Results 231 to 240 of about 61,554 (301)

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses. [PDF]

NPJ Parkinsons Dis
Vasili E, König A, Al-Azzani M, Bosbach C, Gatzemeier LM, Thom S, Chegão A, Vicente Miranda H, Steinem C, Erskine D, Outeiro TF.   +10 more
europepmc   +1 more source

Synphilin-1 modulates alpha-synuclein assembly, release and uptake. [PDF]

NPJ Parkinsons Dis
Lázaro DF, Amen T, Gerhardt E, Song C, Burns R, Kruse N, Santos PI, Milovanovic D, Höglinger G, Mollenhauer B, Luk KC, Lee VM, Outeiro TF.   +12 more
europepmc   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

Interaction between alpha-synuclein and tau pathologies in a mouse model of Lewy body dementia [PDF]

Jiang, Hong
core  

Disturbing dreams and dementia incidence across diverse cohort studies: A COSMIC collaboration study

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Distressing dreams were previously reported to predict future all‐cause dementia among predominantly white US participants aged 79–89 years, particularly in men. We investigated whether disturbing dreams (nightmares and bad dreams) were associated with all‐cause and Alzheimer dementia (AD) among individuals aged 60–89 years from diverse ...
Darren M. Lipnicki, Ashleigh S. Vella, Erico Castro‐Costa, Sergio Luis Blay, Maria Fernanda Lima‐Costa, Karen Ritchie, Elena Rolandi, Annalisa Davin, Michele Rossi, Ki Woong Kim, Ji Won Han, Dae Jong Oh, Ding Ding, Qianhua Zhao, Xiaowen Zhou, Yen‐Ching Chen, Jen‐Hau Chen, Perminder S. Sachdev, for Cohort Studies of Memory in an International Consortium (COSMIC)   +18 more
wiley   +1 more source