Results 131 to 140 of about 42,921 (251)

DOCK8 deficiency presenting with sclerosing cholangitis, raised immunoglobulin E, and bronchiectasis: A fatal pediatric case report

open access: yesJPGN Reports, Volume 7, Issue 1, Page 11-13, February 2026.
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare autosomal recessive primary immunodeficiency. Patients with DOCK8 deficiency typically present at early age with allergic manifestations, cutaneous and respiratory infections, raised immunoglobulin E, and they have an increased risk of developing malignancies.
Natalia Nedelkopoulou   +4 more
wiley   +1 more source

Pediatric intestinal pseudo‐obstruction found in 3‐year‐old male with Rett‐related mutation of methyl‐CpG binding protein 2

open access: yesJPGN Reports, Volume 7, Issue 1, Page 44-46, February 2026.
Abstract A 3‐year‐old male with chronic abdominal distention, constipation, and severe malnutrition is diagnosed with pediatric intestinal pseudo‐obstruction (PIPO) after extensive evaluation that excluded mechanical, malabsorptive, metabolic, inflammatory, and infectious causes. Aside from speech delay, he has a normal neurologic exam.
Angela Tran, Namrata Patel‐Sanchez
wiley   +1 more source

Volumetric Single‐Molecule Tracking Inside Subcellular Structures

open access: yesSmall, Volume 22, Issue 9, 12 February 2026.
This correlative microscopy approach integrates single‐molecule light‐field microscopy (SMLFM) with widefield Fourier light‐field microscopy (FLFM) to enable 3D single‐molecule tracking within the organelles of living mammalian cells. Instantaneous volumetric segmentation enhances the sensitivity of molecular organization and diffusion measurements ...
Sam Daly   +8 more
wiley   +1 more source

Remote Pancreatic Response to Severe Polytrauma Correlates With Clinical Outcome

open access: yesUnited European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Acute pancreatic injury can result from blunt or sharp force trauma, often leading to serious complications. While direct pancreatic trauma is associated with high rates of infection, organ failure, and mortality, little is known about the pancreas as a potential secondary target and remote trauma organ and thereby as a booster of ...
Rebecca Halbgebauer   +17 more
wiley   +1 more source

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals

open access: yesJournal of Inflammation Research, 2018
Danielle M Dunlea, Laura T Fee, Thomas McEnery, Noel G McElvaney, Emer P Reeves Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland Abstract: Alpha-1 antitrypsin (AAT) is
Dunlea DM   +4 more
doaj  

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

open access: yesAndrology, Volume 14, Issue 2, Page 555-570, February 2026.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco   +6 more
wiley   +1 more source

Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis

open access: yesAlimentary Pharmacology &Therapeutics, Volume 63, Issue 4, Page 494-506, February 2026.
In a multi‐centre study of obeticholic acid in primary biliary cholangitis, 45% discontinued the drug over 4 years, with 11% moving to combination therapy (fibrates). Of those continuing, response rates increased from 37% (1 year) to 55% (4 years). Non‐response at 12 months and cirrhosis were independent predictors of liver‐related events.
Nadir Abbas   +18 more
wiley   +1 more source

Postoperative Atrial Arrhythmias After Lung Transplantation: A Single Center Analysis of Risk Factors, Management, and Outcomes

open access: yesClinical Transplantation, Volume 40, Issue 2, February 2026.
ABSTRACT Background Postoperative atrial arrhythmia (POAA) is common after lung transplant, but data on its implications and management are limited. This study assessed POAA incidence and timing, its association with mortality and rehospitalizations, and outcomes related to postoperative beta‐blocker use.
Daniel M. Chen   +11 more
wiley   +1 more source

Modulation of Immune Cells by Aspirin During Pregnancy

open access: yesImmunology, Volume 177, Issue 2, Page 329-338, February 2026.
This study explores immune and haematological shifts in high‐risk pregnancies, noting lower haemoglobin and platelet levels linked to maternal risk factors. Th2 cell increases support gestational tolerance, while LDA use correlates with reduced cytotoxic NK CD56dim cells and elevated CD56bright NK and naïve Treg cells, suggesting enhanced immune ...
Ana Luísa Areia   +4 more
wiley   +1 more source

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