Results 241 to 250 of about 61,554 (301)

The extent of alpha-synuclein aggregate accumulation in neurons varies depending on the type of neurotransmitter they release. [PDF]

Sci Rep
Kameda H, Okamoto S, Ogasawara K, Okuzumi A, Hattori N, Hioki H, Koike M.   +6 more
europepmc   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Alpha-synuclein seeding activity in postmortem tissues from patients with diffuse and isolated Lewy bodies. [PDF]

Acta Neuropathol Commun
Baranová S, Matěj R, Soukup J, Dušek P, Holada K.   +4 more
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles

Braun T, Tiberi C, Reber V, Ghosh D, Riek R, Serdiuk T.   +5 more
europepmc   +1 more source

Evaluation of an antibody panel for alpha-synuclein detection in FFPE rectal biopsies in Parkinson's disease. [PDF]

IBRO Neurosci Rep
Schröder K, Kintrup C, Kulcsárová K, Heinzel S, Kluge A, Wedel T, Böttner M, Lucius R, Pendziwiat M, Schoch S, Ellrichmann M, Berg D, Schaeffer E, Cossais F.   +13 more
europepmc   +1 more source

A Cross‐Disease Microglial Transcriptional Program Characterizes Neurodegeneration and Highlights SPP1 as a Biomarker

Glia, Volume 74, Issue 6, June 2026.
Distinct microglial subpopulations are depicted, highlighting variations in gene expression and functional roles in response to specific disease conditions and the complexity of microglial activation and differentiation in neurodegeneration. ABSTRACT Microglial cells are key players in maintaining brain homeostasis and responding to pathological ...
Alessandro Palma, Roberta Stefanelli, Francesco Trenta, Chiara Projetti, Greta Massa, Sonia Canterini, Maria Teresa Fiorenza   +6 more
wiley   +1 more source

Elevated plasma levels of alpha-synuclein are dispensable for Parkinson's disease pathology. [PDF]

NPJ Parkinsons Dis
Jeong JY, Kim N, Li Y, Kim DJ, Kim HK, Oh WJ.   +5 more
europepmc   +1 more source