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Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology in a Parkinson's disease mouse model. [PDF]
Lee E +10 more
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Enteric glia, neuropeptides, and Parkinson's: impacts of calcitonin gene-related peptide on gut alpha synuclein. [PDF]
Templeton HN +3 more
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Cholesterol modulates vesicle clustering mediated by alpha-synuclein in a nonlinear fashion. [PDF]
Tyoe O, Aryal C, Diao J.
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Interaction of alpha-synuclein with lipids
2022Alpha-synuclein (α-syn) is a natively unfolded protein that is abundantly expressed in the central nervous system. Although it has been shown to be involved in neurotransmission and cognition, its exact functions remain elusive. The misfolding of this protein into β-sheet-rich amyloid structures and subsequent aggregation has been associated with ...
Neha, Kachappilly +3 more
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Prion Properties of Alpha-Synuclein
Molecular Biology, 2019The prion properties of alpha-synuclein, a key aggregating protein involved in the pathogenesis of so-called synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies, multiple system atrophy, and its various conformers are discussed.
A L, Schwarzman +3 more
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