Results 31 to 40 of about 29,401 (218)
Molecular Brain, 2009 Background In vitro reactions are useful to identify putative enzyme substrates, but in vivo validation is required to identify actual enzyme substrates that have biological meaning. To investigate in vivo effects of prolyl endopeptidase (PREP), a serine
Perroud Bertrand +5 more
doaj +1 more source
Modulation of social behavior by the agouti pigmentation gene [PDF]
, 2014 Agouti is a secreted neuropeptide that acts as an endogenous antagonist of melanocortin receptors. Mice and rats lacking agouti (called non-agouti) have dark fur due to a disinhibition of melanocortin signaling and pigment deposition in the hair follicle.
Carola V +5 more
core +1 more source
Effect of Phlorotannins Isolated From on Melanogenesis in Mouse B16 Melanoma Cells
Natural Product Communications, 2021 Phlorotannins isolated from brown algae, such as Eisena bicyclis , have positive physiological effects, including anti-cancer, anti-inflammatory, and anti-Alzheimer’s disease.
Yuki Ohno +4 more
doaj +1 more source
Short-term effects of α-melanocyte-stimulating hormone in three distinct melanin-pigmented cell types of Anura [PDF]
Anais da Academia Brasileira de Ciências, 2022 Ectothermic animals present melanin-containing cells in their integument and viscera. Besides cutaneous melanophores, amphibians have melanomacrophages in the hepatic parenchyma and melanocytes in the viscera, which are also present in their testicular ...
RODRIGO ZIERI +2 more
doaj +1 more source
Astrocytes: New Targets of Melanocortin 4 Receptor Actions [PDF]
, 2013 Astrocytes exert a wide variety of functions with paramount importance in brain physiology. After injury or infection, astrocytes become reactive and they respond by producing a variety of inflammatory mediators that help maintain brain homeostasis. Loss
Carniglia, Lila +4 more
core +1 more source
Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
Acta Pharmaceutica Sinica B, 2014 2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L.
Ryuji Uchida +2 more
doaj +1 more source
The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes
Cell Death Discovery, 2021 Variants in the melanocortin-1 receptor (MC1R) gene, encoding a trimeric G-protein-coupled receptor and activated by α-melanocyte-stimulating hormone (α-MSH), are frequently associated with red or blonde hair, fair skin, freckling, and skin sensitivity ...
Xin Li +6 more
doaj +1 more source
Foods, 2021 Hyperpigmentation diseases of the skin require topical treatment with depigmenting agents. We investigated the hypopigmented mechanisms of sargahydroquinoic acid (SHQA) in alpha-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 cells. SHQA reduced
Mohammed Shariful Azam +5 more
doaj +1 more source
Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]
, 2018 Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar +8 more
core +2 more sources
PLoS ONE, 2016 Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical ...
Guillaume Le Saux +5 more
doaj +1 more source