Results 21 to 30 of about 10,932 (154)

Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors

Cell Discovery, 2023
Members of the melanocortin receptor (MCR) family that recognize different melanocortin peptides mediate a broad spectrum of cellular processes including energy homeostasis, inflammation and skin pigmentation through five MCR subtypes (MC1R–MC5R).
Wenbo Feng, Qingtong Zhou, Xianyue Chen, Antao Dai, Xiaoqing Cai, Xiao Liu, Fenghui Zhao, Yan Chen, Chenyu Ye, Yingna Xu, Zhaotong Cong, Hao Li, Shi Lin, Dehua Yang, Ming-Wei Wang   +14 more
doaj   +1 more source

The pharmacological properties of 3-arm or 4-arm DOTA constructs for conjugation to α-melanocyte-stimulating hormone analogues for melanoma imaging.

PLoS ONE, 2019
BackgroundAlthough a 3-arm DOTA construct, which has three carboxylic acids, h has been applied for conjugation to many peptides, we investigated if a 4-arm DOTA construct conjugated to peptides improves chemical properties for melanoma imaging of the ...
Masato Kobayashi, Toshitaka Kato, Kohshin Washiyama, Masaaki Ihara, Asuka Mizutani, Kodai Nishi, Leo G Flores, Ryuichi Nishii, Keiichi Kawai   +8 more
doaj   +1 more source

In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice

Molecular Brain, 2009
Background In vitro reactions are useful to identify putative enzyme substrates, but in vivo validation is required to identify actual enzyme substrates that have biological meaning. To investigate in vivo effects of prolyl endopeptidase (PREP), a serine
Perroud Bertrand, Alvarado Rudy J, Espinal Glenda M, Morado Alex R, Phinney Brett S, Warden Craig H   +5 more
doaj   +1 more source

The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells

Journal of Transplantation, 2011
The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) has an important role in modulating immunity and homeostasis. The production of IFN-γ by effector T cells is suppressed by α-MSH, while TGF-β production is promoted in the same cells.
Andrew W. Taylor, Darren J. Lee
doaj   +1 more source

Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone [PDF]

PeerJ, 2018
The blood–brain barrier (BBB), an interface between the systemic circulation and the nervous system, can be a target of cytokines in inflammatory conditions.
András Harazin, Alexandra Bocsik, Lilla Barna, András Kincses, Judit Váradi, Ferenc Fenyvesi, Vilmos Tubak, Maria A. Deli, Miklós Vecsernyés   +8 more
doaj   +2 more sources

Excited‐State Antiaromaticity in Nonbenzenoid Aromatics: Examining the Dynamics of Intramolecular Proton Transfer With a Small Driving Force

Angewandte Chemie, EarlyView.
The excited‐state antiaromaticity of hydroxybenzotropyliums (HBTs) can be tuned through substituent effects to bring the aromatic ‘enol’ (E) and keto (K) tautomers close in energy. This leads to abnormally slow excited‐state proton transfer (on the ns timescale), giving rise to dual fluorescence emission and weak photoacidity.
Promeet K. Saha, Charlotte A. Bardsley, Hector G. Miranda‐Salinas, Daniel Crane, Rabia Ayub, Andrew P. Monkman, Paul R. McGonigal   +6 more
wiley   +2 more sources

Short-term effects of α-melanocyte-stimulating hormone in three distinct melanin-pigmented cell types of Anura [PDF]

Anais da Academia Brasileira de Ciências, 2022
Ectothermic animals present melanin-containing cells in their integument and viscera. Besides cutaneous melanophores, amphibians have melanomacrophages in the hepatic parenchyma and melanocytes in the viscera, which are also present in their testicular ...
RODRIGO ZIERI, LILIAN FRANCO-BELUSSI, CLASSIUS DE OLIVEIRA   +2 more
doaj   +1 more source

[Nle4, D-Phe7]-α-MSH Inhibits Toll-Like Receptor (TLR)2- and TLR4-Induced Microglial Activation and Promotes a M2-Like Phenotype. [PDF]

PLoS ONE, 2016
α-melanocyte stimulating hormone (α-MSH) is an anti-inflammatory peptide, proved to be beneficial in many neuroinflammatory disorders acting through melanocortin receptor 4 (MC4R).
Lila Carniglia, Delia Ramírez, Daniela Durand, Julieta Saba, Carla Caruso, Mercedes Lasaga   +5 more
doaj   +1 more source

α-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes.

PLoS ONE, 2014
AimsOxidative stress and apoptosis are among the earliest lesions of diabetic retinopathy. This study sought to examine the anti-oxidative and anti-apoptotic effects of α-melanocyte-stimulating hormone (α-MSH) in early diabetic retinas and to explore the
Lijuan Zhang, Lijie Dong, Xun Liu, Yuanfeng Jiang, Lingjun Zhang, Xiaomin Zhang, Xiaorong Li, Yan Zhang   +7 more
doaj   +1 more source

Inhibition of Melanogenesis via Passive Immune Targeted Alpha-MSH Binder Polypeptide

Cosmetics
Alpha-melanocyte stimulating hormone (α-MSH) is a hormone that stimulates the formation of melanin, which is responsible for protecting the skin from UV rays.
Se-Hyo Jeong, Hun-Hwan Kim, Abigail Joy D. Rodelas-Angelia, Mark Rickard N. Angelia, Pritam Bhagwan Bhosale, Eun-Hye Kim, Tae-Sung Jung, Mee-Jung Ahn, Gon-Sup Kim   +8 more
doaj   +1 more source