Results 21 to 30 of about 5,912 (202)

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis [PDF]

, 2020
Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening.
Carreto, Luis, Chalmers, James D., Donovan, Jackie, Fardon, Tom, Finch, Simon, Furrie, Elisabeth, Loebinger, Michael, Morrison, Meghan, Tan, Gan Liang, Wilson, Robert   +9 more
core   +3 more sources

Alpha 1-antitrypsin does not inhibit human monocyte caspase-1. [PDF]

PLoS ONE, 2015
BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune ...
Mohd Akhlakur Rahman, Srabani Mitra, Anasuya Sarkar, Mark D Wewers   +3 more
doaj   +1 more source

Proteoform Profiles Reveal That Alpha-1-Antitrypsin in Human Serum and Milk Is Derived From a Common Source

Frontiers in Molecular Biosciences, 2022
The Alpha-1-Antitrypsin (A1AT) protein is an important protease inhibitor highly abundant in human serum and other body fluids. Additional to functioning as a protease inhibitor, A1AT is an important acute phase protein.
Shelley Jager, Shelley Jager, Dario A. T. Cramer, Dario A. T. Cramer, Max Hoek, Max Hoek, Nadia J. Mokiem, Nadia J. Mokiem, Britt J. van Keulen, Johannes B. van Goudoever, Kelly A. Dingess, Kelly A. Dingess, Kelly A. Dingess, Albert J. R. Heck, Albert J. R. Heck   +14 more
doaj   +1 more source

Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity. [PDF]

PLoS ONE, 2017
Alpha 1-antitrypsin (A1AT) is a serine protease inhibitor that mainly inhibits neutrophil elastase in the lungs. A variant of A1AT at the P1 position with methionine 358 to arginine (A1AT-Pittsburgh) is a rapid inhibitor of thrombin with greatly ...
Hye-Shin Chung, Ji-Sun Kim, Sang Mee Lee, Soon Jae Park   +3 more
doaj   +1 more source

α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils

Molecular Medicine, 2016
Alphal-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and protelnase-3 (PR3), has been proposed to reduce the processing and release of IL-1β.
Nupur Aggarwal, Elena Korenbaum, Ravi Mahadeva, Stephan Immenschuh, Veronika Grau, Charles A Dinarello, Tobias Welte, Sabina Janciauskiene   +7 more
doaj   +1 more source

In Vitro Investigations on Optimizing and Nebulization of IVT-mRNA Formulations for Potential Pulmonary-Based Alpha-1-Antitrypsin Deficiency Treatment

Pharmaceutics, 2021
In vitro-transcribed (IVT) mRNA has come into focus in recent years as a potential therapeutic approach for the treatment of genetic diseases. The nebulized formulations of IVT-mRNA-encoding alpha-1-antitrypsin (A1AT-mRNA) would be a highly acceptable ...
Shan Guan, Max Darmstädter, Chuanfei Xu, Joseph Rosenecker   +3 more
doaj   +1 more source

Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO. [PDF]

PLoS ONE, 2015
The common Z mutation (Glu342Lys) of α1-antitrypsin (A1AT) results in the polymerization and intracellular retention of A1AT protein. The concomitant deficiency of functional A1AT predisposes PiZZ subjects to early onset emphysema.
Janine Koepke, Marc Dresel, Severin Schmid, Timm Greulich, Björn Beutel, Bernd Schmeck, Claus Franz Vogelmeier, Sabina Janciauskiene, Andreas Rembert Koczulla   +8 more
doaj   +1 more source

Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency? [PDF]

, 2017
Differentiating between chronic obstructive pulmonary disease (COPD) patients with normal (PiMM) or deficient (PiZZ) genetic variants of alpha-1 antitrypsin (A1AT) is important not only for understanding the pathobiology of disease progression but also ...
Carleo, Alfonso, Chorostowska-Wynimko, Joanna, Czajkowska-Malinowska, Małgorzata, Janciauskiene, Sabina, Koeck, Thomas, Mischak, Harald, Rozy, Adriana, Welte, Tobias   +7 more
core   +2 more sources

Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease. [PDF]

, 2017
Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced ...
Baye, Fitsum, Goswami, Chirayu Pankaj, Gurung, Ganga, Jackson, Isabel L., Katz, Barry P., Pavlovic, Radmila, Vujaskovic, Zeljko, Winans, Don, Zodda, Andrew   +8 more
core   +4 more sources

SUN-574 A1AT: Novel Inhibitor of Active PCSK9

Journal of the Endocrine Society, 2020
Abstract Heart disease is the principal cause of death and disability for both men and women in the US, accounting for 40% of all annual deaths. African American populations are disproportionately burdened with metabolic diseases, due in part to cholesterol metabolism deficiencies.
Melendez, Quantil, Wooten, Catherine, Ahmed, Sumaira, Williams, Ariel Renee’, Kimbro, Kevin Sean, Lopez, Dayami   +5 more
openaire   +1 more source