Results 81 to 90 of about 24,588 (238)

Affinity Proteomics‐Based Non‐Invasive Detection of Clinically Significant Liver Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
Using UK Biobank proteomic data, we identified a five‐protein score reflecting hepatic stellate cell activation and hepatocellular injury that predicts major adverse liver outcomes and clinically significant fibrosis, with consistent performance validated in two independent cohorts (patients with HIV and alpha1‐antitrypsin deficiency).
Sriram Balasubramani, Katharina Remih, Anna Sophie Karl, Julia Alexandra Borchert, Christina Schrader, Malin Fromme, Can Kayatekin, Bailin Zhang, Mikhail Levit, Pavithra Krishnaswami, Louise E. van Eekeren, Leo A. B. Joosten, Twan Otten, Petra Tomanová, Pavel Strnad   +14 more
wiley   +1 more source

Efficacy of alpha1-antitrypsin augmentation therapy in conditions other than pulmonary emphysema [PDF]

, 2011
Up to now alpha 1-antitrypsin (AAT) augmentation therapy has been approved only for commercial use in selected adults with severe AAT deficiency-related pulmonary emphysema (i.e.
Ignacio Blanco, Beatriz Lara, Frederick de Serres   +2 more
core   +1 more source

Diagnostic Impact of Liver Biopsy Among Antinuclear Antibody Positive Individuals With Mild Liver Enzyme Elevation

Alimentary Pharmacology &Therapeutics, EarlyView.
In ANA‐positive patients with suspected autoimmune hepatitis (AIH), liver biopsy rarely altered therapeutic management when alanine aminotransferase (ALT) was below 101 U/L and cirrhosis was absent. These findings suggest that biopsy may be safely deferred in this low‐risk group.
David Mehdi Asgher Niazi, Alphonse Charbel, Jan Pfeiffenberger, Uta Merle, Jessica Seessle, Theresa Wenz, Christa Flechtenmacher, Patrick Michl, Conrad Rauber   +8 more
wiley   +1 more source

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

Molar‐Incisor Hypomineralisation in Children: The Essential Role of Paediatricians

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim Molar‐incisor hypomineralisation is a developmental enamel defect characterised by lower mineral content in the tooth's outer layer, discoloured and structurally fragile teeth that are more prone to sensitivity, breakdown and caries. This review aims to summarise current knowledge on molar‐incisor hypomineralisation and highlight key ...
Sofia Stancati, Viviana Macho, Rita Rodrigues, Cristina Cardoso Silva   +3 more
wiley   +1 more source

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows non-classical behaviour during polymerization [PDF]

, 2017
Severe alpha-1-antitrypsin deficiency (AATD) is most frequently associated with the alpha-1-antitrypsin (AAT) Z variant (E342K). ZZ homozygotes exhibit accumulation of AAT as polymers in the endoplasmic reticulum of hepatocytes.
Bodker, Chiou, Crooks, Dafforn, Ekeowa, Elliott, Ferrarotti, Ferrarotti, Ferrarotti, Fra, Fra, Gaczynska, Gooptu, Haq, Haq, Hess, Irving, Irving, Jensen, Jeppsson, Knaupp, Koloczek, Laurell, Lomas, Lomas, Lomas, Lomas, Luisetti, Mahadeva, Mahadeva, Medicina, Miranda, Miranda, Morena-Barrio, Motamedi-Shad, Ordonez, Pini, Ronzoni, Schneider, Seo, Stein, Tan, Tan, Tsutsui, Tsutsui, Wu, Yamasaki, Yamasaki, Yu, Zhang, Zhou   +50 more
core   +2 more sources

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

A neutrophil-dependent pathway for the generation of a neutral peptide mediator: partial characterization of components and control by alpha-1-antitrypsin. [PDF]

, 1974
A biologically active neutral peptide mediator is cleaved from a plasma protein substrate by an alpha-1-antitrypsin-inhibitable serine protease apparently residing on the membrane of the human neutrophil. The peptide mediator has an approximate mol wt of
Austen, KF, Goetzl, EJ, Wintroub, BU
core  

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein [PDF]

, 2015
A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro molecular scale to the induction of mutant-like oligomerization in a wild-type ...
D. A., Lomas, I., Haq, J. A., Irving, J., Perez, MIRANDA BANOS, MARIA ELENA, N., Motamedi Shad, S. V., Faull, V. R., Kotov   +7 more
core   +2 more sources

Severe Occupational Hypersensitivity Pneumonitis: A Case Series of Four Patients Requiring Lung Transplantation

American Journal of Industrial Medicine, Volume 69, Issue 5, Page 323-334, May 2026.
ABSTRACT Hypersensitivity pneumonitis (HP) is an immune‐mediated interstitial lung disease triggered by repeated inhalation of organic or chemical antigens. Occupational exposures account for approximately 19% of all cases. Early diagnosis, identification of the responsible antigen(s), and immediate avoidance of exposure are crucial to prevent ...
Ludwig Frei‐Stuber, Judith Mohren, Ester Mau, Bernhard Werner, Rudolf A. Hatz, Jürgen Barton, Dennis Nowak   +6 more
wiley   +1 more source