Results 1 to 10 of about 6,824 (156)

Grass carp SERPINA1 inhibits GCRV infection through degrading CF2

Frontiers in Immunology, 2022
SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Liangming Chen, Yangyu Li, Bin Gui
exaly   +5 more sources

SERPINA1 as a Shared Biomarker in Periodontitis and Oral Squamous Cell Carcinoma [PDF]

International Dental Journal
Objective: Periodontitis (PD) and oral squamous cell carcinoma (OSCC) frequently co‑occur in clinical populations. However, shared molecular determinants that could support risk assessment across diseases remain insufficiently defined.
Jingkun Zhang, Guangwei Chen, Qi Wang, Yali Chi, Guoxu Han   +4 more
doaj   +4 more sources

SERPINA1 is a new frontier in cancer immunotherapy and drug targeting by pan-cancer analysis [PDF]

Discover Oncology
Background The immune response can be modulated by autophagy to alter tumor growth. SERPINA1 is not only an autophagy-related protein but also a serine protease inhibitor with the potential for immunotherapy and targeted drug therapy.
Chen Fu, Yanyun Hu, Lei Yang, Weifeng Sun   +3 more
exaly   +3 more sources

Role of SERPINA1 in the tumor immune microenvironment of breast cancer and construction of a prognostic model [PDF]

Discover Oncology
Background Breast cancer is a common malignancy where the immune system plays a key role in disease progression and treatment response. SERPINA1 is an immune-related gene, but its function in breast cancer remains unclear.
Xiaolin Xia, Jiaqi Liu, Jine Liu, Shuai Chen, Zhou Chen   +4 more
doaj   +2 more sources

Clinical Exome Sequencing in Unexplained Hyperferritinemia Reveals Digenic and Oligogenic Inheritance Beyond Iron Homeostasis. [PDF]

Liver Int
ABSTRACT Background and Aims Hyperferritinemia encompasses heterogeneous genetic etiologies beyond HFE‐related hemochromatosis. Current guidelines recommend testing for rare hemochromatosis genes, yet no consensus exists on comprehensive genomic approaches.
Morel P, Silva Rodriguez M, Benmouffek C, Goksen B, Chéry C, Haghnejad V, Bensenane M, Feillet F, Guéant JL, Namour F, Bronowicki JP, Oussalah A.   +11 more
europepmc   +2 more sources

SERPINA1 Gene Promoter Is Differentially Methylated in Peripheral Blood Mononuclear Cells of Pregnant Women

Frontiers in Cell and Developmental Biology, 2020
SERine Protein INhibitor-A1 (SERPINA1) is an inducible blood cell gene coding for alpha1-antitrypsin (AAT), a plasma protease inhibitor whose circulating levels are raised during inflammation, infection and advanced pregnancy.
John Charles Rotondo, Lucia Oton-Gonzalez, Rita Selvatici   +2 more
exaly   +3 more sources

SERPINA1 gene regulates the tumorigenesis and progression of breast cancer through PI3K/AKT signaling pathway and tumor immune microenvironment [PDF]

Scientific Reports
This study aims to reveal the influence of SERPINA1 gene on the development, prognosis evaluation and immune environment changes of breast cancer. Cell lines with differential SERPINA1 expression were constructed.
Chuqi Lei, Wei Lu, Yuan Li, Huaiyu yang, Ke Zhang, Nianchang Wang, Lixue Xuan, Changyuan Guo   +7 more
doaj   +2 more sources

Do LRG1–SERPINA1 Interactions Modulate Fibrotic and Inflammatory Signatures in Rheumatoid Arthritis? A Proteomic and In Silico Investigation [PDF]

Pathophysiology
Background: Rheumatoid arthritis (RA) is a systemic, pro-inflammatory, autoimmune disease that mainly affects the joints in a symmetrical manner. Differential proteomic profiling through Sequential Window Acquisition of all Theoretical Fragment Ion Mass ...
Talib Hussain, Monika Verma, Sagarika Biswas   +2 more
doaj   +2 more sources

Dysregulated Protease Homeostasis Defines Primary FSGS [PDF]

Kidney360
Key Points. Serum proteomics reveals reduced serpin family A member 1 (SERPINA1) in primary FSGS, distinguishing it from other proteinuric kidney diseases.
Johannes Schmidt, Nina Sopel, Carmen Rist, Alexandra Ohs, Laura Dawid, Stefan Simm, Lorenzo Catanese, Harald Rupprecht, Tilman Jobst-Schwan, Jörg Lehmann, Christoph Daniel, Stefan Kalkhof, Mario Schiffer, Janina Müller-Deile   +13 more
doaj   +2 more sources

The Alpha-1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD. [PDF]

Aliment Pharmacol Ther
Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Balcar L, Semmler G, Scheiner B, Paternostro R, Simbrunner B, Haunold TJ, Jachs M, Hartl L, Hofer BS, Dominik N, Schwarz M, Kramer G, Sebesta C, Thöne P, Pinter M, Trauner M, Reiberger T, Stättermayer AF, Mandorfer M.   +18 more
europepmc   +2 more sources