Results 11 to 20 of about 10,058 (190)

Emerging gut microbial glycoside hydrolase inhibitors. [PDF]

RSC Chem Biol
Glycoside hydrolase inhibitors are emerging as valuable tools to study gut microbial enzymes that modulate host physiology and disease by degrading dietary, drug-related, and host-derived glycans.
Kowalewski ME, Redinbo MR.
europepmc   +2 more sources

Characterization of Two Wheat-Derived Glycoside Hydrolase Family-10 Xylanases Resistant to Xylanase Inhibitors

Journal of Food Quality, 2022
Xylanase inhibitors inhibit the activities of microbial xylanases and seriously compromise the efficacy of microbial xylanases added to modify cereals.
Fangfang Liang, Yi Mo, Suleman Shah, Ying Xie, Arshad Mehmood, Hesheng Jiang, Yafen Guo   +6 more
doaj   +2 more sources

Emergence of a subfamily of xylanase inhibitors within glycoside hydrolase family 18 [PDF]

The FEBS Journal, 2005
The xylanase inhibitor protein I (XIP‐I), recently identified in wheat, inhibits xylanases belonging to glycoside hydrolase families 10 (GH10) and 11 (GH11). Sequence and structural similarities indicate that XIP‐I is related to chitinases of family GH18, despite its lack of enzymatic activity.
Anne, Durand, Richard, Hughes, Alain, Roussel, Ruth, Flatman, Bernard, Henrissat, Nathalie, Juge   +5 more
openaire   +4 more sources

Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl carbasugars [PDF]

Angewandte Chemie - International Edition, 2016
This work was supported by an NSERC Discovery Grant (AJB: #121348-2012), a Wellcome Trust Career Development Fellowship (TMG: grant 095828), a Wellcome Trust Institutional Strategic Support award (TMG and RJP), a MSFHR Career Investigator Award (RB), a ...
Bergeron-Brlek, Bergeron-Brlek, Bergeron-Brlek, Blakemore, Chakladar, Doyle, Friedrich, Grondal, Grondal, Lowry, Merceron, Michal, Schramm, Schramm, Schramm, Schwarz, Sinnott, Sinnott, Sinnott, Vocadlo, Vocadlo, Withers, Wolfenden, Wolfenden   +23 more
core   +3 more sources

Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases [PDF]

Molecules
Glycoside hydrolases have been implicated in a wide range of human conditions including lysosomal storage diseases. Consequently, many researchers have directed their efforts towards identifying new classes of glycoside hydrolase inhibitors, both ...
Oluwafemi Akintola, Sandeep Bhosale, Andrew J. Bennet   +2 more
doaj   +2 more sources

Blue light regulates conidia production in Shiraia bambusicola via calcium/calmodulin signaling [PDF]

AMB Express
Shiraia bambusicola is a valuable medicinal fungus parasitic on bamboo, and extracting its active substances represents a sustainable resource utilization strategy.
Wen Du, Chunlong Sun, Shuai Shang, Wang Li, Wenwen Huang, Ran Wang, Jian Li, Guolan Liu, Hongguo Wang, Chenzhao Wang, Zhiwei Su, Qian Yang   +11 more
doaj   +2 more sources

High resolution crystal structure of the Endo-N-acetyl-beta-D-glucosaminidase responsible for the deglycosylation of hypocrea jecorina cellulases [PDF]

, 2012
Endo-N-acetyl-beta-D-glucosaminidases (ENGases) hydrolyze the glycosidic linkage between the two N-acetylglucosamine units that make up the chitobiose core of N-glycans. The endo-N-acetyl-beta-D-glucosaminidases classified into glycoside hydrolase family
Anita Van Landschoot, Bart Devreese, Ingeborg Stals, Mats Sandgren, Michael Ward, Renwick Dobson, Saeid Karkehabadi, Steve Kim   +7 more
core   +18 more sources

Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases

JACS Au, 2023
Allylic cyclitols were investigated as covalent inhibitors of glycoside hydrolases by chemical, enzymatic, proteomic, and computational methods. This approach was inspired by the C7 cyclitol natural product streptol glucoside, which features a potential carbohydrate leaving group in the 4-position (carbohydrate numbering).
Grayfer, Tatyana D, Yamani, Khalil, Jung, Erik, Chesnokov, Gleb A, Ferrara, Isabella, Hsiao, Chien-Chi, Georgiou, Antri, Michel, Jeremy, Bailly, Aurélien, Sieber, Simon, Eberl, Leo, Gademann, Karl   +11 more
openaire   +2 more sources

Characterization of Glycoside Hydrolase Families 13 and 31 Reveals Expansion and Diversification of α-Amylase Genes in the Phlebotomine Lutzomyia longipalpis and Modulation of Sandfly Glycosidase Activities by Leishmania Infection

Frontiers in Physiology, 2021
Sugar-rich food sources are essential for sandflies to meet their energy demands, achieving more prolonged survival. The digestion of carbohydrates from food is mainly realized by glycoside hydrolases (GH). To identify genes coding for α-glycosidases and
Samara Graciane da Costa-Latgé, Paul Bates, Rod Dillon, Rod Dillon, Fernando Ariel Genta, Fernando Ariel Genta   +5 more
doaj   +1 more source

Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases [PDF]

Frontiers in Molecular Biosciences, 2021
Kasugamycin, a well-known aminoglycoside antibiotic, has been used widely in agriculture and medicine to combat microbial pathogens by binding the ribosome to inhibit translation. Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from three different organisms (bacterium, insect and human).
Huitang Qi, Xi Jiang, Yi Ding, Tian Liu, Qing Yang, Qing Yang, Qing Yang   +6 more
openaire   +3 more sources