latter are composed of a linear backbone made up of (1,4)-?-D-glycans with an equatorial configuration ...
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Structural analysis of a newly identified class of plant protective microbial glycoside hydrolase inhibitors [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2004
S. Sansen, C. J. De Ranter, K. Gebruers, K. Brijs, C. M. Courtin, J. A. Delcour, A. Rabijns   +6 more
openaire   +1 more source