Results 131 to 140 of about 1,144,970 (369)
eLife, 2019 Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson’s disease (PD). Previously, we reported the structure of alpha-synuclein fibrils (residues 1–121), composed of two protofibrils that
R. Guerrero-Ferreira +15 more
semanticscholar +1 more source
Environmental Exposures and Parkinson's Disease. [PDF]
, 2016 Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown,
Litvan, Irene, Nandipati, Sirisha
core +2 more sources
Spreading of alpha‐synuclein – relevant or epiphenomenon? [PDF]
Journal of Neurochemistry, 2019 AbstractThe intracellular accumulation of misfolded alpha‐synuclein pathology, termed Lewy pathology, throughout the brain is a phenomenon central to Parkinson’s disease pathogenesis. In recent years it has become apparent that Lewy pathology can spread from neuron‐to‐neuron and between interconnected brain regions. Understanding the phenomenon of Lewy
Bryan A. Killinger, Jeffrey H. Kordower
openaire +2 more sources
Advanced Materials, EarlyView.This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba +20 more
wiley +1 more source
Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics. [PDF]
PLoS ONE, 2014 Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies, a pathological hallmark comprised mostly of aggregated alpha synuclein.
Hemi Dimant +5 more
doaj +1 more source
Acta Neuropathologica, 2019 The conversion of endogenous alpha-synuclein (asyn) to pathological asyn-enriched aggregates is a hallmark of Parkinson’s disease (PD). These inclusions can be detected in the central and enteric nervous system (ENS).
Nathalie Van Den Berge +11 more
semanticscholar +1 more source
Definitions, 2020 Alpha-synuclein is encoded by the human SNCA gene. This protein plays a role in the modulation of presynaptic vesicle transport and release.
semanticscholar +1 more source
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. [PDF]
, 2018 SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson's disease (PD ...
Deng, Yong-Ning +6 more
core +1 more source
Alpha-synuclein and transgenic mouse models
Neurobiology of Disease, 2004 Identified as the cause of some familial forms of Parkinson disease (PD) and as one of the major component of Lewy bodies, alpha-synuclein (alpha-syn) became the molecular hallmark of several neurodegenerative conditions now designated as synucleinopathies.
Marie-Françoise Chesselet +1 more
openaire +4 more sources
Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives
Advanced Photonics Research, EarlyView.Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka +5 more
wiley +1 more source