Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma [PDF]
Journal of Translational Medicine, 2023 Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specific expression and involvement in melanocyte ...
Luigi Dall’Olmo +4 more
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α-MSH-induced activation of spinal MC1R but not MC4R enhances colorectal motility in anaesthetised rats [PDF]
Scientific Reports, 2021 The central nervous system is involved in regulation of defaecation. It is generally considered that supraspinal regions control the spinal defaecation centre.
Hiromi H. Ueda +7 more
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Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing [PDF]
BMC Musculoskeletal DisordersBackground Alpha-melanocyte-stimulating-hormone (α-MSH) has been identified as a new anti-inflammatory treatment compound in rheumatoid arthritis (RA) and other inflammatory diseases.
Johanna Graue +7 more
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Binding of cationic analogues of α-MSH to lipopolysaccharide and disruption of the cytoplasmic membranes caused bactericidal action against Escherichia coli [PDF]
Scientific Reports, 2022 In earlier reports, we have shown the antimicrobial activity of a host neuropeptide, alpha-melanocyte stimulating hormone (α-MSH) and its cationic analogues against Staphylococcus aureus.
Kanchan Tiwari +3 more
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Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis [PDF]
Nature Communications, 2023 The immunomodulatory effects of ultraviolet B (UVB) radiation in human diseases have been described. Whether type 2 lung inflammation is directly affected by solar ultraviolet (UV) radiation is not fully understood.
Yuying Huang +23 more
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Tilapia Skin-Derived Peptide PFRMY Attenuates Melanogenesis and Tyrosinase Activity via α-MSH/PKA/CREB Signaling Pathways in B16F10 Murine Melanoma Cells [PDF]
FoodsThe aim of this study was to investigate the anti-melanogenic effects and underlying mechanisms of PFRMY (Pro-Phe-Arg-Met-Tyr), a pentapeptide derived from tilapia skin (Oreochromis niloticus), using B16F10 murine melanoma cells.
Yuqiong Song +7 more
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Altered features of neurotransmitters: NPY, α-MSH, and AgRP in type 2 diabetic patients with hypertension [PDF]
Journal of International Medical Research, 2020 Objective To investigate the features of neuropeptide Y (NPY), α-melanocyte stimulating hormone (α-MSH), and agouti-related protein (AgRP) in type 2 diabetes mellitus (T2DM) patients with hypertension.
Baoxin Li +7 more
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Targeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa [PDF]
npj Biofilms and Microbiomesα-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy ...
Lisa Bremard +6 more
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Activation of the Melanocortin-4 receptor signaling by α-MSH stimulates nerve-dependent mouse digit regeneration [PDF]
Cell Regeneration, 2021 Background Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investigated.
Hanqian Xu +6 more
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α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice. [PDF]
PLoS ONE, 2013 Melanocyte-stimulating hormones, α-, β- and γ-MSH, regulate important physiological functions including energy homeostasis, inflammation and sodium metabolism.
Petteri Rinne +4 more
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