Results 51 to 60 of about 3,462 (201)
Pulmonary Medicine, 2020 Chronic obstructive pulmonary disease (COPD) is multifactorial disease, which is characterized by airflow limitation and can be provoked by genetic factors, including carriage of the PiZ allele of the protease inhibitor (Pi) gene, encoding alpha-1 ...
Margarita Y. Pervakova +7 more
doaj +1 more source
Transplant Infectious Disease, EarlyView.Among 346 liver transplant recipients, rural residence conferred a 3.3‐fold higher risk of cryptococcal infection — a novel finding suggesting environmental exposure or healthcare access barriers may drive susceptibility. Triple immunosuppression and longer waitlist duration were additional risk factors, with very early infection carrying the worst ...
Rachel Sigler +11 more
wiley +1 more source
FBG1 knockout increases A1AT-Z dPAS accumulation in the mouse liver.
, 2015 FBG1 knockout mice (FBG1 -/-) were crossed with mice with the A1AT-Z transgene (A1AT-Z tg/tg). Livers were harvested from 6 month old mice of FBG1 +/+ A1AT-Z tg/tg (n = 3), FBG1 +/- A1AT-Z tg/0 (n = 6), and FBG1 +/+ A1AT-Z tg/0(n = 3), sectioned and ...
Kevin A. Glenn (785982) +3 more
core +1 more source
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
Mass Spectrometry Reviews, Volume 45, Issue 4, Page 644-671, July/August 2026.ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu +4 more
wiley +1 more source
, 2014 (A) Immunoblot of A1AT from concentrated supernatants showing basolaterally secreted A1AT in endothelial cells co-treated with A1AT (100 µg/mL) and CS or AC extract (2.5%) for up to 120 min (representative blot of n = 3).
Houssam Oueini (553977) +13 more
core +1 more source
Immunological and homeostatic pathways of alpha -1 antitrypsin: a new therapeutic potential
Frontiers in Immunologyα -1 antitrypsin (A1AT) is a 52 kDa acute-phase glycoprotein belonging to the serine protease inhibitor superfamily (SERPIN). It is primarily synthesized by hepatocytes and to a lesser extent by monocytes, macrophages, intestinal epithelial cells, and ...
Carmen Mazzuca +10 more
doaj +1 more source
Scientific Reports, 2021 Based on previous results demonstrating that complexes of a mutant α1-antitrypsin with the heat shock proteins (HSP)70 and glucose-regulated protein94 (Grp94) circulate in the blood of patients with type 1 diabetes, we raised the hypothesis that these ...
Paola Finotti, Andrea Pagetta
doaj +1 more source
Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2
Pathogens and Immunity, 2021 Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease
Nurit P Azouz +11 more
doaj +1 more source
Cells, 2023 Abnormal turnover of the extracellular matrix (ECM) protein elastin has been linked to AMD pathology. Elastin is a critical component of Bruch’s membrane (BrM), an ECM layer that separates the retinal pigment epithelium (RPE) from the underlying ...
Soumya Navneet +3 more
doaj +1 more source
The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet‐Induced and Genetically Obese Mice
Obesity, Volume 34, Issue 6, Page 1300-1313, June 2026.ABSTRACT Objective We aimed to examine the effect of obesity on the plasma free fatty acid (FFA) carrier proteome in mice. Methods From 6 to 20 weeks of age, male and female C57BL/6J wild‐type mice were fed either a low‐fat diet (10% of kilocalories from fat) or a high‐fat diet (60% of kilocalories from fat), and leptin‐deficient ob/ob mice were fed a ...
Keigo Tomoo +3 more
wiley +1 more source