Results 41 to 50 of about 3,462 (201)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

P90 α-1 antitrypsin (a1AT) polymers cause extreme hepatocyte ageing [PDF]

Gut, 2011
Introduction a1AT, synthesised predominantly in the liver, is the archetypal inhibitor of the serpin protein family. a1AT deficiency is a common inherited disorder; Glu342Lys substitution causes abnormal folding of mutant protein, which may polymerise and aggregate in the endoplasmic reticulum.
M Mela, S Davies, S Verma, P Tachtatzis, E Miranda, D A Lomas, N Coleman, G Alexander   +7 more
openaire   +1 more source

FBG1 decreases A1AT-Z half-life.

, 2015
A) Hepa1-6 cells transfected with A1AT-Z and CMV or FBG1. After cycloheximide treatment, cells were harvested every 2 hours. Cells were lysed, separated on SDS-PAGE gels and probed with anti-A1AT. Shown is representative gel.
Kevin A. Glenn (785982), Katherine N. Gibson-Corley (283085), Hsiang Wen (785981), John H. Wen (785980)   +3 more
core   +1 more source

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency

Frontiers in Molecular Biosciences, 2022
Background: Alpha-1 antitrypsin deficiency (A1ATD) is a progressive lung disease caused by inherited pathogenic variants in the SERPINA1 gene. However, their actual role in maintenance of structural and functional characteristics of the corresponding α-1
Noor Ahmad Shaik, Noor Ahmad Shaik, Najla Bint Saud Al-Saud, Thamer Abdulhamid Aljuhani, Kaiser Jamil, Huda Alnuman, Deema Aljeaid, Nasreen Sultana, Ashraf AbdulRahman El-Harouni, Zuhier Ahmed Awan, Zuhier Ahmed Awan, Ramu Elango, Ramu Elango, Babajan Banaganapalli, Babajan Banaganapalli   +14 more
doaj   +1 more source

Modeling Hereditary Angioedema With Personalized EPSC‐Derived Hepatocytes: A CRISPR‐Validated Platform for Mutation‐Specific Mechanisms and Therapeutic Innovation

Allergy, EarlyView.
Patient‐derived expanded potential stem cell (EPSC) hepatocytes reveal that pathogenic SERPING1 variants cause distinct cellular defects in hereditary angioedema. While most mutations reduce SERPING1 transcription and C1‐INH secretion, a large deletion induces intracellular C1‐INH retention.
Xueyan Liu, Yuxin Wang, Jane C. Y. Wong, Xiang Zhang, Cuixi Wu, Pengyu Chen, Yunzhi Yang, Pentao Liu, Chak Sing Lau, Matthew Cook, Philip Hei Li   +10 more
wiley   +1 more source

Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation

Frontiers in Pharmacology, 2020
Many drugs have been approved for clinical trials for the treatment of COVID-19 disease, focusing on either antiviral or anti-inflammatory approaches. Combining antiviral and anti-inflammatory drugs or therapies together may be more effective.
Chengliang Yang, Shaf Keshavjee, Shaf Keshavjee, Mingyao Liu, Mingyao Liu   +4 more
doaj   +1 more source

Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.

PLoS Genetics, 2021
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in COPD
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach   +15 more
doaj   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

Quantitative analysis of serum A1AT, MMP-9 and MPO.

, 2015
Measurement of (A) A1AT, (C) matrix metalloproteinase 9 (MMP-9) and (E) myeloperoxidase (MPO) levels in serum from augmented and non-augmented PiZZ A1ATpatients.
Marc Dresel (687824), Severin Schmid (340111), Bernd Schmeck (334625), Timm Greulich (340109), Claus Franz Vogelmeier (687826), Sabina Janciauskiene (264288), Andreas Rembert Koczulla (340119), Janine Koepke (687823), Björn Beutel (687825)   +8 more
core   +1 more source

Comparison of serum A1AT, NE, and MPO concentrations in men and women with ALD (Mann-Whitney test)^a.

, 2023
Comparison of serum A1AT, NE, and MPO concentrations in men and women with ALD (Mann-Whitney test)a.
Beata Kasztelan-Szczerbinska (14341418), Halina Cichoz-Lach (3619865), Agata Surdacka (760120), Bartosz Zygo (14341421), Anna Rycyk-Bojarzynska (14341424), Jacek Rolinski (5661685)   +5 more
core   +2 more sources