Results 51 to 60 of about 1,304,324 (179)

Prevalence of Alpha(α)-Thalassemia in Southeast Asia (2010–2020): A Meta-Analysis Involving 83,674 Subjects

International Journal of Environmental Research and Public Health, 2020
Alpha(α)-thalassemia is a blood disorder caused by many types of inheritable α-globin gene mutations which causes no-to-severe clinical symptoms, such as Hb Bart’s hydrops fetalis that leads to early foetal death. Therefore, the aim of this meta-analysis
L. P. W. Goh, E. Chong, Ping-Chin Lee
semanticscholar   +1 more source

An Integrated Genotyping Strategy for α/β‐Thalassemia: Based on the Analysis of the Coding Sequences and Expression Levels of HBA2, HBA1, and HBB in Peripheral Blood mRNA

Journal of Clinical Laboratory Analysis, EarlyView.
We have developed an integrated mRNA‐based strategy for thalassemia genotyping. Its characteristics included using only three Sanger sequencing reactions to analyze the full‐length coding sequence of HBA2, HBA1 and HBB, and employing a new multiple quantitative fluorescence PCR to simply assess and present the impact of common mutations on the ...
Hongjian Chen, Qi Yao, Mianai Fu
wiley   +1 more source

Heterozygous Beta‐Thalassaemia in Pregnancy: Two Rare Causes of Severe Fetal Anemia Requiring Intrauterine Blood Transfusions

Prenatal Diagnosis, EarlyView.
ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij, Frans J. W. Smiers, Tamara T. Koopmann, Ingrid Krapels, Kaatje LePoole, Enrico Lopriore, Johanna M. Middeldorp, Claudia S. Ootjers, Volkher Scharnhorst, Hubertina C. J. Scheepers, Cornelis L. Harteveld, E. J. T. (Joanne) Verweij   +11 more
wiley   +1 more source

Influence of alpha thalassemia on clinical and laboratory parameters among nigerian children with sickle cell anemia

Journal of clinical laboratory analysis (Print), 2018
There is paucity of data on the influence of alpha thalassemia on the clinical and laboratory parameters among Nigerian sickle cell anemia (SCA) patients.
O. Olatunya, D. M. Albuquerque, A. Adekile, F. Costa   +3 more
semanticscholar   +1 more source

Long molecule sequencing: a new approach for identification of clinically significant DNA variants in alpha and beta thalassemia carriers.

Journal of Molecular Diagnostics, 2020
Currently, carrier testing for thalassemia requires the application of different molecular tests to provide an accurate genotype. As an alternative methodology, we evaluated long molecule sequencing (LMS) on the PacBio Sequel platform for genotyping ...
Liangpu Xu, Aiping Mao, Hui Liu, B. Gui, K. Choy, Hailong Huang, Qian Yu, Xiaojie Zhang, Meihuan Chen, N. Lin, Lingji Chen, Jin Han, Yan Wang, Min Zhang, Xiaoyu Li, D. He, Yuan Lin, Jianguang Zhang, D. Cram, Hua Cao   +19 more
semanticscholar   +1 more source

Alpha thalassemia deletions found in suspected cases of beta thalassemia major in Pakistani population

Pakistan Journal of Medical Sciences, 2017
Background & Objective: Alpha (α) thalassemia is a hereditary disorder and is caused by deletions or mutations in globin genes. It is present in two clinically significant forms: hemoglobin Bart hydrops fetalis (Hb Bart) syndrome and hemoglobin H (HbH ...
S. Shahid, M. Nadeem, D. Zahid, J. Hassan, S. Ansari, T. Shamsi   +5 more
semanticscholar   +1 more source

Alpha Thalassemia Disorders

, 2012
The thalassaemias, the commonest monogenic diseases, are a family of inherited disorders of haemoglobin synthesis characterised by a reduced output of one or other of the globin chains of adult haemoglobin. They are likely to pose an increasing health problem for many developing countries during the early part of the new millennium (1).
Arica, Vefik, Arica, Secil Gunher
openaire   +3 more sources

Progress in researches on disease burden and health service utilization of beta-thalassemia patients in China

Zhongguo gonggong weisheng, 2023
Thalassemia is an inherited hemoglobin disorder clinically categorized into alpha and beta thalassemia. Severe beta-thalassemia patients commonly experience anemia during infancy and progressively deteriorate, necessitating long-term blood transfusion to
Jingyi QIAO, Jian MING, Jiaqi YUAN, Bingxing LUO, Junling WENG, Juntao YAN, Yingyao CHEN   +6 more
doaj   +1 more source

Cut-Off Values of Hematologic Parameters to Predict the Number of Alpha Genes Deleted in Subjects with Deletional Alpha Thalassemia

International Journal of Molecular Sciences, 2017
Most α-thalassemia cases are caused by deletions of the structural α-globin genes. The degree of microcytosis and hypochromia has been correlated with the number of affected α-globin genes, suggesting a promising role of hematologic parameters as ...
Diego Velasco-Rodríguez, C. Blas, J. Alonso‐Dominguez, G. Vega, C. Soto, A. García-Raso, P. Llamas-Sillero   +6 more
semanticscholar   +1 more source

Rare double heterozygosity for poly A(A>G) and CD17(A>T) of beta thalassemia intermedia in a Chinese family

Hematology Reports, 2019
Beta thalassemia is a hereditary disorder resulted from mutations in the β globin gene leading to alpha/beta imbalance, ineffective erythropoiesis, and chronic anemia.
Jianhong Xie, Yuqiu Zhou, Qizhi Xiao, Ruoting Long, Lianxiang Li, Lei Li   +5 more
doaj   +1 more source