Results 11 to 20 of about 3,462 (201)

The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.

Journal of Microbiology and Infectious Diseases, 2019
Alpha one anti-trypsin (A1AT) is a major serine protease inhibitor found circulating in human blood. A1AT related studies mainly focus on A1AT potential biomarker as well as therapeutic target in non-infectious diseases.
Irene Lorinda Indalao, Agustiningsih Agustiningsih, Kartika Dewi Puspa, Eka Pratiwi, Hartanti Dian Ikawati, Ririn Ramadhany   +5 more
doaj   +4 more sources

Alpha1-antitrypsin counteracts heme-induced endothelial cell inflammatory activation, autophagy dysfunction and death

Redox Biology, 2021
Free heme toxicity in the vascular endothelium is critical for the pathogenesis of hemolytic disorders including sickle cell disease. In the current study, it is demonstrated that human alpha1-antitrypsin (A1AT), a serine protease inhibitor with high ...
Kukuh Madyaningrana, Vijith Vijayan, Christoph Nikolin, Abid Aljabri, Srinu Tumpara, Elena Korenbaum, Harshit Shah, Metodi Stankov, Heiko Fuchs, Sabina Janciauskiene, Stephan Immenschuh   +10 more
doaj   +1 more source

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression. [PDF]

PLoS ONE, 2017
The main goal of the therapy with purified human plasma alpha1-antitrypsin (A1AT) is to increase A1AT levels and to prevent lungs from elastolytic activity in patients with PiZZ (Glu342Lys) A1AT deficiency-related emphysema.
Ahmad Karadagi, Helene Johansson, Helen Zemack, Sandeep Salipalli, Lisa-Mari Mörk, Kristina Kannisto, Carl Jorns, Roberto Gramignoli, Stephen Strom, Knut Stokkeland, Bo-Göran Ericzon, Danny Jonigk, Sabina Janciauskiene, Greg Nowak, Ewa C S Ellis   +14 more
doaj   +1 more source

Active trafficking of alpha 1 antitrypsin across the lung endothelium. [PDF]

PLoS ONE, 2014
The homeostatic lung protective effects of alpha-1 antitrypsin (A1AT) may require the transport of circulating proteinase inhibitor across an intact lung endothelial barrier.
Angelia D Lockett, Mary Beth Brown, Nieves Santos-Falcon, Natalia I Rush, Houssam Oueini, Amber J Oberle, Esther Bolanis, Miryam A Fragoso, Daniela N Petrusca, Karina A Serban, Kelly S Schweitzer, Robert G Presson, Michael Campos, Irina Petrache   +13 more
doaj   +1 more source

How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency? [PDF]

PLoS ONE, 2015
The Z deficiency in α1-antitrypsin (A1ATD) is an under-recognized condition. Alpha1-antitrypsin (A1AT) is the main protein in the α1-globulin fraction of serum protein electrophoresis (SPE); however, evaluation of the α1-globulin protein fraction has ...
Ilaria Ferrarotti, Beata Poplawska-Wisniewska, Maria Teresa Trevisan, Janine Koepke, Marc Dresel, Rembert Koczulla, Stefania Ottaviani, Raffaele Baldo, Marina Gorrini, Giorgia Sala, Luana Cavallon, Tobias Welte, Joanna Chorostowska-Wynimko, Maurizio Luisetti, Sabina Janciauskiene   +14 more
doaj   +1 more source

Combination of alpha-1 antitrypsin (A1AT) and anti-TNFα as a neuroprotective strategy in the early stages after ischemic stroke [PDF]

Journal of Cerebral Blood Flow and Metabolism
Paula García-Rodríguez, Laura Ramiro, Alba Simats   +2 more
exaly   +2 more sources

Impact of serine protease inhibitor alpha1-antitrypsin on expression of endoplasmic reticulum stress-induced proinflammatory factors in adipocytes

Biochemistry and Biophysics Reports, 2021
Obesity-induced endoplasmic reticulum (ER) stress contributes to low-grade chronic inflammation in adipose tissue and may cause metabolic disorders such as diabetes mellitus and dyslipidemia.
Yukari Ando, Akito Kuroda, Kazuya Kusama, Takeshi Matsutani, Akihisa Matsuda, Kazuhiro Tamura   +5 more
doaj   +1 more source

Optimal alpha-1 antitrypsin level cutoffs for genotype identification in patients with chronic liver disease

Hepatology Communications, 2023
Background:. Controversy exists whether alpha-1 antitrypsin (A1AT) genotype testing should be performed as a first-line screening for A1AT heterozygous variants. Methods:.
Sameer Prakash, Arvind R. Murali
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Alpha 1-antitrypsin does not inhibit human monocyte caspase-1. [PDF]

PLoS ONE, 2015
BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune ...
Mohd Akhlakur Rahman, Srabani Mitra, Anasuya Sarkar, Mark D Wewers   +3 more
doaj   +1 more source