Results 101 to 110 of about 18,796 (222)

Alpha-1 antitrypsin deficiency-associated panniculitis: a case report

Zdravniški Vestnik
Alpha-1 antitrypsin deficiency is a hereditary disorder with predominantly pulmonary but also extrapulmonary manifestations. In the skin, it is associated with panniculitis, a necrotizing neutrophilic inflammation in the subcutis. Clinically, it presents
Špela But, Maja Jerše, Pij Bogomir Marko   +2 more
doaj   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Assessing Major Adverse Liver Outcomes With Baclofen Compared to Acamprosate in Compensated Alcohol‐Associated Cirrhosis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 12, Page 1673-1684, June 2026.
We conducted a nationwide, multicenter cohort study using a target trial emulation framework to compare baclofen and acamprosate in patients with compensated alcohol‐associated cirrhosis. After matching, baclofen initiation was associated with a higher 1‐year risk of major adverse liver outcomes, driven primarily by hepatic encephalopathy, particularly
Yee Hui Yeo, Sepideh Mehravar, Ellen Choi, Ju Dong Yang, Hyun‐Seok Kim, Yun Wang, Aarshi Vipani, Hirsh D. Trivedi, Walid Ayoub, Parnian Naji, Alexander Kuo, Chun‐Ying Wu, Lorenzo Leggio, Juan Pablo Arab   +13 more
wiley   +1 more source

Alpha-1 antitrypsin deficiency in a French General Hospital: fortuitous detection rather than efficient screening

, 2018
Introduction: We studied the characteristics of the screening procedure for alpha-1 antitrypsin at Nevers Hospital (France), together with the performance of serum protein gel electrophoresis for the fortuitous detection of patients with deficiency ...
Kherouf, Hakim; Centre Hospitalier de l'Agglomération de Nevers - Laboratoire de biologie médicale, 1, boulevard de l'Hôpital, 58000 Nevers, France, Bourgerette, Evelyne; Centre Hospitalier de l'Agglomération de Nevers - Laboratoire de biologie médicale, 1, boulevard de l'Hôpital, 58000 Nevers, France, N'Guyen, Tu; Centre Hospitalier de l'Agglomération de Nevers - Département de l'Information médicale, 1, boulevard de l'Hôpital, 58000 Nevers, France, de Faverges, Geoffroy; Centre Hospitalier de l'Agglomération de Nevers - Service de Pneumologie, 1, boulevard de l'Hôpital, 58000 Nevers, France, Moquet, Olivier; Centre Hospitalier de l'Agglomération de Nevers - Laboratoire de biologie médicale, 1, boulevard de l'Hôpital, 58000 Nevers, France, Dumont, Pierre; Centre Hospitalier de l'Agglomération de Nevers - Laboratoire de biologie médicale, 1, boulevard de l'Hôpital, 58000 Nevers, France   +5 more
core   +1 more source

High BMI and COPD Outcomes in Alpha-1 Antitrypsin DeficiencyTake-Home Points

CHEST Pulmonary
Background: Elevations in BMI impact morbidity in patients with COPD in general, but little is known about its impact in patients with COPD due to alpha-1 antitrypsin deficiency (AATD-COPD).
Michael A. Campos, MD, Leonard Riley, MD, Jorge Lascano, MD, Brian Garnet, MD, Robert Sandhaus, MD, PhD   +4 more
doaj   +1 more source

Respiratory Biomarkers: An Opportunity for Patient‐Centric Microsampling Approach for Treatment Optimization

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
Overview of patient centric microsampling approach for monitoring respiratory biomarkers for treatment optimization. Image created in BioRender. Khan, A. (2026) https://BioRender.com/17jm5cs. ABSTRACT The clinical heterogeneity of respiratory disorders emphasizes the need for personalized approaches to prevention, diagnosis, and therapy.
Ahmar Khan, Jacqueline L. Stair, Daniel Baker, Neil Spooner, Darragh Murnane   +4 more
wiley   +1 more source

Hepatitis B Surface Antigen Loss and Improved Clinical Outcomes in US Individuals With Chronic Hepatitis B Virus Infection

Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.
ABSTRACT Hepatitis B surface antigen (HBsAg) loss is associated with improved clinical outcomes in patients with chronic hepatitis B virus (HBV) infection based on studies predominantly in Asian populations. We assessed real‐world associations between HBsAg loss and long‐term clinical outcomes in a diverse US population with chronic HBV infection. This
Myriam Drysdale, Rose Chang, Shuang Wang, Anna Coutinho, Vera Gielen, Theo Man, Rui Song, Mei Sheng Duh, Mandana Khalili, Dickens Theodore   +9 more
wiley   +1 more source

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency

, 2009
Irina Petrache1, Joud Hajjar1, Michael Campos21Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; 2Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Miller School of Medicine ...
Campos, Michael, Michael Campos, Irina Petrache, Joud Hajjar, Hajjar, Joud, Petrache, Irina   +5 more
core  

Alpha 1 Antitrypsin Therapy in Patients with Alpha 1 Antitrypsin Deficiency: Perspectives from a Registry Study and Practical Considerations for Self-Administration During the COVID-19 Pandemic

International Journal of COPD, 2021
Felix JF Herth,1 Robert A Sandhaus,2 Alice M Turner,3 Maria Sucena,4 Tobias Welte,5 Timm Greulich6 1Department of Pneumology and Critical Care Medicine, University of Heidelberg, Heidelberg, Germany; 2Division of Pulmonary, Critical Care and Sleep ...
Herth FJF, Sandhaus RA, Turner AM, Sucena M, Welte T, Greulich T   +5 more
doaj  

ABO Incompatible Deceased Donor Liver Transplants in Infants (Age < 1 Year): A Single‐Center Experience

Pediatric Transplantation, Volume 30, Issue 6, June 2026.
The liver transplant waitlist mortality for infants (age < 1 year) is currently the highest among all ages. ABO incompatible (ABOi) liver‐transplantation is one of the strategies to increase transplantation rate in infants and can be safely performed in children less than 1 year of age without plasmapheresis, with excellent long‐term outcomes. ABSTRACT
Heli Bhatt, Sarah Kizilbash, Claudia Cohn, Oyedele Adeyi, Daniel Waller, David M. Vock, Gwenyth Fischer, Joseph Resch, Andrew Adams, Srinath Chinnakotla   +9 more
wiley   +1 more source