Results 111 to 120 of about 4,669,562 (299)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Beilstein Journal of Organic ChemistryNon-coding ribonucleic acid (RNA) impacts many biological processes; however, the complexities of its many roles are not completely understood. Therefore, designing tools for molecular recognition is of paramount importance.
Grant D. Walby +10 more
doaj +1 more source
Frontiers in Human NeuroscienceThis study examined the influence of the aesthetics of visual feedback stimuli in neurofeedback training (NFB). Previous research shows a lack of specific design standards in NFB research and its application.
Adrian Naas +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ahi Evran Medical JournalPurpose: Several SARS-CoV-2 variants have emerged during the COVID-19 pandemic and alpha, beta, and delta variants were declared as variants of concern. Our aim is to determine the clinical course and vaccine status of COVID-19 patients with alpha, beta,
Tuğçe Ünalan-altıntop +4 more
doaj +1 more source
Information Theoretic Inequalities as Bounds in Superconformal Field Theory
, 2017 An information theoretic approach to bounds in superconformal field theories is proposed. It is proved that the supersymmetric R\'enyi entropy $\bar S_\alpha$ is a monotonically decreasing function of $\alpha$ and $(\alpha-1)\bar S_\alpha$ is a concave ...
Zhou, Yang
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Existence of infinitely many solutions for the fractional Schr\"odinger- Maxwell equations
, 2015 In this paper, by using variational methods and critical point theory, we shall mainly study the existence of infinitely many solutions for the following fractional Schr\"odinger-Maxwell equations $$( -\Delta )^{\alpha} u+V(x)u+\phi u=f(x,u), \hbox{in } \
Wei, Zhongli
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source