Results 11 to 20 of about 9,448 (137)

Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma

Journal of Translational Medicine, 2023
Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specific expression and involvement in melanocyte ...
Luigi Dall’Olmo, Nicole Papa, Nicoletta Concetta Surdo, Ilaria Marigo, Simone Mocellin   +4 more
doaj   +1 more source

Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617

Marine Drugs, 2022
The tricyclic quinazoline alkaloid deoxyvasicinone (DOV, 1) was isolated from a marine-derived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated.
Se-eun Lee, Min-ju Kim, Prima F. Hillman, Dong-Chan Oh, William Fenical, Sang-Jip Nam, Kyung-Min Lim   +6 more
doaj   +1 more source

In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice

Molecular Brain, 2009
Background In vitro reactions are useful to identify putative enzyme substrates, but in vivo validation is required to identify actual enzyme substrates that have biological meaning. To investigate in vivo effects of prolyl endopeptidase (PREP), a serine
Perroud Bertrand, Alvarado Rudy J, Espinal Glenda M, Morado Alex R, Phinney Brett S, Warden Craig H   +5 more
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Effect of Phlorotannins Isolated From on Melanogenesis in Mouse B16 Melanoma Cells

Natural Product Communications, 2021
Phlorotannins isolated from brown algae, such as Eisena bicyclis , have positive physiological effects, including anti-cancer, anti-inflammatory, and anti-Alzheimer’s disease.
Yuki Ohno, Shiori Kondo, Kiho Tajima, Toshiyuki Shibata, Tomohiro Itoh   +4 more
doaj   +1 more source

Short-term effects of α-melanocyte-stimulating hormone in three distinct melanin-pigmented cell types of Anura [PDF]

Anais da Academia Brasileira de Ciências, 2022
Ectothermic animals present melanin-containing cells in their integument and viscera. Besides cutaneous melanophores, amphibians have melanomacrophages in the hepatic parenchyma and melanocytes in the viscera, which are also present in their testicular ...
RODRIGO ZIERI, LILIAN FRANCO-BELUSSI, CLASSIUS DE OLIVEIRA   +2 more
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Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

Acta Pharmaceutica Sinica B, 2014
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L.
Ryuji Uchida, Seiko Ishikawa, Hiroshi Tomoda   +2 more
doaj   +1 more source

The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes

Cell Death Discovery, 2021
Variants in the melanocortin-1 receptor (MC1R) gene, encoding a trimeric G-protein-coupled receptor and activated by α-melanocyte-stimulating hormone (α-MSH), are frequently associated with red or blonde hair, fair skin, freckling, and skin sensitivity ...
Xin Li, Weiwei Mao, Jie Chen, Colin R. Goding, Rutao Cui, Zhi-Xiang Xu, Xiao Miao   +6 more
doaj   +1 more source

Sargahydroquinoic Acid Suppresses Hyperpigmentation by cAMP and ERK1/2-Mediated Downregulation of MITF in α-MSH-Stimulated B16F10 Cells

Foods, 2021
Hyperpigmentation diseases of the skin require topical treatment with depigmenting agents. We investigated the hypopigmented mechanisms of sargahydroquinoic acid (SHQA) in alpha-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 cells. SHQA reduced
Mohammed Shariful Azam, Jae-Il Kim, Chang Geun Choi, Jinkyung Choi, Bonggi Lee, Hyeung-Rak Kim   +5 more
doaj   +1 more source

Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.

PLoS ONE, 2016
Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical ...
Guillaume Le Saux, Laurent Plawinski, Sylvain Nlate, Jean Ripoche, Thierry Buffeteau, Marie-Christine Durrieu   +5 more
doaj   +1 more source

Keratinocytes regulate the function of melanocytes

Dermatologica Sinica, 2014
Mammalian keratinocytes compose the bulk of the epithelium, undergo keratinization, and form the dead superficial layer of the skin. These superficial keratinized cells are continuously replaced by cells derived from mitotic cells in the lowest layer of ...
Tomohisa Hirobe
doaj   +1 more source