Results 201 to 210 of about 31,365 (260)

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

Alpha-Synuclein Lesions in the Peripheral Nervous System of the Larynx in Parkinson's Disease. [PDF]

Dysphagia
Mu L, Chen J, Nyirenda T, Li J, Hegland KW, Adler CH, Caviness JN, Shill HA, Serrano GE, Beach TG, Arizona Parkinson’s Disease Consortium.   +10 more
europepmc   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, Volume 1, Issue 1, 26 March 2026.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

Expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit Parkinson's disease-related phenotypes in a novel humanized rat model. [PDF]

PLoS One
Polinski NK, Puoliväli J, Rauhala L, Stenius TK, Bragge T, Parkkari T, Penttinen AM, Chen Y, Mabrouk OS, Glajch KE, Hirst WD, Perkinton M, Martinez TN, Frasier MA.   +13 more
europepmc   +1 more source

Methylglyoxal Affects Dopamine Homeostasis in SH‐SY5Y Cells Through the Modulation of miR‐190a and miR‐214

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
In SH‐SY5Y cells, Methylglyoxal (MGO) reduces the intracellular dopamine content, up‐regulating the expression of proteins that modulate dopamine amount (MAO‐B, COMT, and α‐Syn). The MGO‐induced increase of COMT and α‐Syn expression is mediated by the reduction of miR‐214 and miR‐190a levels.
Alessandra Croce, Paola Mirra, Francesca Chiara Pignalosa, Federica Zatterale, Immacolata Prevenzano, Domenico Conza, Luca Ulianich, Claudia Miele, Francesco Beguinot, Francesca Fiory   +9 more
wiley   +1 more source

Imaging alpha-synuclein pathology in Parkinson's disease. [PDF]

Neural Regen Res
Ni R.
europepmc   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source