Results 201 to 210 of about 1,144,970 (369)
Method Overview for Discovering ATE1 Substrates and their Arginylation Sites
ChemBioChem, EarlyView.Arginylation is a decades‐old post‐translational modification but is inherently difficult to study. A plurality of methods have been developed and deployed to uncover the biology and substrates of this modification. This review covers the history, major advancements, and substrates discovered over the course of six decades.
Richard M. Searfoss +2 more
wiley +1 more source
Glutathione (GSH) conjugates with dopamine (DA)-derived quinones to form reactive or non-reactive GSH-conjugates [PDF]
, 2009 In this study we demonstrate for the first time that GSH could rapidly conjugate with dopamine (DA)-derived DA-o-quinones without enzymatic catalysis to form short-lived intermediate GSH-conjugates (2-S-GSH-DA-o-quinone and 5-S-GSH-DA-o-quinone).
Tit Meng Lim, Zhidong Zhou
core +1 more source
The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure
Chronic Diseases and Translational Medicine, EarlyView.The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao +7 more
wiley +1 more source
Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid
ChemistryEurope, EarlyView.Amyloid‐selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments.
Atsushi Iwai +11 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.4‐dimethylamino‐1,8‐naphthalimide (NMI) as new fluorescence‐responsive tool for HO• detection. Proof of concept illustrating that NMI selectively probes HO• produced by Cu‐bound to Aβ16 in presence of scavengers with an amplified response. Abstract Overproduction of reactive oxygen species (ROS) is involved in several diseases.
Yelisetty Venkata Suseela +4 more
wiley +1 more source
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain [PDF]
, 2007 Andisheh Eslamboli +8 more
openalex +1 more source
Unveiling the Potential of a New β‐Cyclodextrin‐Suxibuzone Conjugate in Proteasome Regulation
ChemMedChem, EarlyView.A novel β‐cyclodextrin‐suxibuzone conjugate enhances chymotryptic‐like activity of the 20S proteasome in a dose‐dependent manner. It remains stable and is internalized in SH‐SY5Y cells for 24 h. These findings suggest therapeutic potential for proteasome‐related disorders through targeted proteasome activation.
Noemi Bognanni +6 more
wiley +1 more source
25. The Role of Alpha-Synuclein (α-syn) Phosphorylation at Ser-129 on the Development of Parkinson-Like Neurodegeneration [PDF]
, 2007 openalex +1 more source
Chemistry–Methods, EarlyView.Cerebrospinal fluid (CSF) is an important diagnostic matrix in neurology. This review illustrates the potentials and pitfalls of current CSF analysis by nuclear magnetic resonance. Created with BioRender.com in BioRender. Berezhnoy, G. (2025) https://BioRender.com/x80l903. Web of Science is owned by Clarivate.
Georgy Berezhnoy +4 more
wiley +1 more source