Results 1 to 10 of about 3,462 (201)

Association of A1AT With Poor Functional Outcome in Patients With Acute Ischemic Stroke [PDF]

Journal of the American Heart Association
Background This study aimed to investigate whether A1AT (α‐1 antitrypsin) bloodstream levels, measured acutely after ischemic stroke, can predict the outcome of patients with stroke.
Paula García-Rodríguez, Laura Ramiro, Alba Simats   +2 more
exaly   +12 more sources

FBG1 Is the Final Arbitrator of A1AT-Z Degradation [PDF]

PLoS ONE, 2015
Alpha-1 antitrypsin deficiency is the leading cause of childhood liver failure and one of the most common lethal genetic diseases. The disease-causing mutant A1AT-Z fails to fold correctly and accumulates in the endoplasmic reticulum (ER) of the liver ...
Katherine N Gibson-Corley, Kevin A Glenn
exaly   +7 more sources

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis [PDF]

Experimental and Molecular Medicine
Metabolic dysfunction-associated steatohepatitis (MASH) is associated with the activation of Kupffer cells (KCs) and hepatic stellate cells, at which point a metabolically stressed hepatocyte becomes integral to the progression of the disease.
Bang-Yeon Hwang, Yoon Seok Roh, Lee Jin   +2 more
exaly   +8 more sources

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression [PDF]

Scientific Reports
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency.
Vijay Shankar, Lela Lackey, Shankar Vijay   +2 more
exaly   +3 more sources

From the Proteome to Therapeutics: A Multi-Database Approach to Drug Discovery in Periodontitis-An Exploratory Pilot Study. [PDF]

J Clin Periodontol
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Bozo T, Murr A, Holtfreter B, Baumeister SE, Meisel P, Völker U, Weitschies W, Völzke H, Kanzow P, Hammer E, Salazar MG, Kocher T.   +11 more
europepmc   +2 more sources

Scaled up fed-batch production of recombinant alpha-1-antitrypsin by CHO cells in single-use surface aerated orbital shaken bioreactor [PDF]

Scientific Reports
Augmentation therapy is a treatment option available in the market that has been approved by the U.S. Food and Drug Administration (FDA) for alpha-1-antitrypsin (A1AT) deficient patients.
Wen Qin Tang, Chloe Qiu Zhen Jiang, Zi Ying Zheng, Ally Lau, Xuezhi Bi, Wei Zhang, Say Kong Ng   +6 more
doaj   +2 more sources

a1-antitrypsin, a new biomarker of polycystic ovary syndrome by changing its expression and rhythm [PDF]

Journal of Ovarian Research
Background Previous proteomic studies have demonstrated the potential for identifying specific diagnostic biomarkers in the plasma and follicular fluid of patients with polycystic ovary syndrome (PCOS), which was utilized to elucidate the underlying ...
Na Li, Beilei Shen, Wei Cao, RouRou Chen, Rongbo He, Li Qian, Lin Xu, Yu Liu   +7 more
doaj   +2 more sources

Case Report: Pseudomonas liver abscess in a previously healthy child with homozygous pathogenic S allele variant of the SERPINA1 gene [PDF]

Frontiers in Immunology
BackgroundPyogenic liver abscess is an uncommon pediatric condition, and Pseudomonas aeruginosa represents a rare causative agent in otherwise healthy children. Such infections may signal an underlying inborn error of immunity. Alpha-1 antitrypsin (A1AT),
Sanya Thomas, Sanya Thomas, Alaric W. D’Souza, Alaric W. D’Souza, Alaric W. D’Souza, Musaab Alhezam, Musaab Alhezam, Craig D. Platt, Craig D. Platt, Ofer Levy, Ofer Levy, Ofer Levy   +11 more
doaj   +2 more sources

Role of the alpha-1 antitrypsin in the progression and severity of COVID-19 infection among Saudi patients [PDF]

BMC Infectious Diseases
Background Alpha-1 antitrypsin (A1AT) is involved in pathophysiology of severe COVID-19, including thrombosis expansion. A1AT has anti-inflammatory, tissue-protective, and anticoagulant capabilities.
Rabab A. Ali, Walaa A. Mohammedsaeed, Mohamed Hisham A. Fakher, Hala K. Noor, Yasir M. Al Qurashi   +4 more
doaj   +2 more sources

Biophysical and Computational Insights into Alpha-1 Antitrypsin Aggregation and Its Inhibition by Natural Polyphenols [PDF]

Biomedicines
Background/Objectives: Protein misfolding and amyloid fibril formation underlie several degenerative diseases, including Alzheimer’s disease and Parkinson’s disease.
Tarique Sarwar, Ahmed Abdur Rehman, Hussain Arif, Wanian M. Alwanian, Hajed Obaid A. Alharbi, Arshad Husain Rahmani   +5 more
doaj   +2 more sources