Results 271 to 280 of about 659,948 (302)
Some of the next articles are maybe not open access.
2022
In synucleinopathies alpha-synuclein (αsyn) aggregates and spreads in the brain in a prion-like manner, affecting different cells and brain regions depending on the disease ; resulting in distinct histopathological and clinical features. However the mechanisms underlying the selective vulnerability and tropism for different cell populations remain ...
Rey, Nolwen +4 more
openaire +2 more sources
In synucleinopathies alpha-synuclein (αsyn) aggregates and spreads in the brain in a prion-like manner, affecting different cells and brain regions depending on the disease ; resulting in distinct histopathological and clinical features. However the mechanisms underlying the selective vulnerability and tropism for different cell populations remain ...
Rey, Nolwen +4 more
openaire +2 more sources
Neurobiology of alpha-synuclein.
Molecular neurobiology, 2004Alpha-synuclein is an abundant neuronal protein that has been linked both to normal synaptic function and to neurodegeneration. Most significantly, mutations in the gene encoding for alpha-synuclein are responsible for Parkinson's disease (PD) in rare familial cases, and the aggregated protein is a major component of Lewy bodies found in sporadic PD ...
Kostas, Vekrellis +2 more
openaire +1 more source
Deamidation of alpha-synuclein.
Protein science : a publication of the Protein Society, 2009The rates of deamidation of alpha-synuclein and single Asn residues in 13 Asn-sequence mutants have been measured for 5 x 10(-5)M protein in both the absence and presence of 10(-2)M sodium dodecyl sulfate (SDS). In the course of these experiments, 370 quantitative protein deamidation measurements were performed and 37 deamidation rates were determined ...
Noah E, Robinson +4 more
openaire +1 more source
The Role of Alpha-Synuclein in Neurodevelopmental Diseases
Molecular NeurobiologyNeurodevelopmental disorders are a group of diseases with cognitive, motor, and emotional development deficits. Alpha-synuclein (α-syn) is a synaptic protein involved in transmission and neurodevelopment. This protein was previously shown to be associated with several disorders, including Parkinson's disease.
Sanaz Bordbar +5 more
openaire +2 more sources
Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue
Brain, 2022Tilo Kunath +2 more
exaly
Advances in understanding the function of alpha-synuclein: implications for Parkinson’s disease
Brain, 2023Paolo Calabresi +2 more
exaly
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats
Brain, 2021Nathalie Van Den Berge +2 more
exaly