Results 11 to 20 of about 5,356 (159)
Emerging gut microbial glycoside hydrolase inhibitors. [PDF]
RSC Chem BiolGlycoside hydrolase inhibitors are emerging as valuable tools to study gut microbial enzymes that modulate host physiology and disease by degrading dietary, drug-related, and host-derived glycans.
Kowalewski ME, Redinbo MR.
europepmc +3 more sources
Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases [PDF]
Frontiers in Molecular Biosciences, 2021 Kasugamycin, a well-known aminoglycoside antibiotic, has been used widely in agriculture and medicine to combat microbial pathogens by binding the ribosome to inhibit translation. Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from three different organisms (bacterium, insect and human).
Huitang Qi +6 more
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Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases
JACS Au, 2023 Allylic cyclitols were investigated as covalent inhibitors of glycoside hydrolases by chemical, enzymatic, proteomic, and computational methods. This approach was inspired by the C$_{7}$ cyclitol natural product streptol glucoside, which features a potential carbohydrate leaving group in the 4-position (carbohydrate numbering). To test this hypothesis,
Grayfer, Tatyana D +11 more
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BMC Biology, 2022 Background β-1,4-endoglucanase (EG) is one of the three types of cellulases used in cellulose saccharification during lignocellulosic biofuel/biomaterial production. GsCelA is an EG secreted by the thermophilic bacterium Geobacillus sp.
Mei-Huey Wu +4 more
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My Times with Professor Igor Kregar and some Hydrolytic Enzymes
Acta Chimica Slovenica, 2019 The late Professor Igor Kregar and this author had several overlapping biochemical research interests. One focus was the glycoside hydrolase, lysozyme, and the other was proteolytic enzymes and their inhibitors, in particular those present in tissues ...
Karl J. Kramer
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Journal of Lipid Research, 2014 Glycosphingolipid (GSL) storage diseases have been the focus of efforts to develop small molecule therapeutics from design, experimental proof of concept studies, and clinical trials.
James A. Shayman, Scott D. Larsen
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Microbial xylanases and their inhibition by specific proteins in cereals
Kvasný průmysl, 2019 Arabinoxylans (AXs) belong to the components of plant cells which are mainly degraded by microbial xylanases during colonization of grain by phytopathogens.
Daniela Chmelová +2 more
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Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design
Chemical Science, 2020 Positive charge stabilized on remote C5-allylic center with catalysis occurringviaa loose SN2 transition state.
Weiwu Ren +8 more
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Fully Deacetylated Chitooligosaccharides Act as Efficient Glycoside Hydrolase Family 18 Chitinase Inhibitors [PDF]
Journal of Biological Chemistry, 2014 Small molecule inhibitors against chitinases have potential applications as pesticides, fungicides, and antiasthmatics. Here, we report that a series of fully deacetylated chitooligosaccharides (GlcN)2-7 can act as inhibitors against the insect chitinase OfChtI, the human chitinase HsCht, and the bacterial chitinases SmChiA and SmChiB with IC50 values ...
Lei, Chen +4 more
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BMC Biotechnology, 2011 Background Asian rust (Phakopsora pachyrhizi) is a common disease in Brazilian soybean fields and it is difficult to control. To identify a biochemical candidate with potential to combat this disease, a new chitinase-like xylanase inhibitor protein (XIP)
Mehta Angela +12 more
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