Results 31 to 40 of about 16,479 (196)

Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling [PDF]

, 2017
In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-derived peptide α–melanocytestimulating hormone (α-MSH) promote satiety. POMC neurons receive orexin-A (OX-A)-expressing inputs and express both OX-A receptor type
Buono, Lorena, Cristino, Luigia, Morello, Giovanna   +2 more
core   +1 more source

The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells

Journal of Transplantation, 2011
The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) has an important role in modulating immunity and homeostasis. The production of IFN-γ by effector T cells is suppressed by α-MSH, while TGF-β production is promoted in the same cells.
Andrew W. Taylor, Darren J. Lee
doaj   +1 more source

Short-term effects of α-melanocyte-stimulating hormone in three distinct melanin-pigmented cell types of Anura [PDF]

Anais da Academia Brasileira de Ciências, 2022
Ectothermic animals present melanin-containing cells in their integument and viscera. Besides cutaneous melanophores, amphibians have melanomacrophages in the hepatic parenchyma and melanocytes in the viscera, which are also present in their testicular ...
RODRIGO ZIERI, LILIAN FRANCO-BELUSSI, CLASSIUS DE OLIVEIRA   +2 more
doaj   +1 more source

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]

, 2019
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano, Apte, Bill, Blom, Brigida Anna Maiorano, De Vries, Durie, Emilio Bria, Ericsson, Ernesto Rossi, Giampaolo Tortora, Gianluigi Petrone, Giovanni Schinzari, Guido Rindi, Ilaria Grazia Zizzari, Lagouros, Makitie, Maria Antonietta Blasi, Maria Grazia Sammarco, Marianna Nuti, Monica Maria Pagliara, Shaw, Sohn, Vincenzo Fiorentino, Whelchel   +24 more
core   +1 more source

[Nle4, D-Phe7]-α-MSH Inhibits Toll-Like Receptor (TLR)2- and TLR4-Induced Microglial Activation and Promotes a M2-Like Phenotype. [PDF]

PLoS ONE, 2016
α-melanocyte stimulating hormone (α-MSH) is an anti-inflammatory peptide, proved to be beneficial in many neuroinflammatory disorders acting through melanocortin receptor 4 (MC4R).
Lila Carniglia, Delia Ramírez, Daniela Durand, Julieta Saba, Carla Caruso, Mercedes Lasaga   +5 more
doaj   +1 more source

Conflict between background matching and social signalling in a colour-changing freshwater fish [PDF]

, 2016
The ability to change coloration allows animals to modify their patterning to suit a specific function. Many freshwater fishes, for example, can appear cryptic by altering the dispersion of melanin pigment in the skin to match the visual background ...
Kelley, Jennifer L., Morrell, Lesley J., Rodgers, Gwendolen M.   +2 more
core   +3 more sources

α-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes.

PLoS ONE, 2014
AimsOxidative stress and apoptosis are among the earliest lesions of diabetic retinopathy. This study sought to examine the anti-oxidative and anti-apoptotic effects of α-melanocyte-stimulating hormone (α-MSH) in early diabetic retinas and to explore the
Lijuan Zhang, Lijie Dong, Xun Liu, Yuanfeng Jiang, Lingjun Zhang, Xiaomin Zhang, Xiaorong Li, Yan Zhang   +7 more
doaj   +1 more source

Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone [PDF]

PeerJ, 2018
The blood–brain barrier (BBB), an interface between the systemic circulation and the nervous system, can be a target of cytokines in inflammatory conditions.
András Harazin, Alexandra Bocsik, Lilla Barna, András Kincses, Judit Váradi, Ferenc Fenyvesi, Vilmos Tubak, Maria A. Deli, Miklós Vecsernyés   +8 more
doaj   +2 more sources

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury [PDF]

, 2014
Introduction Mechanical injury can greatly influence articular cartilage, propagating inflammation, cell injury and death – risk factors for the development of osteoarthritis.
Alexander, Baker, Bazzani, Bazzani, Berenbaum, Blanco, Bohm, Borrelli, Brown, Buckley, Buckley, Buckwalter, Bush, Carames, Carman, Catania, Ceriani, Daniel, Del Carlo, D’Lima, D’Lima, Elsaid, Ferguson, Fernandes, Ferretti, G. Paul Curley, Gelber, Getting, Getting, Getting, Getting, Getting, Getting, Giuliani, Glyn, Gosset, Grassel, Grieco, Guarini, Guarini, Hashimoto, Heraud, Holloway, Hruby, Huang, Ian C. Locke, Intekhab-Alam, Kaneva, Kannengiesser, Kerrigan, Kim, Kobayashi, Kurz, Lam, Land, Lawrence, Lawrence, Lee, Lefkowitz, Levin, Lohmander, Lohmander, Lu, Magdalena K. Kaneva, Majewski, Mark J.P. Kerrigan, Martel-Pelletier, Mioni, Montero-Melendez, Muceniece, Muller, Murphy, Oppenheimer, Ottani, Paolo Grieco, Patel, Phillips, Quinn, Raap, Rai, Rajora, Roos, Scanzello, Shlopov, Spaccapelo, Spaccapelo, Stephen J. Getting, Stockwell, Surendran, Szczodry, Westin, Wilder, Yoon, Zhou   +93 more
core   +1 more source

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. [PDF]

, 2015
Objective Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin receptors (MC) has previously shown to inhibit leukocyte recruitment in peripheral inflammation ...
Cooper, D., Cooper, D., Cvek, U., Cvek, U., Durrenberger, P.F., Durrenberger, P.F., Gavins, F.N., Gavins, F.N., Getting, S.J., Getting, S.J., Holloway, P.M., Holloway, P.M., Orr, A.W., Orr, A.W., Perretti, M., Perretti, M., Trutschl, M., Trutschl, M.   +17 more
core   +1 more source