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Release and uptake of pathologic alpha-synuclein
Cell and Tissue Research, 2018Parkinson's disease (PD) is a chronic progressive neurodegenerative disease, which is characterized by severe loss of dopaminergic neurons and formation of Lewy bodies, which are rich in aggregated alpha-synuclein (α-syn). Two decades of intensive research have compiled a massive body of evidence that aggregation of α-syn is a critical process in PD ...
Karin M Danzer, Veselin Grozdanov
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2022
In synucleinopathies alpha-synuclein (αsyn) aggregates and spreads in the brain in a prion-like manner, affecting different cells and brain regions depending on the disease ; resulting in distinct histopathological and clinical features. However the mechanisms underlying the selective vulnerability and tropism for different cell populations remain ...
Rey, Nolwen +4 more
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In synucleinopathies alpha-synuclein (αsyn) aggregates and spreads in the brain in a prion-like manner, affecting different cells and brain regions depending on the disease ; resulting in distinct histopathological and clinical features. However the mechanisms underlying the selective vulnerability and tropism for different cell populations remain ...
Rey, Nolwen +4 more
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Alpha Synuclein and Parkinson’s Disease
2018α-Synuclein predominantly expressed in the brain is a small acidic protein containing three domains namely N-terminal lipid-binding α-helix, amyloid-binding central domain (NAC), and C-terminal acidic tail. The physiological functions of this protein remain poorly understood.
Isha Solanki +3 more
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Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease
Neurobiology of Disease, 2018E. Rocha, B. Miranda, L. Sanders
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Peptides as modulators of alpha-synuclein aggregation
2015?-Synuclein forms amyloid deposits in the dopaminergic neurons; a process that is believed to contribute to the Parkinson's disease. An emerging theme in amyloid research is the hypothesis that the toxic species produced during amyloid formation share common physic-chemical features and exert their effects by common modes.
Ruzza Paolo +8 more
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Oligomerisation and toxicity of alpha-synuclein [PDF]
Biochemical Society Transactions, 2002 openaire +1 more source