Results 1 to 10 of about 29,401 (218)

Anti-inflammatory α-Melanocyte-Stimulating Hormone Protects Retina After Ischemia/Reperfusion Injury in Type I Diabetes [PDF]

Frontiers in Neuroscience, 2022
Retinal ischemia/reperfusion (I/R) injury is a major cause of vision loss in many ocular diseases. Retinal I/R injury is common in diabetic retinopathy, which as a result of hyperglycemia damages the retina and can cause blindness if left untreated ...
Rajesh Kumar Goit, Andrew W. Taylor, Amy C. Y. Lo   +2 more
doaj   +3 more sources

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance [PDF]

Molecular Metabolism, 2018
Objective: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance ...
Kathleen G. Mountjoy, Alexandre Caron, Kristina Hubbard, Avik Shome, Angus C. Grey, Bo Sun, Sarah Bould, Martin Middleditch, Beau Pontré, Ailsa McGregor, Paul W.R. Harris, Renata Kowalczyk, Margaret A. Brimble, Rikus Botha, Karen M.L. Tan, Sarah J. Piper, Christina Buchanan, Syann Lee, Anthony P. Coll, Joel K. Elmquist   +19 more
doaj   +3 more sources

Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone [PDF]

PeerJ, 2018
The blood–brain barrier (BBB), an interface between the systemic circulation and the nervous system, can be a target of cytokines in inflammatory conditions.
András Harazin, Alexandra Bocsik, Lilla Barna, András Kincses, Judit Váradi, Ferenc Fenyvesi, Vilmos Tubak, Maria A. Deli, Miklós Vecsernyés   +8 more
doaj   +4 more sources

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors [PDF]

Molecular Metabolism, 2016
Objective: Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a
Pablo J. Enriori, Weiyi Chen, Maria C. Garcia-Rudaz, Bernadette E. Grayson, Anne E. Evans, Sarah M. Comstock, Ursel Gebhardt, Hermann L. Müller, Thomas Reinehr, Belinda A. Henry, Russell D. Brown, Clinton R. Bruce, Stephanie E. Simonds, Sara A. Litwak, Sean L. McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H. Tschöp, Matthew J. Watt, Iain J. Clarke, Christian L. Roth, Kevin L. Grove, Michael A. Cowley   +23 more
doaj   +3 more sources

The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines [PDF]

Journal of Experimental & Clinical Cancer Research, 2017
Background The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway.
Enrica Flori, Eleonora Rosati, Giorgia Cardinali, Daniela Kovacs, Barbara Bellei, Mauro Picardo, Vittoria Maresca   +6 more
doaj   +3 more sources

Pinostrobin Suppresses the α-Melanocyte-Stimulating Hormone-Induced Melanogenic Signaling Pathway. [PDF]

Int J Mol Sci, 2023
Pinostrobin is a dietary flavonoid found in several plants that possesses pharmacological properties, such as anti-cancer, anti-virus, antioxidant, anti-ulcer, and anti-aromatase effects.
Athapaththu AMGK, Sanjaya SS, Lee KT, Karunarathne WAHM, Choi YH, Hur SP, Kim GY.   +6 more
europepmc   +2 more sources

α‐Melanocyte‐stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation [PDF]

Physiological Reports, 2022
Oxytocin is secreted into the periphery by magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei (SON and PVN) to trigger uterine contraction during birth and milk ejection during suckling.
Michael R. Perkinson, Matthew K. Kirchner, Meng Zhang, Rachael A. Augustine, Javier E. Stern, Colin H. Brown   +5 more
doaj   +2 more sources

7,3',4'-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses α-Melanocyte-Stimulating Hormone-Induced Melanogenesis by Targeting Melanocortin 1 Receptor. [PDF]

Front Mol Biosci, 2020
7,3′,4′-Trihydroxyisoflavone (7,3′,4′-THIF) is a metabolite of daidzein which is a representative isoflavone found in soybean. Recent studies suggested that 7,3′,4′-THIF exerts a hypopigmentary effect in B16F10 cells, however, its underlying molecular ...
Kim JH, Lee JE, Kim T, Yeom MH, Park JS, di Luccio E, Chen H, Dong Z, Lee KW, Kang NJ.   +9 more
europepmc   +2 more sources

Targeted melanoma radiotherapy using ultrasmall ¹⁷⁷Lu-labeled α-melanocyte stimulating hormone-functionalized core-shell silica nanoparticles. [PDF]

Biomaterials, 2020
Lutetium-177 (177Lu) radiolabeled ultrasmall (~6 nm dia.) fluorescent core-shell silica nanoparticles (Cornell prime dots or C' dots) were developed for improving efficacy of targeted radiotherapy in melanoma models.
Zhang X, Chen F, Turker MZ, Ma K, Zanzonico P, Gallazzi F, Shah MA, Prater AR, Wiesner U, Bradbury MS, McDevitt MR, Quinn TP.   +11 more
europepmc   +2 more sources

MicroRNA-141-3p and microRNA-200a-3p regulate α-melanocyte stimulating hormone-stimulated melanogenesis by directly targeting microphthalmia-associated transcription factor. [PDF]

Sci Rep, 2020
In recent years, it has been reported that non-coding RNAs, especially microRNAs (miRNAs) and long non-coding RNAs, act as melanogenesis-regulating molecules in melanocytes. We found that the expression levels of miR-141-3p and miR-200a-3p were decreased
Itoh T, Fukatani K, Nakashima A, Suzuki K.   +3 more
europepmc   +2 more sources