Frontiers in Cell and Developmental Biology, 2020 SERine Protein INhibitor-A1 (SERPINA1) is an inducible blood cell gene coding for alpha1-antitrypsin (AAT), a plasma protease inhibitor whose circulating levels are raised during inflammation, infection and advanced pregnancy.
John Charles Rotondo +2 more
exaly +4 more sources
SERPINA1 as a Shared Biomarker in Periodontitis and Oral Squamous Cell Carcinoma [PDF]
International Dental JournalObjective: Periodontitis (PD) and oral squamous cell carcinoma (OSCC) frequently co‑occur in clinical populations. However, shared molecular determinants that could support risk assessment across diseases remain insufficiently defined.
Jingkun Zhang +4 more
doaj +4 more sources
Role of SERPINA1 in the tumor immune microenvironment of breast cancer and construction of a prognostic model [PDF]
Discover OncologyBackground Breast cancer is a common malignancy where the immune system plays a key role in disease progression and treatment response. SERPINA1 is an immune-related gene, but its function in breast cancer remains unclear.
Xiaolin Xia +4 more
doaj +3 more sources
Grass carp SERPINA1 inhibits GCRV infection through degrading CF2
Frontiers in Immunology, 2022 SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Zuoyan Zhu, Lanjie Liao, Bin Gui
exaly +3 more sources
Meta-Analysis: Redefining Liver Disease Risk in Heterozygous Alpha-1 Antitrypsin Deficiency. [PDF]
Aliment Pharmacol TherSERPINA1 MZ/SZ genotypes is a common but under‐recognised liver risk state. Despite modest shifts in liver function tests, it is associated with approximately doubled odds of fibrosis, cirrhosis, and liver transplantation, supporting its inclusion in chronic liver disease risk assessment.
Syanda AM +8 more
europepmc +2 more sources
AAT/SERPINA1 Pi*Z variant linked to gestational length and preterm birth prevention via AAT in mice [PDF]
Nature CommunicationsAbout 10% of pregnancies end prematurely before 37 weeks, without effective prevention therapies. Previously, we identified rare damaging variants in SERPINA1 encoding alpha-1-antitrypsin (AAT) in families with recurrent spontaneous preterm births and ...
E. Koivulehto +5 more
doaj +2 more sources
Exploring the causal role and mechanism of galanin in glioblastoma: integration of mendelian randomization, network analysis, molecular docking and experimental validation [PDF]
Frontiers in PharmacologyBackgroundGlioblastoma (GBM) is a highly malignant central nervous system tumor with an exceptionally poor prognosis. The neuropeptide Galanin is implicated in GBM development, but its specific molecular mechanisms and therapeutic potential remain ...
Haimin Song +7 more
doaj +2 more sources
Discover OncologyPurpose Previous studies have suggested that SERPINA1 may promote a better prognosis in papillary thyroid carcinoma (PTC) along with Hashimoto's thyroiditis (HT).
Xiuyuan Du, Wanjun Chen
exaly +2 more sources
Do LRG1–SERPINA1 Interactions Modulate Fibrotic and Inflammatory Signatures in Rheumatoid Arthritis? A Proteomic and In Silico Investigation [PDF]
PathophysiologyBackground: Rheumatoid arthritis (RA) is a systemic, pro-inflammatory, autoimmune disease that mainly affects the joints in a symmetrical manner. Differential proteomic profiling through Sequential Window Acquisition of all Theoretical Fragment Ion Mass ...
Talib Hussain +2 more
doaj +2 more sources
SERPINA1 gene regulates the tumorigenesis and progression of breast cancer through PI3K/AKT signaling pathway and tumor immune microenvironment [PDF]
Scientific ReportsThis study aims to reveal the influence of SERPINA1 gene on the development, prognosis evaluation and immune environment changes of breast cancer. Cell lines with differential SERPINA1 expression were constructed.
Chuqi Lei +7 more
doaj +2 more sources