Results 21 to 30 of about 8,184 (185)

Dysregulated Protease Homeostasis Defines Primary FSGS [PDF]

Kidney360
Key Points. Serum proteomics reveals reduced serpin family A member 1 (SERPINA1) in primary FSGS, distinguishing it from other proteinuric kidney diseases.
Johannes Schmidt, Nina Sopel, Carmen Rist, Alexandra Ohs, Laura Dawid, Stefan Simm, Lorenzo Catanese, Harald Rupprecht, Tilman Jobst-Schwan, Jörg Lehmann, Christoph Daniel, Stefan Kalkhof, Mario Schiffer, Janina Müller-Deile   +13 more
doaj   +2 more sources

Misfolding linked mutations of SERPINA1 gene are uncommon in preeclampsia

Archives of Medicine and Health Sciences, 2019
Background: Alpha-1 antitrypsin (A1AT) is a protease inhibitor that plays an important role in regulating oxidative stress in preeclampsia (PE). Recent studies have shown that A1AT is misfolded in PE.
Chandrakala Nagarajappa, Sheela Shikaripur Rangappa, Sharath Balakrishna   +2 more
doaj   +2 more sources

Prognostic Value of SERPINA1 as a Biomarker for Poor Survival of Gliomas

Journal of Medical Sciences
Background: Glioma is a primary brain tumor known for its aggressive behavior and poor prognosis. Alpha-1 antitrypsin (SERPINA1) is a protein with a crucial role in regulating inflammatory processes in the body.
Nai-Jui Cheng, Hao-Yuan Hung, Tzu-Tsao Chung, Wen-Shin Song, Kun-Ting Hong, Dueng-Yuan Hueng   +5 more
doaj   +2 more sources

SERPINA1 methylation as a novel diagnostic marker for early-stage papillary thyroid carcinoma via MAPK6-AKT/mTOR pathway

Clinical Epigenetics
Most thyroid nodules can be diagnosed preoperatively by ultrasonography and fine-needle aspiration biopsy. However, accurately differentiating between benign nodules or indolent thyroid tumors and aggressive thyroid cancers remains a significant clinical
Junjie Li, Haixia Huang, Yifei Yin, Yizhu Mao, Mengxia Li, Hong Li, Chenxia Jiang, Rongxi Yang   +7 more
doaj   +2 more sources

Prevalence of SERPINA1 mutations in a bronchiectasis cohort: implications of extended screening for alpha-1 antitrypsin deficiency [PDF]

Jornal Brasileiro de Pneumologia
Objective: To evaluate the prevalence of alpha-1 antitrypsin (AAT) variants through SERPINA1 genotyping in patients with non-cystic fibrosis bronchiectasis, and assess their clinical, functional and radiological characteristics.
Caroline Souza Sokoloski, Mariane Gonçalves Martynychen Canan, Cleverson Alex Leitão, Karin Mueller Storrer   +3 more
doaj   +2 more sources

Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study

International Journal of COPD, 2017
Xiaowei Deng,1 Cun-hua Yuan,1 De Chang2 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China Background: SERPINA1 gene has been implicated
Deng XW, Yuan CH, Chang D
doaj   +1 more source

Identification and characterisation of seven novel SERPINA1 null mutations

European Respiratory Journal, 2014
Background- Alpha-1 antitrypsin (AAT) is a serine protease inhibitor, encoded by the highly polymorphic SERPINA1 gene. Mutations in this gene can lead to AAT deficiency (AATD) which is associated with a substantially increased risk of lung and liver ...
Carroll Tomas P., Ferrarotti Ilaria, Corda Luciano, FRA, Annamaria, O'Brien Geraldine, Ottaviani Stefania, Luisetti Maurizio, McElvaney Noel G., Molloy Kevin   +8 more
core   +3 more sources

Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways [PDF]

, 2022
The SERPINA1 gene encodes alpha1-antitrypsin (AAT), an acute phase glycoprotein and serine protease inhibitor that is mainly (80–90%) produced in the liver. Point mutations in the SERPINA1 gene can lead to the misfolding, intracellular accumulation,
DeLuca, David S, Lena Ostermann, DeLuca, David, Wrenger Sabine, Gomez-Mariano, Gema Maria, Martinez-Delgado, Beatriz, Ulrich A Maus, Welte, Tobias, Sri Harsha Meghadri, DeLuca, David S., Gema Gomez-Mariano, Tobias Welte, Janciauskiene, Sabina, Meghadri, Sri Harsha, David S. DeLuca, Maus, Ulrich A, Sabina Janciauskiene, Wrenger, Sabine, Sabine Wrenger, Pérez Luz, Sara, Ulrich A. Maus, Gomez-Mariano, Gema, Ostermann, Lena, Sara Perez-Luz, Maus, Ulrich A., Beatriz Martinez-Delgado, Srinu Tumpara, Tumpara, Srinu, Perez-Luz, Sara   +28 more
core   +1 more source

Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity

Open Medicine, 2022
Serpin family A member 1 (SERPINA1) is expressed abundantly in gliomas and can predict unfavorable prognosis of patients with glioma. Studies have shown that nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (NQO1) can promote the ...
Liu Wenjun, Du Min, Wan Hongping, Yang Hao, Deng Xiaorong, Chen Yu, Zhang Qian   +6 more
doaj   +1 more source

SERPINA1 modulates expression of amyloidogenic transthyretin

Experimental Cell Research, 2020
Hereditary transthyretin amyloidosis (ATTR) is caused by amyloid deposition of misfolded transthyretin (TTR) in various tissues. Recently, reduction of circulating serum TTR, achieved via silencing oligonucleotides, was introduced as therapy of ATTR amyloidosis.
Christoph, Niemietz, Filipa, Bezerra, Maria Rosário, Almeida, Shuling, Guo, Brett P, Monia, Maria João, Saraiva, Paula, Schütz, Hartmut H-J, Schmidt, Andree, Zibert   +8 more
openaire   +2 more sources