Results 291 to 300 of about 68,100 (329)

Alpha-Synuclein as a Potential Biomarker for Inclusion Body Myositis in Blood and Muscle. [PDF]

Neuropathol Appl Neurobiol
Mayer T, Scholle L, Foerster L, Schneider I, Stoltenburg-Didinger G, Delank KS, Kendzierski T, Koelsch A, Kleeberg K, Kraya T, Barba L, Naegel S, Schänzer A, Otto M, Mensch A.   +14 more
europepmc   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features. [PDF]

Mol Neurodegener
Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstetter M, Fernández-Busnadiego R, Zimprich A, Outeiro TF.   +19 more
europepmc   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Experimental Ischemic Stroke-Induced Alpha-Synuclein Pathology Enhances Endothelial Inflammatory Response and Impairs Angiogenesis. [PDF]

Stroke
Bogale TA, Mercurio D, Valente A, Seminara S, Faustini G, Longhena F, Bianchi A, Mitola S, Bellucci A, Fumagalli S, Pizzi M.   +10 more
europepmc   +1 more source

Correction: MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation. [PDF]

Sci Rep
Kline EM, Jernigan JE, Scharer CD, Maurer J, Hicks SL, Herrick MK, Wallings RL, Kelly SD, Chang J, Menees KB, Manfredsson FP, McFarland NR, Boss JM, Tansey MG, Joers V.   +14 more
europepmc   +1 more source

Role of alpha-synuclein in the regulation of dopamine neurotransmission in the striatum [PDF]

Chadchankar, Heramb
core  

C-terminus-dependent detection of lysosomal alpha-synuclein in nigral Parkinson's disease human brain neurons. [PDF]

Mol Neurodegener
Morella ML, Al Khayrat B, Moors TE, In't Veld L, Frigerio I, Udayar V, van der Gaag BL, van de Berg WDJ.   +7 more
europepmc   +1 more source

THE EFFECTS OF DIFFERENT SONICATION METHODS ON ALPHA-SYNUCLEIN PRE-FORMED FIBRILS

Hilal Akyel, Elham Bahador Zırh, Selim Zırh, Banu Cahide Tel   +3 more
openalex   +1 more source

Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1. [PDF]

Cell Rep
Cabaj M, Mazzara PG, Gaertner ZA, Wang R, Pauers MM, Randolph LK, Roque CG, Feeney S, Raimo S, de Prisco N, Chemiakine A, Wang X, Singh RK, Rajasekaran S, Yalamanchili HK, Miles W, Baldwin K, Zhang C, Harms MB, Khurana V, Brandt V, Hengst U, Awatramani R, Gennarino VA.   +23 more
europepmc   +1 more source