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International Journal of Biological Macromolecules, 2017
Expression of human alpha-synuclein in E. coli cells is known to result in a mixture of the wild type alpha-synuclein and the protein containing Tyr136Cys substitution due to the translational error. The amount of Cys136 alpha-synuclein (Cys136-AS) may reach approximately 50% of the recombinant protein.
K V Barinova +2 more
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Expression of human alpha-synuclein in E. coli cells is known to result in a mixture of the wild type alpha-synuclein and the protein containing Tyr136Cys substitution due to the translational error. The amount of Cys136 alpha-synuclein (Cys136-AS) may reach approximately 50% of the recombinant protein.
K V Barinova +2 more
exaly +3 more sources
Alpha-synuclein and Parkinson's disease
Cellular and Molecular Life Sciences, 2000The involvement of alpha-synuclein in neurodegenerative diseases was first suspected after the isolation of an alpha-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD). Later, two different alpha-synuclein mutations were shown to be associated with autosomal-dominant Parkinson's disease (PD), but only in a small number of ...
C B, Lücking, A, Brice
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Alpha-synuclein and Parkinson's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004Alpha-synuclein (alpha-syn) is a small soluble protein expressed primarily at presynaptic terminals in the central nervous system. Interest in alpha-syn has increased dramatically after the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's disease (PD). The physiological functions of alpha-
RECCHIA, ALESSANDRA +5 more
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Ubiquitination of alpha-synuclein.
Biochemistry, 2005Filamentous alpha-synuclein depositions are the defining hallmarks of a subset of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. We previously reported that alpha-synuclein in those brains are extensively phosphorylated at Ser129 [Fujiwara et al. (2002) Nat. Cell Biol.
Takashi, Nonaka +2 more
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Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity
Molecular Biology Reports, 2009Alpha-synuclein aggregation and cytotoxicity are widely considered to play a critical role in the process of Parkinson's disease. Heat shock proteins are a large family of cellular protective molecules in most kinds of cells. In this study, we examined the impact of dominant-positive heat shock transcription factor 1 (HSF1) on alpha-synuclein over ...
Xu, Liangliang +5 more
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Toward imaging of alpha-synuclein with PET
Cell, 2023Development of radiopharmaceuticals for in vivo positron emission tomography imaging of alpha-synuclein aggregates has the potential to revolutionize Lewy body disease diagnosis and treatment. Reporting in this issue of Cell, Xiang et al. developed a high-affinity positron emission tomography tracer for alpha-synuclein.
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Alpha-synuclein and neurodegenerative diseases
Nature Reviews Neuroscience, 2001In recent years, two developments have imparted a new direction to research on the aetiology and pathogenesis of Parkinson's disease. First, the discovery that a missense mutation in the α-synuclein gene is a rare genetic cause of Parkinson's disease.
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Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.
Glycobiology, 2006Recent studies have begun to investigate the role of agrin in brain and suggest that agrin's function likely extends beyond that of a synaptogenic protein. Particularly, it has been shown that agrin is associated with the pathological lesions of Alzheimer's disease (AD) and may contribute to the formation of beta-amyloid (Abeta) plaques in AD.
I-Hsuan, Liu +5 more
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2022
Parkinson disease is an age-related disorder. It was seen all part of society. It is existed by genetic predisposition and different effects. The disease usually starts insidously and its symptoms progress slow but causing acceleration. Middle brain gets narrow according to normal brain in Parkinson, pigmentation is decreased in substantia nigra pars ...
Başaran, A., Bayram, B., Ak, A.
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Parkinson disease is an age-related disorder. It was seen all part of society. It is existed by genetic predisposition and different effects. The disease usually starts insidously and its symptoms progress slow but causing acceleration. Middle brain gets narrow according to normal brain in Parkinson, pigmentation is decreased in substantia nigra pars ...
Başaran, A., Bayram, B., Ak, A.
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Release and uptake of pathologic alpha-synuclein
Cell and Tissue Research, 2018Parkinson's disease (PD) is a chronic progressive neurodegenerative disease, which is characterized by severe loss of dopaminergic neurons and formation of Lewy bodies, which are rich in aggregated alpha-synuclein (α-syn). Two decades of intensive research have compiled a massive body of evidence that aggregation of α-syn is a critical process in PD ...
Veselin, Grozdanov, Karin M, Danzer
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