Results 61 to 70 of about 8,015 (172)

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Alpha-Melanocyte-Stimulating Hormone Maintains Retinal Homeostasis after Ischemia/Reperfusion

Biomolecules
Augmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes protects the retinas from degeneration. The retinal cells are protected from oxidative and apoptotic signals of death.
Tat Fong Ng, Jenna Y. Cho, John L. Zhao, John R. Gardiner, Eric S. Wang, Elman Leung, Ziqian Xu, Samantha L. Fineman, Melinda Lituchy, Amy C. Lo, Andrew W. Taylor   +10 more
doaj   +1 more source

Identification of Anti-Melanogenesis Constituents from Morus alba L. Leaves

Molecules, 2018
The individual parts of Morus alba L. including root bark, branches, leaves, and fruits are used as a cosmetic ingredient in many Asian countries. This study identified several anti-melanogenesis constituents in a 70% ethanol extract of M.
Hong Xu Li, Jung Up Park, Xiang Dong Su, Kyung Tae Kim, Jong Seong Kang, Young Ran Kim, Young Ho Kim, Seo Young Yang   +7 more
doaj   +1 more source

Neural Mechanisms of Shooting Preparation Under High‐Risk and High‐Precision Tasks: A Multiscale EEG Study

Brain and Behavior, Volume 16, Issue 3, March 2026.
This study investigated the neural mechanisms underlying the shooting preparation phase in 30 shooters across three task conditions, with concurrent collection of shooting performance metrics and self‐report measures. The findings revealed that during high‐pressure shooting tasks (Hostage‐Rescue and Long‐Range), shooters experienced significantly ...
Xinyu Shi, Xiuyan Hu, Xinzhou Chen, Aiyong Bao, Bowen Gong, Ting Shi, Yunfa Fu, Anmin Gong   +7 more
wiley   +1 more source

Glutathione Trisulphide Improves Skin Brightness with Anti-Melanogenesis Effects and Maintains Intracellular Persulphide Levels

Cosmetics
Melanin, the principal component of skin pigmentation, is produced through tyrosinase activity. Recently, supersulphides have been identified in human cells and found to play a role in maintaining cellular activities.
Yoshiaki Uchida, Toshiya Sato
doaj   +1 more source

Quercetin and Its Nano‐Based Formulations Against Skin Cancer: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments—including surgery, chemotherapy, and radiotherapy—often suffer from limitations such as adverse side effects, tumor resistance, and inadequate efficacy.
Mahtab Khanyabzadeh, Alireza Emamifar, Nikoo Emtiazi, Amir Nazari, Masoumeh Shekarriz, Amin Karami, Fateme Hashem Beik Mahallati, Rahineh Nomani Lafmejani, Atieh Dariush, Seyed Mohammad Mahdi Rohani, Elaheh Mohseni Vadeghani, Negin Khoshnood, Hamid Reza Ojaghi, Fatemeh Rezaei‐Tazangi, Reza Arefnezhad   +14 more
wiley   +1 more source

Validation of the City Birth Trauma Scale in a sample of Norwegian mothers

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 3, Page 508-518, March 2026.
The Norwegian City Birth Trauma Scale (City BiTS‐Nor) demonstrated strong psychometric properties in a sample of 1079 mothers. A bifactor structure and high reliability support its use for assessing childbirth‐related PTSD symptoms. Findings highlight its clinical utility for screening and guiding targeted interventions in perinatal mental health care.
Silje Marie Haga, Luisa Bergunde, Lara Seefeld, Susan Ayers, Malin Eberhard‐Gran, Susan Garthus‐Niegel   +5 more
wiley   +1 more source

Validity and accuracy of the Whooley questions to identify symptoms of depression in Norwegian postpartum women

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 3, Page 436-443, March 2026.
Identifying time‐efficient case‐finding instruments for postpartum depression is imperative for early detection. The results of the present study show strong psychometric properties of the two‐item Whooley instrument, making it a suitable case‐finding instrument for symptoms of depression in primary health care.
Kamilla Rognmo, Silje Haga, Susan Garthus‐Niegel, Catharina Elisabeth Arfwedson Wang, Malin Eberhard‐Gran   +4 more
wiley   +1 more source

Dialectical Behavior Therapy and Cognitive Behavior Therapy in Individuals With Binge‐Eating Disorder: What Works for Whom?

International Journal of Eating Disorders, Volume 59, Issue 3, Page 534-545, March 2026.
ABSTRACT Objective To evaluate moderators and predictors of response to cognitive behavioral therapy (CBT) and dialectical behavior therapy (DBT) for binge‐eating disorder (BED). Method Moderators/predictors of treatment outcome, central to CBT and to DBT treatment, were chosen from an aggregated dataset of two clinical outcome studies with non‐random ...
Mirjam W. Lammers, Maartje S. Vroling, Ross D. Crosby, Suzanne H. W. Mares, Giel J. M. Hutschemaekers, Tatjana Van Strien   +5 more
wiley   +1 more source