Results 31 to 40 of about 195,193 (266)

Synthesis and structure of 26 (or 27)-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24S,25 xi-pentol isolated from the urine and feces of a patient with sitosterolemia and xanthomatosis.

Journal of Lipid Research, 1985
The urine and feces of a patient with the rare inherited lipid storage disease, sitosterolemia and xanthomatosis, were analyzed. Substantial quantities of C26-bile alcohol, 26 (or 27)-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24S,25 xi-pentol along ...
B Dayal, G S Tint, V Toome, A K Batta, S Shefer, G Salen   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

AN EXPERIMENTAL INVESTIGATION OF THE 236U DETECTION LIMIT IN THE SURFACE AIR USING RADIOCHEMICAL SEPARATION AND ALPHA-SPECTROMETRY

Радиационная гигиена, 2015
Due to nuclear weapon testing, nuclear reactor accidents, uranium mining and nuclear fuel reprocessing, additional uranium has been introduced into the environment.
A. D. Gedeonov, I. V. Kolchin, A. K. Avenirov   +2 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Detectors from CdTe and CdZnTe for spectrometry gamma and alpha of radiations [PDF]

Ядерна фізика та енергетика, 2007
Results of examination of spectrometer performances CdTe (CdZnTe) detectors are submitted at recording gamma radiations in a range of 15 - 500 keV, and alpha radiations in a range of 4 - 8 MeV.
V. V. Levenets, O. P. Omelnyk, A. O. Shchur, V. M. Borysenko, V. E. Kutny, A. V. Rybka, I. N. Shlyakhov, O. O. Zakharchenko   +7 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Decreased levels of genuine large free hCG alpha in men presenting with abnormal semen analysis

Reproductive Biology and Endocrinology, 2011
Background The pregnancy hormone human chorionic gonadotropin (hCG) and its free subunits (hCG alpha, hCG beta) are produced in the male reproductive tract and found in high concentrations in seminal fluid, in particular hCG alpha.
Plas Eugen, Lindner Herbert, Gruschwitz Matthias, Gerth Regine, Zenzmaier Christoph, Berger Peter   +5 more
doaj   +1 more source

Low Background Radiation Detection Techniques and Mitigation of Radioactive Backgrounds

Frontiers in Physics, 2020
The study of rare fundamental physics phenomena, such as double-beta decay, rare nuclear decays and dark matter, requires very low levels of background radiation in order to observe a signal.
Matthias Laubenstein, Ian Lawson
doaj   +1 more source

Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans

Nature Communications, 2022
Untargeted mass spectrometry-based metabolomics can reveal new biochemistry, but data analysis is challenging. Here, the authors develop Metaboseek, an open-source software that facilitates metabolite discovery, and apply it to characterize fatty acid ...
Maximilian J. Helf, Bennett W. Fox, Alexander B. Artyukhin, Ying K. Zhang, Frank C. Schroeder   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source