Results 111 to 120 of about 3,545,087 (293)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Skewed alpha-stable distributions for modelling textures

, 2002
In this letter, we introduce a novel family of texture models which provide alternatives to texture models which are based on Gaussian distributions. In particular, we introduce linear textures generated with a member of the a-stable distribution family which is a generalisation of the Gaussian distribution.
Kuruoglu E.E., Zerubia J.
openaire   +1 more source

Strictly operator-stable distributions

Strictly operator-stable distributions are defined and discussed. Characterization of strictly stable distributions with exponent 1 is generalized to strictly ([alpha], Q)-stable distributions with [alpha] being an eigenvalue of Q.infinite divisibility ...
Sato, Ken-iti
core  

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Bayesian and fuzzy hybrid standard setting for pass-fail decisions in clinical examinations

BMC Medical Education
Background Pass-fail decisions in clinical examinations must be defensible, yet traditional standard-setting approaches often report a single cut score without explicitly quantifying uncertainty-an issue amplified in small cohorts and mixed-format ...
Yogeesh N., Mohammed Almakki, Asokan Vasudevan, Shiney John, Mayibongwe Tafara Mudzengi   +4 more
doaj   +1 more source

A SAS Approach for Estimating the Parameters of an Alpha-stable Distribution

Procedia Economics and Finance, 2014
AbstractAlthough there are several software products dealing with the issue of simulating and estimating a stable distribution, SAS has no procedure for stable distributions. In this paper we propose two macros for estimating the parameters of a stable distribution using McCulloch method and Kogon-Williams method; further developments are required for ...
openaire   +1 more source

Modelling microarray gene expression using alpha-stable distributions

, 2006
After normalization, the distribution of gene expressions for very different organisms have a similar shape, they usually exhibit heavier tails than a Gaussian distribution and a certain degree of asymmetry. Therefore, this distribution has been modelled
Kuruoglu E E, Ruiz D P, SalasGonzales D
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Comparative microbiological, chemical, and radiological assessment of the sacred spring and immersion pool at the Pergamene Asklepieion

Open Chemistry
Water sources associated with ancient healing centres were historically believed to possess therapeutic properties, yet their physicochemical, microbiological, and radiological characteristics remain insufficiently documented.
Yusan Sabriye, Aytas Sule, Daniskan Asli Sahiner, Ozdemir Guven, Duman Gozde, Tozan Murat, Nalbantsoy Ayse   +6 more
doaj   +1 more source