Results 21 to 30 of about 10,966 (204)

Prognostic Value of SERPINA1 as a Biomarker for Poor Survival of Gliomas

Journal of Medical Sciences
Background: Glioma is a primary brain tumor known for its aggressive behavior and poor prognosis. Alpha-1 antitrypsin (SERPINA1) is a protein with a crucial role in regulating inflammatory processes in the body.
Nai-Jui Cheng, Hao-Yuan Hung, Tzu-Tsao Chung, Wen-Shin Song, Kun-Ting Hong, Dueng-Yuan Hueng   +5 more
doaj   +2 more sources

Fusion transcripts landscape in hepatocellular carcinoma and potential impact on the expression of fusion partners [PDF]

RNA Biology
Fusion transcripts (FTs) are RNA molecules, also known as chimeric transcripts, formed through chromosomal rearrangements or transcriptional processes, contributing to tumorigenesis.
Yasemin Öztemur Islakoğlu, Peyda Korhan, Leman Binokay, Barış Keleş, Ezgi Bağırsakçı, Meryem Uludağ Taşçıoğlu, Emine Şamdancı, Gökhan Karakülah, Neşe Atabey   +8 more
doaj   +2 more sources

Clinical Exome Sequencing in Unexplained Hyperferritinemia Reveals Digenic and Oligogenic Inheritance Beyond Iron Homeostasis. [PDF]

Liver Int
ABSTRACT Background and Aims Hyperferritinemia encompasses heterogeneous genetic etiologies beyond HFE‐related hemochromatosis. Current guidelines recommend testing for rare hemochromatosis genes, yet no consensus exists on comprehensive genomic approaches.
Morel P, Silva Rodriguez M, Benmouffek C, Goksen B, Chéry C, Haghnejad V, Bensenane M, Feillet F, Guéant JL, Namour F, Bronowicki JP, Oussalah A.   +11 more
europepmc   +2 more sources

Identification and characterisation of eight novel SERPINA1 Null mutations [PDF]

Orphanet Journal of Rare Diseases, 2014
Alpha-1 antitrypsin (AAT) is the most abundant circulating antiprotease and is a member of the serine protease inhibitor (SERPIN) superfamily. The gene encoding AAT is the highly polymorphic SERPINA1 gene, found at 14q32.1. Mutations in the SERPINA1 gene can lead to AAT deficiency (AATD) which is associated with a substantially increased risk of lung ...
Ferrarotti I., Carroll T. P., Ottaviani S., FRA, Annamaria, Brien G. O., Molloy K., Corda L., Medicina D., Curran D. R., McElvaney N. G., Luisetti M.   +10 more
openaire   +6 more sources

Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity

Open Medicine, 2022
Serpin family A member 1 (SERPINA1) is expressed abundantly in gliomas and can predict unfavorable prognosis of patients with glioma. Studies have shown that nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (NQO1) can promote the ...
Liu Wenjun, Du Min, Wan Hongping, Yang Hao, Deng Xiaorong, Chen Yu, Zhang Qian   +6 more
doaj   +1 more source

SERPINA1 gene polymorphisms in a population‐based ALSPAC cohort [PDF]

Pediatric Pulmonology, 2019
Abstract Background There is an association between persistent preschool wheezing phenotypes and school‐age asthma. These wheezing/asthma phenotypes likely represent clinical entities having specific genetic risk factors.
David S. DeLuca, Edita Poluzioroviene, Vaida Taminskiene, Sabine Wrenger, Algirdas Utkus, Algirdas Valiulis, Tomas Alasevičius, John Henderson, Andrew Bush, Tobias Welte, Sabina Janciauskiene, Arunas Valiulis   +11 more
openaire   +7 more sources

SERPINA1 modulates expression of amyloidogenic transthyretin

Experimental Cell Research, 2020
Hereditary transthyretin amyloidosis (ATTR) is caused by amyloid deposition of misfolded transthyretin (TTR) in various tissues. Recently, reduction of circulating serum TTR, achieved via silencing oligonucleotides, was introduced as therapy of ATTR amyloidosis.
Christoph, Niemietz, Filipa, Bezerra, Maria Rosário, Almeida, Shuling, Guo, Brett P, Monia, Maria João, Saraiva, Paula, Schütz, Hartmut H-J, Schmidt, Andree, Zibert   +8 more
openaire   +2 more sources

SERPINA1 Peptides in Urine as A Potential Marker of Preeclampsia Severity [PDF]

International Journal of Molecular Sciences, 2020
Preeclampsia (PE) is a multisystem disorder associated with pregnancy and its frequency varies from 5 to 20 percent of pregnancies. Although a number of preeclampsia studies have been carried out, there is no consensus about disease etiology and pathogenesis so far. Peptides of SERPINA1 (α1-antitrypsin) in urine remain one of the most promising peptide
Natalia Starodubtseva, Natalia Nizyaeva, Oleg Baev, Anna Bugrova, Masara Gapaeva, Kamilla Muminova, Alexey Kononikhin, Vladimir Frankevich, Eugene Nikolaev, Gennady Sukhikh   +9 more
openaire   +2 more sources

Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank [PDF]

ERJ Open Research, 2021
Homozygosity for the SERPINA1 Z allele causes α 1 -antitrypsin deficiency, a rare condition that can cause lung and liver disease. However, the effects of Z allele heterozygosity on nonrespiratory phenotypes, and on lung function in the general ...
Katherine A. Fawcett, Kijoung Song, Guoqing Qian, Aliki-Eleni Farmaki, Richard Packer, Catherine John, Nick Shrine, Raquel Granell, Sue Ring, Nicholas J. Timpson, Laura M. Yerges-Armstrong, Richard Eastell, Louise V. Wain, Robert A. Scott, Martin D. Tobin, Ian P. Hall   +15 more
openaire   +8 more sources

Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells

Frontiers in Endocrinology, 2022
Endometriosis is characterized by the presence of inflamed and fibrotic endometrial tissue outside the uterine cavity. Previously, we found decreased SERPINA1 (alpha-1 antitrypsin) expression in endometriosis-like lesions in a mouse model of ...
Kazuya Kusama, Ayaka Satoyoshi, Mana Azumi, Mikihiro Yoshie, Junya Kojima, Yumi Mizuno, Masanori Ono, Hirotaka Nishi, Takeshi Kajihara, Kazuhiro Tamura   +9 more
doaj   +1 more source