Results 11 to 20 of about 29,401 (218)

Syringaresinol Attenuates α-Melanocyte-Stimulating Hormone-Induced Reactive Oxygen Species Generation and Melanogenesis [PDF]

Antioxidants
Ginseng has been utilized for centuries in both the medicinal and cosmetic realms. Recent studies have actively investigated the biological activity of ginseng berry and its constituents. (+)-Syringaresinol [(+)-SYR], an active component of ginseng berry,
Kyuri Kim, Jihyun Yoon, Kyung-Min Lim
doaj   +2 more sources

α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor [PDF]

EMBO Reports
α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). However, the role of α-MSH and its possible target receptors in the heart remain completely unknown.
Anni Suominen, Guillem Saldo Rubio, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Bishwa Ghimire, Suvi T Ruohonen, Karla Saukkonen, Jani Ijas, Sini Skarp, Leena Kaikkonen, Minying Cai, Sharon L Wardlaw, Heikki Ruskoaho, Virpi Talman, Eriika Savontaus, Risto Kerkelä, Petteri Rinne   +17 more
doaj   +2 more sources

Effect of 3,6-anhydro-l-galactose on α-melanocyte stimulating hormone-induced melanogenesis in human melanocytes and a skin-equivalent model. [PDF]

J Cell Biochem, 2018
3,6‐Anhydro‐l‐galactose (l‐AHG) is a bioactive sugar that is a major component of agarose. Recently, l‐AHG was reported to have anti‐melanogenic potential in human epidermal melanocytes (HEMs) and B16F10 melanoma cells; however, its underlying molecular ...
Kim JH, Kim DH, Cho KM, Kim KH, Kang NJ.
europepmc   +2 more sources

Preclinical Melanoma Imaging with ⁶⁸Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET. [PDF]

Theranostics, 2017
It is estimated that melanoma accounted for 76,380 new cases and 10,130 deaths in the United States in 2016. The melanocortin 1 receptor (MC1R) is highly expressed in the vast majority of melanomas, which makes it an attractive target for molecular ...
Zhang C, Zhang Z, Lin KS, Pan J, Dude I, Hundal-Jabal N, Colpo N, Bénard F.   +7 more
europepmc   +2 more sources

Construction of a Tandem Repeat Peptide Sequence with Pepsin Cutting Sites to Produce Recombinant α-Melanocyte-Stimulating Hormone [PDF]

Molecules, 2021
The production of α-melanocyte-stimulating hormone (α-MSH), a peptide hormone composed of 13 amino acids, is attempted by recombinant expression using E. coli as the host. To achieve this aim, a synthetic gene containing eight tandem repeats of msh gene (
Dai-Lin Jiang, Chao-Ling Yao, Nien-Jen Hu, Yung-Chuan Liu   +3 more
doaj   +2 more sources

Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced ²²⁵Ac. [PDF]

EJNMMI Radiopharm Chem, 2019
BackgroundActinium-225 (225Ac, t1/2 = 9.9 d) is a promising candidate radionuclide for use in targeted alpha therapy (TAT), though the currently limited global supply has hindered the development of a suitable Ac-chelating ligand and 225Ac ...
Ramogida CF, Robertson AKH, Jermilova U, Zhang C, Yang H, Kunz P, Lassen J, Bratanovic I, Brown V, Southcott L, Rodríguez-Rodríguez C, Radchenko V, Bénard F, Orvig C, Schaffer P.   +14 more
europepmc   +2 more sources

Downregulation of α-Melanocyte-Stimulating Hormone-Induced Activation of the Pax3-MITF-Tyrosinase Axis by Sorghum Ethanolic Extract in B16F10 Melanoma Cells. [PDF]

Int J Mol Sci, 2018
Ultraviolet irradiation-induced hyperpigmentation of the skin is associated with excessive melanin production in melanocytes. Tyrosinase (TYR) is a key enzyme catalyzing the rate-limiting step in melanogenesis.
Lee DH, Ahn SS, Kim JB, Lim Y, Lee YH, Shin SY.   +5 more
europepmc   +2 more sources

Effect of Centrally Administered Neuropeptide Y and α-Melanocyte-stimulating Hormone on Water Intake in Chicks [PDF]

The Journal of Poultry Science
From an animal welfare perspective, thirst avoidance is an important criterion for the poultry industry. Neuropeptide Y (NPY) and α−melanocyte-stimulating hormone (α-MSH) play critical roles in regulating food intake, which is closely related to water ...
Nnamdi Godswill Dialoke, Kaoruko Murata, Yuhui Zhang, Yuji Taniguchi, Sei-ichi Hinomoto, Junya Takegaki, Takaoki Saneyasu, Kazuhisa Honda   +7 more
doaj   +2 more sources

Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis [PDF]

Cell Reports, 2015
Alterations in ER homeostasis have been implicated in the pathophysiology of obesity and type-2 diabetes (T2D). Acute ER stress induction in the hypothalamus produces glucose metabolism perturbations.
Marc Schneeberger, Alicia G. Gómez-Valadés, Jordi Altirriba, David Sebastián, Sara Ramírez, Ainhoa Garcia, Yaiza Esteban, Anne Drougard, Albert Ferrés-Coy, Analía Bortolozzi, Pablo M. Garcia-Roves, John G. Jones, Bruno Manadas, Antonio Zorzano, Ramon Gomis, Marc Claret   +15 more
doaj   +2 more sources

Oleoylethanolamide inhibits α-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells. [PDF]

Oncotarget, 2017
The present study aimed to examine the potential inhibitory activity of oleoylethanolamide (OEA) on α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis and the molecular mechanism(s) involved in the process in B16 mouse melanoma cells.
Zhou J, Ren T, Li Y, Cheng A, Xie W, Xu L, Peng L, Lin J, Lian L, Diao Y, Jin X, Yang L.   +11 more
europepmc   +2 more sources