Results 51 to 60 of about 10,932 (154)

α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor

EMBO Reports
α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). However, the role of α-MSH and its possible target receptors in the heart remain completely unknown.
Anni Suominen, Guillem Saldo Rubio, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Bishwa Ghimire, Suvi T Ruohonen, Karla Saukkonen, Jani Ijas, Sini Skarp, Leena Kaikkonen, Minying Cai, Sharon L Wardlaw, Heikki Ruskoaho, Virpi Talman, Eriika Savontaus, Risto Kerkelä, Petteri Rinne   +17 more
doaj   +1 more source

Α-Melanocyte-Stimulating Hormone Protects Early Diabetic Retina from Blood-Retinal Barrier Breakdown and Vascular Leakage via MC4R

Cellular Physiology and Biochemistry, 2018
Background/Aims: Blood-retinal barrier (BRB) breakdown and vascular leakage is the leading cause of blindness of diabetic retinopathy (DR). Hyperglycemia-induced oxidative stress and inflammation are primary pathogenic factors of this severe DR ...
Siwei Cai, Qianhui Yang, Mengzhu Hou, Qian Han, Hanyu Zhang, Jiantao Wang, Chen Qi, Qiyu Bo, Yusha Ru, Wei Yang, Zhongxiu Gu, Ruihua Wei, Yunshan Cao, Xiaorong Li, Yan Zhang   +14 more
doaj   +1 more source

Thin‐layer drying kinetics and mathematical modelling of osmotically pretreated vacuum dried green chilli

JSFA reports, EarlyView.
Abstract Background Chilli is highly perishable, often requiring drying to extend shelf life. This study assesses and compares the drying kinetics of osmotically pretreated green chilli under vacuum drying conditions while evaluating suitable mathematical models and calculating effective moisture diffusivity and activation energy. Results Sliced chilli
Md. Raihanul Haque, Md. Iftekhar Kabir, Md. Nahidul Islam, Md. Mojaffor Hosain, Md. Sazzat Hossain Sarker   +4 more
wiley   +1 more source

Impact of hamstring versus quadriceps tendon graft on thigh muscle strength and surface electromyography activity after anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare quadriceps tendon (QT) and hamstring tendon (HT) autografts regarding isometric thigh muscle strength, surface electromyography (sEMG) activity and clinical outcomes following anterior cruciate ligament reconstruction (ACLR).
Benjamin Forquignon, Tobias Drenck, Matthias Krause, Ralph Akoto, Karl‐Heinz Frosch, Götz Welsch, Alexander Korthaus, Grégoire Thürig, Dimitris Dalos   +8 more
wiley   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

From Growing Conditions to Composite Performance: Acid‐Engineered Algerian Sisal Fibers for Sustainable Bio‐Epoxy Composites

Polymer Composites, EarlyView.
High‐Performance Sustainable Ski Core Bio‐Composite Derived from Bio‐Epoxy and Sisal Sibers Systems. ABSTRACT In pursuit of sustainable and high‐performance materials, this work investigates the potential of Algerian sisal fibers as renewable reinforcements in bio‐epoxy composites.
M. A. Kacem, R. Halimi, O. Duncan, T. Allen, M. Bodaghi   +4 more
wiley   +1 more source

Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death

Biomolecules
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis.
Shudan Wang, Francesca Kahale, Amirreza Naderi, Pier Luigi Surico, Jia Yin, Thomas Dohlman, Yihe Chen, Reza Dana   +7 more
doaj   +1 more source

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis

Molecular Metabolism, 2018
Objective: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins.
Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M. Gribble, Frank Reimann, I. Sadaf Farooqi, Stephen O'Rahilly, Florian T. Merkle   +14 more
doaj   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Learning Across the Divide: Understanding Knowledge Sharing Through Petrographic Analysis on Ceramics From the Rhine‐Meuse Delta During the Middle to Late Neolithic Transition (3400–2200 bce)

Archaeometry, EarlyView.
ABSTRACT Vlaardingen (VL) communities on the Dutch West coast (3400–2200 bce) are part of a unique, long‐term continuity in the European Neolithic. Despite large‐scale changes in European populations during the Neolithic, the genomic diversity and cultural practices of VL communities can be retraced to the Mesolithic.
Jisca de Bruin, Erik Kroon, Lasse van den Dikkenberg, Dennis Braekmans   +3 more
wiley   +1 more source