Results 61 to 70 of about 6,039 (288)

Intensive versus conventional glycaemic control for treating diabetic foot ulcers [PDF]

, 2016
Background  The estimated likelihood of lower limb amputation is 10 to 30 times higher amongst people with diabetes compared to those without diabetes. Of all non-traumatic amputations in people with diabetes, 85% are preceded by a foot ulcer.
Buttner, Petra, Cunningham, Margaret, Fernando, Malindu, Golledge, Jonathan, Lazzarini, Peter, Sangla, Kunwarjit, Seneviratne, Ridmee M, Tan, Yong Mong   +7 more
core   +2 more sources

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

Epilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin, Hui‐Min Huang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Clinical efficacy of Myozyme on one ventilator dependent patient with late-onset glycogen storage disease typeⅡ

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Objective To evaluate the effect of Myozyme on one ventilator dependent patient with late-onset glycogen storage disease typeⅡ (GSDⅡ).  Methods Myozyme infusion was administered based on manufacturer's recommendations at 20 mg/kg every 2 to 4 weeks ...
Juan YANG, Wei-xun FENG, Ji-qing CAO, Yan-yun WANG, Ya-qin LI, Shi-biao HUANG, Yan-jun LUO, Zhuo-lin LIU, Yi-ming SUN, Zhen-hua LIU, Cheng ZHANG   +10 more
doaj  

.ALPHA.-Glucosidase Inhibitors from Millettia conraui

Chemical and Pharmaceutical Bulletin, 2007
A new geranylated isoflavone, 7-O-geranyl-6-methoxypseudobaptigenin (1) was isolated from the stem barks of Millettia conraui, along with known compounds 5-methoxydurmillone (2), conrauinone A (3), beta-amyrine (4), sitosterol (5), 3-O-beta-D-glucopyranosyl sitosterol (6) and n-docosanol (7).
Alembert, Tiabou Tchinda, Shamsun, Nahar Khan, Victorine, Fuendjiep, François, Ngandeu, Annie, Ngono Ngane, Muhammad Iqbal, Choudhary   +5 more
openaire   +3 more sources

Recent Progress on Enzyme Immobilization: Materials, Strategies, and Applications

Food Bioengineering, EarlyView.
Enzyme immobilization technology has undergone substantial evolution driven by advances in materials science. This review systematically examines the recent advances in enzyme immobilization since 2024, with a focused analysis of five major categories of enzyme carriers including covalent organic framework, metal‐organic frameworks, polymers, carbon ...
Shuran Wang, Ruoke Li, Yixuan Xie, Hanya Zhang, Xiaoyu Huang, Siwei Chen, Weixin Xu, Yueling Liu   +7 more
wiley   +1 more source

Hyperthermophilic Alpha-Glucosidase Gene and its Use [PDF]

, 2003
Recombinant, thermostable alpha-glucosidases from archaeal micro-organisms and isolated DNA encoding for such alpha-glucosidases are provided. The isolated DNA is obtained by use of DNA or antibody probes prepared from the DNA encoding S.
Blum, Paul
core   +1 more source

Antioxidant Activity and Inhibition of Carbohydrate Hydrolyzing Enzymes by Underutilized Parts From Some Plant‐Based Foods and Their Effect on Postprandial Hyperglycemia

Food Chemistry International, EarlyView.
The underutilized parts viz: pawpaw seed, banana, plantain, and potato peels showed promising antioxidant and inhibition of α‐amylase and α‐glucosidase activities (IC50 values ≤ 100 μg/mL). Similarly, pawpaw seed, banana, plantain, and potato peels reduced postprandial hyperglycemia in sucrose‐ and maltose‐induced hyperglycemia in rats.
Aminu Mohammed, Buhari Shehu Saidu, Nuhu Aliyu, Michael Peter Simon   +3 more
wiley   +1 more source

.ALPHA.-Glucosidase Inhibitor from Bergenia ligulata

Journal of Oleo Science, 2008
Inhibitory compound of alpha-glucosidase activity, (+)-afzelechin (1), was isolated from rhizomes of Bergenia ligulata. The structure was identified by IR, EI-MS, (1)H and (13)C NMR spectroscopy. The ID(50) (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-afzelechin tetraacetate (2), (+)-5,7,
Junichi, Saijyo, Yousuke, Suzuki, Yoshiharu, Okuno, Hidehiko, Yamaki, Takuya, Suzuki, Mitsuo, Miyazawa   +5 more
openaire   +3 more sources

Natural Products as a Potential Enzyme Inhibitors from Medicinal Plants [PDF]

, 2017
Enzyme inhibitory agents are attractive because of their application in treating different ailments. The absence of enzymes produce a number of diseases.
Jehan, Noor, Rauf, Abdur
core   +2 more sources