Results 11 to 20 of about 1,060,115 (160)

Additive Manufacturing of High‐Performance Polymers for Extreme Environments

Advanced Science, EarlyView.
Additive manufacturing of high‐performance polymers for extreme environments is critically reviewed through an integrated chemistry‐processing‐structure‐property‐qualification framework. The review compares fused filament fabrication, selective laser sintering, and direct ink writing, linking rheology and thermal history to crystallization, defect ...
Md Tofazzal Hossain, Mohammed Intishar Nur, Md Shajedul Hoque Thakur, Indranil Dey, Md Mesbahul Maruf, Md Jahid Hasan, Suryasarathi Bose, Muhammad M. Rahman   +7 more
wiley   +1 more source

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis [PDF]

, 2018
OBJECTIVE: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins.
Larraufie, P, Bartels, T, Kirwan, P, Reimann, F, White, A, Gribble, FM, Merkle, FT, Farooqi, IS, Brouwers, B, O'Rahilly, S, Herranz-Pérez, V, Jura, M, Kay, RG, Jerber, J, Pembroke, J   +14 more
core   +3 more sources

Effects of AgRP and TTP2515 on α-MSH-induced cAMP production.

, 2013
(A) α-MSH-induced cAMP production in HEK293 cells overexpressing human MC4R (green diamond); inhibition of α-MSH(3 nM)-induced cAMP production by increasing amounts of AgRP (pink diamond) (B) α-MSH-induced cAMP production in HEK293 cells overexpressing ...
Robert Rothlein (418717), Matthew Modes (418716), Ye Edward Tian (418719), Sam F. Victory (418721), Carmen Valcarce (418722), Jane M. Shen (418718), Andrea J. Kim (418715), Jumana Ihbais (418720), Roxanne Dutia (418714), Sharon L. Wardlaw (418723)   +9 more
core   +1 more source

Bio‐Inspired Internal Stress Engineering for Microscale Surface Cracking in Sensitive Strain Sensors

Advanced Science, EarlyView.
This study presents a bio‐inspired internal stress engineering strategy to fabricate highly sensitive crack‐based strain sensors. By harnessing the internal expansion energy of microspheres and the thickness‐dependent brittle‐to‐ductile transition of ultrathin gold films, tunable microscale cracks are generated.
Jae Yeong Jang, Hanchul Cho, Young Jung
wiley   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

α-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line

, 1996
α-Melanocyte-stimulating hormone (α-MSH), a tridecapeptide derived from pro-opiomelanocortin, has potent antiinflammatory activity in laboratory animals.
A Catania, R A Star, G Ceriani, N Rajora, M T Murphy, J M Lipton   +5 more
core   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

Antimicrobial effects of α-MSH peptides

, 2000
The presence of the ancient antiinflammatory peptide α-melanocyte-stimulating hormone [α-MSH (1–13), SYSMEHFRWGKPV] in barrier organs such as gut and skin suggests a role in the nonspecific (innate) host defense.
Anna Catania, Mariagrazia Cutuli, Silvia Cristiani, James M Lipton   +3 more
core   +1 more source

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

Distribution of 3H-α-MSH in rat brain

, 1976
Radioactive synthetic α-MSH, prepared by selective tritiation of its dibromo-L-tyrosine 2-derivative, was injected into the carotid artery of intact, hypophysectomized or pinealectomized rats.
Coy, David H, Kastin, Abba J, Schally, Andrew V, Nikolics, Karoly, Teplan, Istvan, Medzihradszky, Kalmen, Nissen, Cheryl   +6 more
core   +1 more source