Results 91 to 100 of about 8,293 (202)

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older‐Age Bipolar Disorder ISBD Task Forces

open access: yesBipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders   +21 more
wiley   +1 more source

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy

open access: yesClinical Genetics, Volume 110, Issue 2, Page 165-171, August 2026.
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk   +13 more
wiley   +1 more source

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

open access: yesCell Proliferation, Volume 59, Issue 8, August 2026.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao   +10 more
wiley   +1 more source

Minoxidil Sulfate Regulates JAK/STAT Signalling and Mitochondrial Function in Alopecia Areata

open access: yesExperimental Dermatology, Volume 35, Issue 8, August 2026.
ABSTRACT Alopecia areata (AA) is an autoimmune hair disorder characterized by interferon‐gamma (IFN‐γ)–driven inflammation and collapse of hair follicle immune privilege. Although Janus kinase (JAK) inhibitors are effective, incomplete or delayed responses remain common. Minoxidil is frequently combined with JAK inhibitors in clinical practice, yet its
Jung‐Min Shin   +5 more
wiley   +1 more source

The Role of Personality in Dyadic Associations Between Stress and Relationship Satisfaction: Findings From the German Cohort Study DREAM

open access: yesJournal of Marriage and Family, Volume 88, Issue 4, Page 1067-1084, August 2026.
ABSTRACT Objective This study investigated whether the associations of own and partner intra‐ and extradyadic stress with relationship satisfaction vary based on both partners' Big Five personality traits among parents. Background Previous research has shown that relationship satisfaction during parenthood often decreases, and increased stress is ...
Saskia Baumgardt   +3 more
wiley   +1 more source

Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta‐Analysis

open access: yesObesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Objective This systematic review and meta‐analysis aimed to identify common life‐course body mass index (BMI) trajectories (childhood/adulthood to adulthood) and their impact on risk of cancer overall and cancer at different sites in adulthood. Methods Observational studies were identified that assessed the association of BMI trajectories with
Samira Behboudi‐Gandevani   +6 more
wiley   +1 more source

Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery

open access: yesInternational Journal of Nanomedicine, 2012
Tatiana A Slastnikova1,2, Andrey A Rosenkranz1,2, Pavel V Gulak1, Raymond M Schiffelers3, Tatiana N Lupanova1,4, Yuri V Khramtsov1, Michael R Zalutsky5, Alexander S Sobolev1,21Laboratory of Molecular Genetics of Intracellular Transport, Institute of Gene
Slastnikova TA   +7 more
doaj  

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