Results 231 to 240 of about 659,948 (302)

Sex-Dependent Dynamics of Behavioural and Neuropathological Changes in an A53T Alpha-Synuclein Mouse Model of Parkinson's Disease. [PDF]

Cell Mol Neurobiol
Zubelzu M, Bidgood R, Murueta-Goyena A, Ruiz-Ortega JÁ, Lafuente JV, Morera-Herreras T.   +5 more
europepmc   +1 more source

Brain pathology in relation to somatic diseases: Exploring the body–brain crosstalk

Journal of Internal Medicine, EarlyView.
Abstract Several somatic diseases have been consistently linked with an increased dementia risk. However, the underlying neuropathological substrates remain poorly characterized. This narrative review aims to summarize evidence on the association between common age‐related somatic conditions (i.e., heart diseases, type 2 diabetes, kidney disease, liver
G. Grande, M. Valletta, F. Gasparini, D. L. Vetrano, M. Canevelli, J. R. Bacci, C. Qiu, A. Marengoni, M. Toccaceli Blasi, H. Xu, L. Fratiglioni, M. M. Mielke   +11 more
wiley   +1 more source

The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder. [PDF]

Biomark Med
Marcotte S, Levine T, Freeman R, Gibbons CH.   +3 more
europepmc   +1 more source

Impact of N-terminal acetylation on Cu(I) coordination by alpha synuclein protein. [PDF]

J Inorg Biochem
Arcos-López T, Lim H, Hedman B, Hodgson KO, Vela A, Fernández-Outón CO, Solomon EI, Quintanar L.   +7 more
europepmc   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

Association of Prodromal Parkinson's Disease‐Like Features in Long COVID With Dream‐Enactment Behaviours

Journal of Sleep Research, EarlyView.
ABSTRACT Emerging evidence links COVID‐19 to the predisposition of Parkinson's disease (PD). However, the relationship between long COVID and prodromal PD‐like features remains unclear, particularly in long COVID participants with dream‐enactment behaviours (DEBs) that may be suggestive of possible REM sleep behaviour disorder.
Siyi Gong, Yaping Liu, Bei Huang, Ngan Yin Chan, Eemil Partinen, Christian Benedict, Bjørn Bjorvatn, Ilona Merikanto, Luigi De Gennaro, Yves Dauvilliers, Brigitte Holzinger, Juliana Yordanova, Maria Korman, Cátia Reis, Anne‐Marie Landtblom, Sergio Mota‐Rolim, Michael R. Nadorff, Frances Chung, Yuichi Inoue, Harald Hrubos‐Strøm, Kentaro Matsui, Courtney J. Bolstad, Pei Xue, Colin A. Espie, Charles M. Morin, Thomas Penzel, Giuseppe Plazzi, Markku Partinen, Yun Kwok Wing   +28 more
wiley   +1 more source

Disturbing dreams and dementia incidence across diverse cohort studies: A COSMIC collaboration study

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Distressing dreams were previously reported to predict future all‐cause dementia among predominantly white US participants aged 79–89 years, particularly in men. We investigated whether disturbing dreams (nightmares and bad dreams) were associated with all‐cause and Alzheimer dementia (AD) among individuals aged 60–89 years from diverse ...
Darren M. Lipnicki, Ashleigh S. Vella, Erico Castro‐Costa, Sergio Luis Blay, Maria Fernanda Lima‐Costa, Karen Ritchie, Elena Rolandi, Annalisa Davin, Michele Rossi, Ki Woong Kim, Ji Won Han, Dae Jong Oh, Ding Ding, Qianhua Zhao, Xiaowen Zhou, Yen‐Ching Chen, Jen‐Hau Chen, Perminder S. Sachdev, for Cohort Studies of Memory in an International Consortium (COSMIC)   +18 more
wiley   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, EarlyView.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source