Results 1 to 10 of about 5,912 (202)

Association of A1AT With Poor Functional Outcome in Patients With Acute Ischemic Stroke [PDF]

Journal of the American Heart Association
Background This study aimed to investigate whether A1AT (α‐1 antitrypsin) bloodstream levels, measured acutely after ischemic stroke, can predict the outcome of patients with stroke.
Paula García-Rodríguez, Laura Ramiro, Alba Simats Oriol   +2 more
exaly   +10 more sources

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis [PDF]

Experimental and Molecular Medicine
Metabolic dysfunction-associated steatohepatitis (MASH) is associated with the activation of Kupffer cells (KCs) and hepatic stellate cells, at which point a metabolically stressed hepatocyte becomes integral to the progression of the disease.
Jeong-Su Park, Jin Lee, Feng Wang, Hwan Ma, Zixiong Zhou, Yong-Sun Lee, Kwangyeon Oh, Haram Lee, Guoyan Sui, Sangkyu Lee, Yoon Mee Yang, Jang-Won Lee, Yong-Ha Ji, Chun-Woong Park, Hwan-Soo Yoo, Bang-Yeon Hwang, Sang-Bae Han, Nan Song, Soohwan Oh, Bumseok Kim, Ekihiro Seki, Jin Tae Hong, Yoon Seok Roh   +22 more
exaly   +6 more sources

FBG1 Is the Final Arbitrator of A1AT-Z Degradation [PDF]

PLoS ONE, 2015
Alpha-1 antitrypsin deficiency is the leading cause of childhood liver failure and one of the most common lethal genetic diseases. The disease-causing mutant A1AT-Z fails to fold correctly and accumulates in the endoplasmic reticulum (ER) of the liver ...
Katherine N Gibson-Corley
exaly   +6 more sources

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression [PDF]

Scientific Reports
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency.
Abigail Hatfield, Vijay Shankar, Lela Lackey   +2 more
exaly   +3 more sources

Scaled up fed-batch production of recombinant alpha-1-antitrypsin by CHO cells in single-use surface aerated orbital shaken bioreactor [PDF]

Scientific Reports
Augmentation therapy is a treatment option available in the market that has been approved by the U.S. Food and Drug Administration (FDA) for alpha-1-antitrypsin (A1AT) deficient patients.
Wen Qin Tang, Chloe Qiu Zhen Jiang, Zi Ying Zheng, Ally Lau, Xuezhi Bi, Wei Zhang, Say Kong Ng   +6 more
doaj   +2 more sources

a1-antitrypsin, a new biomarker of polycystic ovary syndrome by changing its expression and rhythm [PDF]

Journal of Ovarian Research
Background Previous proteomic studies have demonstrated the potential for identifying specific diagnostic biomarkers in the plasma and follicular fluid of patients with polycystic ovary syndrome (PCOS), which was utilized to elucidate the underlying ...
Na Li, Beilei Shen, Wei Cao, RouRou Chen, Rongbo He, Li Qian, Lin Xu, Yu Liu   +7 more
doaj   +2 more sources

Case Report: Pseudomonas liver abscess in a previously healthy child with homozygous pathogenic S allele variant of the SERPINA1 gene [PDF]

Frontiers in Immunology
BackgroundPyogenic liver abscess is an uncommon pediatric condition, and Pseudomonas aeruginosa represents a rare causative agent in otherwise healthy children. Such infections may signal an underlying inborn error of immunity. Alpha-1 antitrypsin (A1AT),
Sanya Thomas, Sanya Thomas, Alaric W. D’Souza, Alaric W. D’Souza, Alaric W. D’Souza, Musaab Alhezam, Musaab Alhezam, Craig D. Platt, Craig D. Platt, Ofer Levy, Ofer Levy, Ofer Levy   +11 more
doaj   +2 more sources

Role of the alpha-1 antitrypsin in the progression and severity of COVID-19 infection among Saudi patients [PDF]

BMC Infectious Diseases
Background Alpha-1 antitrypsin (A1AT) is involved in pathophysiology of severe COVID-19, including thrombosis expansion. A1AT has anti-inflammatory, tissue-protective, and anticoagulant capabilities.
Rabab A. Ali, Walaa A. Mohammedsaeed, Mohamed Hisham A. Fakher, Hala K. Noor, Yasir M. Al Qurashi   +4 more
doaj   +2 more sources

Immunological and homeostatic pathways of alpha -1 antitrypsin: a new therapeutic potential [PDF]

Frontiers in Immunology
α -1 antitrypsin (A1AT) is a 52 kDa acute-phase glycoprotein belonging to the serine protease inhibitor superfamily (SERPIN). It is primarily synthesized by hepatocytes and to a lesser extent by monocytes, macrophages, intestinal epithelial cells, and ...
Carmen Mazzuca, Carmen Mazzuca, Laura Vitiello, Silvia Travaglini, Fatima Maurizi, Panaiotis Finamore, Simona Santangelo, Amelia Rigon, Marta Vadacca, Silvia Angeletti, Simone Scarlata   +10 more
doaj   +2 more sources

Combination of alpha-1 antitrypsin (A1AT) and anti-TNFα as a neuroprotective strategy in the early stages after ischemic stroke [PDF]

Journal of Cerebral Blood Flow and Metabolism
Paula García-Rodríguez, Laura Ramiro, Alba Simats Oriol   +2 more
exaly   +2 more sources