Results 51 to 60 of about 1,060,115 (160)

Dopamine release in the lateral hypothalamus is stimulated by α-MSH in both the anticipatory and consummatory phases of feeding

, 2015
International audienceα-Melanocyte-stimulating hormone (α-MSH), is a hypothalamic neuropeptide signaling satiation, but it is not known if α-MSH may stimulate dopamine release in a feeding control brain region of the lateral hypothalamic area (LHA ...
Lucas, Nicolas, Déchelotte, Pierre, Fetissov, Sergueï, O., Legrand, Romain, Breton, Jonathan   +4 more
core   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

The orphan G protein-coupled receptor GPR139 is activated by the peptides:Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW [PDF]

, 2017
GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is activated by the amino acids l-tryptophan and l-phenylalanine (EC50 values ...
Shehata, Mohamed A, Pedersen, Daniel Sejer, Gloriam, David E, Mokrosinski, Jacek, Bräuner-Osborne, Hans, Jensen, Anne Cathrine Nøhr, Hauser, Alexander S, Farooqi, I Sadaf, Isberg, Vignir   +8 more
core   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2181-2198, October 2026.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

α-MSH and its receptors in regulation of tumor necrosis factor-α production by human monocyte/macrophages

, 1999
The hypothesis that macrophages contain an autocrine circuit based on melanocortin [ACTH and α-melanocyte-stimulating hormone (α-MSH)] peptides has major implications for neuroimmunomodulation research and inflammation therapy.
L. Kelly, A. Catania, S. Sharma, V. Chhajlani, I. Gantz, H. Zhao, S. Taherzadeh, T. Ichiyama, J. M. Lipton, N. Rajora, M. T. Demitri   +10 more
core   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source

Local Adaptation With Gene Flow Has a Polygenic Basis in a Threatened Coastal Songbird

Ecology and Evolution, Volume 16, Issue 10, October 2026.
Using a new chromosome‐level reference genome and whole‐genome sequencing, we show that the threatened, coastally specialized Atlantic song sparrow (Melospiza melodia atlantica) maintains adaptive divergence from a widespread generalist subspecies with divergently selected loci scattered across the genome rather than concentrated in low‐recombination ...
Jonathan D. Clark, Haw Chuan Lim, Brian J. Olsen, Adrienne I. Kovach   +3 more
wiley   +1 more source

Effect of α-MSH on LDH.

, 2014
At ten hours post-reperfusion LDH was higher in α-MSH treated animals compared to controls (Figure 7 ...
Yahor Chynau (550696), Henri G. D. Leuvenink (167159), Niels Secher (550693), Rikke Nørregaard (550698), Henrik Birn (174805), Ulla Møldrup (550695), Harry van Goor (18163), Anna K. Keller (550694), Søren Nielsen (155815), Bente Jespersen (550700), Willem G. van Rijt (550692), Jørgen Frøkiaer (550699), Rutger J. Ploeg (550697)   +12 more
core   +1 more source

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance. [PDF]

, 2018
OBJECTIVE: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance ...
Botha, Rikus, Piper, Sarah J, Coll, Anthony P, Joel K. Elmquist, Hubbard, Kristina, Harris, Paul W.R., Elmquist, Joel K., Martin Middleditch, Shome, Avik, Syann Lee, Ailsa McGregor, Rikus Botha, Anthony P. Coll, Bould, Sarah, Kristina Hubbard, Coll, Anthony P., Tan, Karen ML, Mountjoy, Kathleen G., Sarah Bould, Margaret A. Brimble, Piper, Sarah J., Renata Kowalczyk, Christina Buchanan, McGregor, Ailsa, Angus C. Grey, Caron, Alexandre, Pontré, Beau, Lee, Syann, Sarah J. Piper, Sun, Bo, Middleditch, Martin, Beau Pontré, Karen M.L. Tan, Buchanan, Christina, Avik Shome, Tan, Karen M.L., Kowalczyk, Renata, Bo Sun, Brimble, Margaret A., Paul W.R. Harris, Kathleen G. Mountjoy, Elmquist, Joel K, Alexandre Caron, Grey, Angus C., Mountjoy, Kathleen G, Brimble, Margaret A, Grey, Angus C, Harris, Paul WR   +47 more
core   +2 more sources

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source