Results 91 to 100 of about 3,545,087 (293)

Complexity and Performance Analysis of Supervised Machine Learning Models for Applied Technologies: An Experimental Study with Impulsive α-Stable Noise

Technologies
Impulsive alpha (α)-stable noise, characterized by heavy tails and intense outliers, is a key ingredient in simulating financial, medical, seismic, and digital communication technologies. It poses versatile challenges to conventional machine learning (ML)
Areeb Ahmed, Zoran Bosnić
doaj   +1 more source

Modelling the distribution of day-ahead electricity returns: a comparison [PDF]

This paper contributes to characterizing the probability density of the price returns in some European day-ahead electricity markets (NordPool, APX, Powernext) by fitting some flexible and general families of distributions, such as the alpha-stable ...
Sandro Sapio
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Spectral Profiling of Early αsyn Aggregation in HEK293 Cells Modified to Stably Express Human WT and A53T-αsyn

Cells
Alpha-synuclein (αsyn) misfolding and aggregation underlie several neurodegenerative disorders, including Parkinson’s disease. Early oligomeric intermediates are particularly toxic yet remain challenging to detect and characterize within cellular systems.
Priyanka Swaminathan, Karsten Sættem Godø, Eline Bærøe Bjørn, Therése Klingstedt, Debdeep Chatterjee, Per Hammarström, Rajeevkumar Raveendran Nair, Mikael Lindgren   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Wilcoxon Nonparametric CFAR Scheme for Ship Detection in SAR Image

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The parametric constant false alarm rate (CFAR) detection algorithms, which are based on various statistical distributions, such as Gaussian, Gamma, Weibull, log-normal, $G^{0}$, and alpha-stable distribution, are most widely used to detect the ship ...
Xiangwei Meng
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Habitat transformation reshapes protistan community composition and assembly processes in coastal wetlands of southeastern China

Applied and Environmental Microbiology
Coastal wetlands along southeastern China have undergone extensive habitat transformations, notably from natural mudflats (MFs) to Spartina alterniflora marshes (SAs) and aquaculture ponds (APs), yet the ecological consequences for sediment protistan ...
Anqi Wang, Ping Yang, Guiping Ye, Chuan Tong, Luyuan Sun, Mengmeng Feng, Zi-Yang He, Ji-Zheng He, Yongxin Lin   +8 more
doaj   +1 more source