Grass carp SERPINA1 inhibits GCRV infection through degrading CF2
Frontiers in Immunology, 2022 SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Liangming Chen, Zuoyan Zhu
exaly +5 more sources
SERPINA1 as a Shared Biomarker in Periodontitis and Oral Squamous Cell Carcinoma [PDF]
International Dental JournalObjective: Periodontitis (PD) and oral squamous cell carcinoma (OSCC) frequently co‑occur in clinical populations. However, shared molecular determinants that could support risk assessment across diseases remain insufficiently defined.
Jingkun Zhang +4 more
doaj +4 more sources
SERPINA1 is a new frontier in cancer immunotherapy and drug targeting by pan-cancer analysis [PDF]
Discover OncologyBackground The immune response can be modulated by autophagy to alter tumor growth. SERPINA1 is not only an autophagy-related protein but also a serine protease inhibitor with the potential for immunotherapy and targeted drug therapy.
Chen Fu +3 more
exaly +3 more sources
Role of SERPINA1 in the tumor immune microenvironment of breast cancer and construction of a prognostic model [PDF]
Discover OncologyBackground Breast cancer is a common malignancy where the immune system plays a key role in disease progression and treatment response. SERPINA1 is an immune-related gene, but its function in breast cancer remains unclear.
Xiaolin Xia +4 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2020 SERine Protein INhibitor-A1 (SERPINA1) is an inducible blood cell gene coding for alpha1-antitrypsin (AAT), a plasma protease inhibitor whose circulating levels are raised during inflammation, infection and advanced pregnancy.
John Charles Rotondo +2 more
exaly +3 more sources
SERPINA1 gene regulates the tumorigenesis and progression of breast cancer through PI3K/AKT signaling pathway and tumor immune microenvironment [PDF]
Scientific ReportsThis study aims to reveal the influence of SERPINA1 gene on the development, prognosis evaluation and immune environment changes of breast cancer. Cell lines with differential SERPINA1 expression were constructed.
Chuqi Lei +7 more
doaj +2 more sources
Dysregulated Protease Homeostasis Defines Primary FSGS [PDF]
Kidney360Key Points. Serum proteomics reveals reduced serpin family A member 1 (SERPINA1) in primary FSGS, distinguishing it from other proteinuric kidney diseases.
Johannes Schmidt +13 more
doaj +2 more sources
Do LRG1–SERPINA1 Interactions Modulate Fibrotic and Inflammatory Signatures in Rheumatoid Arthritis? A Proteomic and In Silico Investigation [PDF]
PathophysiologyBackground: Rheumatoid arthritis (RA) is a systemic, pro-inflammatory, autoimmune disease that mainly affects the joints in a symmetrical manner. Differential proteomic profiling through Sequential Window Acquisition of all Theoretical Fragment Ion Mass ...
Talib Hussain +2 more
doaj +2 more sources
Discover OncologyPurpose Previous studies have suggested that SERPINA1 may promote a better prognosis in papillary thyroid carcinoma (PTC) along with Hashimoto's thyroiditis (HT).
Xiuyuan Du, Wanjun Chen
exaly +2 more sources
Functional and clinical significance of novel SERPINA1 variants on alpha-1 antitrypsin deficiency [PDF]
Respiratory ResearchBackground Mutations in the SERPINA1 gene can result in alpha-1 antitrypsin deficiency (AATD), which may be associated with lung or liver injury. Although the S and Z alleles account for over 95% of cases of AATD, a wide variety of rare variants have ...
Nerea Matamala +22 more
doaj +2 more sources