Results 331 to 340 of about 1,144,970 (369)

Alpha-Synuclein Seed Amplification Assays in Parkinson's Disease: A Systematic Review and Network Meta-Analysis. [PDF]

Clin Pract
Rissardo JP, Fornari Caprara AL.
europepmc   +1 more source

Protein tandem repeats that produce frameshifts can generate new structural states and functions

The FEBS Journal, EarlyView.
We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli, Gudrun Aldrian, Jeremy Leclercq, Theo Falgarone, Santiago M. Gómez Bergna, Denis N. Prada Gori, Andrew V. Oleinikov, Ilham Shahmuradov, Andrey V. Kajava   +8 more
wiley   +1 more source

c-Abl Inhibitors in Parkinson's: Exploring Hypotheses on Alpha-Synuclein Modulation. [PDF]

Adv Pharm Bull
Nargish J, Baishya HJ, Sola P.
europepmc   +1 more source

Sleep in neurodegenerative diseases: A focus on melatonin, melanin‐concentrating hormone and orexin

Journal of Neuroendocrinology, EarlyView.
Abstract Sleep and circadian rest‐activity rhythm alterations are recognised as inherent clinical features of various neurodegenerative diseases. Traditionally viewed as secondary manifestations of neurodegeneration, recent studies have revealed that disruptions in circadian rhythm and sleep–wake cycles can precede clinical symptoms and significantly ...
Simon J. Guillot, Pierre‐Hervé Luppi, Luc Dupuis, Matei Bolborea   +3 more
wiley   +1 more source

Differential cued recall memory impairment in mild cognitive impairment due to Alzheimer's disease versus Parkinson's disease

Journal of Neuropsychology, EarlyView.
Abstract Both Alzheimer's (AD) and Parkinson's disease (PD) are often associated with memory dysfunction, but their pathophysiological underpinnings differ. The current research aimed to differentiate specific profiles of memory impairment due to AD versus PD.
Ondrej Bezdicek, Jiří Motýl, Tomáš Nikolai, Adéla Fendrych Mazancová, Jakub Hort, Robert Jech, Martin Vyhnálek, Hana Horáková   +7 more
wiley   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology. [PDF]

Neurotherapeutics
Sehlin D, Roshanbin S, Zachrisson O, Ingelsson M, Syvänen S.   +4 more
europepmc   +1 more source

MRI‐based surrogates of brain clearance in narcolepsy type 1

Journal of Sleep Research, EarlyView.
Summary Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy.
Eva M. van Heese, Jari K. Gool, Gert Jan Lammers, Ysbrand D. van der Werf, Matthias J. P. van Osch, Rolf Fronczek, Lydiane Hirschler   +6 more
wiley   +1 more source

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation. [PDF]

NPJ Parkinsons Dis
Mahul-Mellier AL, Altay MF, Maharjan N, Ait-Bouziad N, Chiki A, Jagannath S, Limorenko G, Novello S, Ricci J, Jasiqi Y, Vingill S, Wade-Martins R, Holton J, Strand C, Haikal C, Li JY, Hamelin R, Croisier M, Knott G, Mairet-Coello G, Weerens L, Michel A, Downey P, Citron M, Lashuel HA.   +24 more
europepmc   +1 more source

Evidence demands action: An invitation to share the burden of proof

Epilepsia, EarlyView.
Danielle M. Andrade, Anne T. Berg, Arunan Selvarajah, Andrea Sabo, Carolina Gorodetsky, Paula Marques, Ilakkiah Chandran, Miles Thompson, Quratulain Zulfiqar Ali, Mary Pat McAndrews, Maria Carmela Tartaglia, Victor S. T. Lira, Linda Huh, Mary Connolly, Arezoo Rezazadeh, Farah Qaiser, Tadeu A. Fantaneanu, Monica Duong, Karen Barboza, Lysa Boissé Lomax, Luciana Inuzuka Nakaharada, Jack Arbinuch, Mariana Espindola, Eliana Garzon, Gianluca Sorrento, Mary Anne Meskis, Nicole Villas, Veronica Hood, Marta Gonzalez, Elena Cardenal‐Muñoz, Jose Angel Aibar, Lauraine McKenna, Christine Linehan, Ryan Yuen, Babak Taati, Alfonso Fasano, Orrin Devinsky, Kette Valente   +37 more
wiley   +1 more source