Results 191 to 200 of about 10,436 (217)

Central administration of alpha-MSH antiserum augments fever in the rabbit

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1986
alpha-Melanocyte-stimulating hormone (alpha-MSH) has a marked antipyretic action when given centrally or peripherally, and the concentration of this peptide within the septal region of the brain increases during fever. To assess the significance of endogenous central alpha-MSH in fever, antiserum was given to rabbits via a cannula implanted in the ...
S T, Shih, O, Khorram, J M, Lipton, S M, McCann   +3 more
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CSF alpha-MSH in dementia of the Alzheimer type.

Neurology, 1988
We measured CSF alpha-melanocyte stimulating hormone-like immunoreactivity (alpha-MSH-LI) in 35 patients with dementia of the Alzheimer type (DAT) and in 27 healthy control subjects. Mean alpha-MSH-LI concentration was significantly decreased in DAT patients as compared with age-matched controls.
RAINERO, Innocenzo, MAY C, KAYE JA, FRIEDLAND RP, RAPOPORT SI   +4 more
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alpha-MSH-induzierte anorexigene Signalwege in murinen Hypothalamuszellen

2013
In der deutschen Bevölkerung leidet, bezogen auf den BMI (Body-Mass-Index), etwa jeder zweite an Übergewicht. Innerhalb dieser Gruppe müssen dabei über 25 % als krankhaft adipös eingestuft werden. Trotz der weiten Verbreitung, ist zurzeit weder eine erfolgreiche medikamentöse Therapie der Adipositas verfügbar, noch sind die grundlegenden Mechanismen ...
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Synthesis of cyclic alpha-MSH peptides

1998
Cyclic lactam analogs of α-melanocyte stimulating hormone (α-MSH) have been shown to be potent agonists in the frog skin bioassay [Al-Obeidi, F. et al., J. Med. Chem., 32 (1989) 2555], demonstrating melanocortin-1 (MC1) receptor activity. We synthesized cyclic α-MSH(1-13) and α-MSH(4-10) lactam analogs.
Schaaper, W.M.M., Adan, R.A.H., Posthuma, T.A., Oosterom, J., Gispen, W.H., Meloen, R.H.   +5 more
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Is alpha-MSH deficiency the cause of Alzheimer's disease?

Medical Hypotheses, 1986
The hypothesis is that a functional deficiency of alpha-melanotropin (alpha-MSH) is the primary event in the development of Alzheimer's disease. Beginning with the concept that Alzheimer's disease occurs because of a deficiency of a neurotrophic factor specific for central cholinergic neurons data is then presented to support the hypothesis that alpha ...
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Studies on factors influencing human plasma alpha-MSH.

Anticancer research, 1990
The various physiological effects of alpha-MSH, mainly on the CNS and on pigmentation in animal models, are well documented in the literature. Only a few investigators have confirmed similar properties in the human. However, the possible physiopathological role played by this hormone in human melanoma is still poorly defined.
Ghanem, Ghanem Elias, Verstegen, John, De Rijcke, S, Hanson, P, Van Onderbergen, Anne, Libert, Anita, Del Marmol, Véronique, Arnould, Roland, Vercammen Grandjean, Alain, Lejeune, Ferdinand   +9 more
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(Radio)pharmacological characterization of novel alpha-MSH derivatives

2015
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Gao F, Sihver W, Bergmann R, HaaseKohn C, Steinbach J, Carta D, Bolzati C, Calderan A, Pietzsch J, Pietzsch HansJ   +9 more
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Molecular basis of the alpha-MSH/IL-1 antagonism.

Annals of the New York Academy of Sciences, 2000
The neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) is recognized as a potent mediator of immune and inflammatory reactions. Accordingly, alpha-MSH in vitro, as well as in vivo, antagonizes the proinflammatory activities of cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF alpha). Since the molecular basis
T, Brzoska, D H, Kalden, T, Scholzen, T A, Luger   +3 more
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[Effect of ultraviolet rays on alpha-MSH plasma concentration].

Zeitschrift fur Hautkrankheiten, 1984
Influence of Ultraviolet Rays on alpha-MSH Plasmaconcentration. Ultraviolet total-body irradiation induces changes of alpha-MSH plasmaconcentration dependent on wave-length of the source of radiation as well as skin type of the volunteers. Following UV-A total-body irradiation, we observed a significant increase of the proteohormone alpha-MSH, whereas ...
R N, Bartelt, P, Altmeyer, L, Stöhr, G N, Chilf, H, Holzmann   +4 more
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Studies of alpha-MSH-containing nerves in the brain.

Progress in biochemical pharmacology, 1981
alpha-Melanocyte stimulating hormone (alpha-MSH) immunofluorescence was observed in the rat brain using a highly specific and well-characterized antibody. alpha-MSH was contained in the arcuate nucleus cell bodies and in varicose fibers distributed throughout the brain stem. alpha-MSH-containing fibers were present in various nuclei of the hypothalamus,
T L, O'Donohue, D M, Jacobowitz
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