Results 351 to 360 of about 1,144,970 (369)

High Agreement Across Laboratories Between Different Alpha-Synuclein Seed Amplification Protocols. [PDF]

Eur J Neurol
Bräuer S, Weber M, Deuschle C, Julia K, Concha-Marambio L, Bernhardt AM, Kadam V, Mengel D, Ruf WP, Kassubek J, Schniewind I, Kuhs S, Rossi M, Parchi P, Levin J, Danzer KM, Synofzik M, Brockmann K, Falkenburger BH.   +18 more
europepmc   +1 more source

Mechanisms of Alpha-Synuclein-Seeded Aggregation in Neurons Revealed by Fluorescence Lifetime Imaging. [PDF]

ACS Chem Neurosci
Ivey PE, Guzman Sosa M, Salem A, Min S, Qi W, Scott AN, Ejendal KFK, Kinzer-Ursem TL, Rochet JC, Webb KJ.   +9 more
europepmc   +1 more source

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Interaction of alpha-synuclein with lipids

2022
Alpha-synuclein (α-syn) is a natively unfolded protein that is abundantly expressed in the central nervous system. Although it has been shown to be involved in neurotransmission and cognition, its exact functions remain elusive. The misfolding of this protein into β-sheet-rich amyloid structures and subsequent aggregation has been associated with ...
Neha, Kachappilly, Jyotirmay, Srivastava, Bani Prasad, Swain, Poonam, Thakur   +3 more
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Alpha-synuclein and Parkinson's disease

Cellular and Molecular Life Sciences, 2000
The involvement of alpha-synuclein in neurodegenerative diseases was first suspected after the isolation of an alpha-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD). Later, two different alpha-synuclein mutations were shown to be associated with autosomal-dominant Parkinson's disease (PD), but only in a small number of ...
Alexis Brice, C. B. Lücking
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Dimerization of Tyr136Cys alpha-synuclein prevents amyloid transformation of wild type alpha-synuclein

International Journal of Biological Macromolecules, 2017
Expression of human alpha-synuclein in E. coli cells is known to result in a mixture of the wild type alpha-synuclein and the protein containing Tyr136Cys substitution due to the translational error. The amount of Cys136 alpha-synuclein (Cys136-AS) may reach approximately 50% of the recombinant protein.
Elena V. Schmalhausen, M.L. Kuravsky, Marina V. Serebryakova, Vladimir I. Muronetz, Alexander M. Arutyunyan, K.V. Barinova   +5 more
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Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity

Molecular Biology Reports, 2009
Alpha-synuclein aggregation and cytotoxicity are widely considered to play a critical role in the process of Parkinson's disease. Heat shock proteins are a large family of cellular protective molecules in most kinds of cells. In this study, we examined the impact of dominant-positive heat shock transcription factor 1 (HSF1) on alpha-synuclein over ...
Gong Shoufang, Hou Yonghui, Xu Liangliang, Xu Liangliang, Zou Jiangying, E. Shunmei, Zhou Wei   +6 more
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Alpha-synuclein and neurodegenerative diseases

Nature Reviews Neuroscience, 2001
In recent years, two developments have imparted a new direction to research on the aetiology and pathogenesis of Parkinson's disease. First, the discovery that a missense mutation in the α-synuclein gene is a rare genetic cause of Parkinson's disease.
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