Results 51 to 60 of about 5,912 (202)

Potential of human induced pluripotent stem cells in studies of liver disease. [PDF]

, 2015
Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies ...
Sampaziotis, Fotios, Segeritz, Charis-Patricia, Vallier, Ludovic   +2 more
core   +2 more sources

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency

Frontiers in Molecular Biosciences, 2022
Background: Alpha-1 antitrypsin deficiency (A1ATD) is a progressive lung disease caused by inherited pathogenic variants in the SERPINA1 gene. However, their actual role in maintenance of structural and functional characteristics of the corresponding α-1
Noor Ahmad Shaik, Noor Ahmad Shaik, Najla Bint Saud Al-Saud, Thamer Abdulhamid Aljuhani, Kaiser Jamil, Huda Alnuman, Deema Aljeaid, Nasreen Sultana, Ashraf AbdulRahman El-Harouni, Zuhier Ahmed Awan, Zuhier Ahmed Awan, Ramu Elango, Ramu Elango, Babajan Banaganapalli, Babajan Banaganapalli   +14 more
doaj   +1 more source

The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet‐Induced and Genetically Obese Mice

Obesity, EarlyView.
ABSTRACT Objective We aimed to examine the effect of obesity on the plasma free fatty acid (FFA) carrier proteome in mice. Methods From 6 to 20 weeks of age, male and female C57BL/6J wild‐type mice were fed either a low‐fat diet (10% of kilocalories from fat) or a high‐fat diet (60% of kilocalories from fat), and leptin‐deficient ob/ob mice were fed a ...
Keigo Tomoo, Yi Zhang, Ariana Zoe Diaz Portalatin, Gregory C. Henderson   +3 more
wiley   +1 more source

Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation

Frontiers in Pharmacology, 2020
Many drugs have been approved for clinical trials for the treatment of COVID-19 disease, focusing on either antiviral or anti-inflammatory approaches. Combining antiviral and anti-inflammatory drugs or therapies together may be more effective.
Chengliang Yang, Shaf Keshavjee, Shaf Keshavjee, Mingyao Liu, Mingyao Liu   +4 more
doaj   +1 more source

Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.

PLoS Genetics, 2021
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in COPD
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach   +15 more
doaj   +1 more source

Translating lung function genome-wide association study (GWAS) findings: new insights for lung biology [PDF]

, 2016
Chronic respiratory diseases are a major cause of worldwide mortality and morbidity. Although hereditary severe deficiency of α1 antitrypsin (A1AD) has been established to cause emphysema, A1AD accounts for only ∼1% of Chronic Obstructive Pulmonary ...
Adli, Afonso, Bailey, Baillat, Bannister, Barton, Bellusci, Bentley, Bertin, Bierhaus, Bocchini, Brehm, Brown, Calarco, Castaldi, Castaldi, Celedon, Chappell, Chen, Chen, Cheng, Cho, Cho, Cho, Cho, Ciprandi, Claussnitzer, Conrad, Coultas, Dawkins, Deaton, DeMeo, DeMeo, DeMeo, Dijkstra, Dijkstra, Edwards, Encode Project Consortium, Encode Project Consortium, Eriksson, Ezzeddine, Favorov, Fellermann, Ferhani, Fode, Gaens, Gaj, Gel, Genomes Project Consortium, Gibney, Gilbert, Global Initiative for Chronic Obstructive Lung Disease(GOLD), Gunther, Hackett, Hallberg, Hancock, Hancock, Hankinson, Hansel, Hansen, Hao, Hardin, Hardwick, Heger, Heinz, Hellman, Hemani, Hemminki, Hemminki, Hirschhorn, Hodge, Hofmann, Hollox, Hori, House, Huang da, Hubert, Hughes, Hukkinen, Hunninghake, Hurd, Ingham, International HapMap Consortium, Irving, Ivancso, Janciauskiene, Jin, Joung, Kahai, Kankova, Kho, Kiefer, Kim, Klimentidis, Knight, Konermann, Konermann, Kong, Kwan, Lander, Landt, Latchman, Laurell, Lebecque, Lee, Lee, Lee, Lee, Lewitter, Li, Li, Li, Lieberman, Linton, Loth, Lozano, Luo, Maeder, Maher, Majewski, Mali, Manichaikul, Marchini, Mardis, Masters, Mathers, Maurano, McClearn, McCloskey, Melen, Miller, Miller, Miller, Nicolae, Niden, Obeidat, Obeidat, Obeidat, Ober, Ohno, Palmer, Pearson, Pellegrino, Pepicelli, Perl, Pillai, Pillai, Portelli, Ptashne, Qu, Quinlan, Rabe, Rands, Redline, Repapi, Rockman, Sambamurthy, Sander, Schaub, Shlyueva, Shockett, Silverman, Silverman, Silverman, Simon, Sisson, Smith, Soler Artigas, Soler Artigas, Soler Artigas, Sparvero, Stewart, Stewart, Stogsdill, Stoller, Subramanian, Sun, Syvanen, Tang, Thurman, Uhlen, Van Durme, Venter, Visscher, Wain, Wain, Wang, Wang, Ward, Westra, Wilk, Wilk, Wilk, Wilk, Wilk, Wohlsen, Wu, Xu, Yan, Zhang, Zhou, Zhou, Zhu   +202 more
core   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

High Serum Level of IL-17 in Patients with Chronic Obstructive Pulmonary Disease and the Alpha-1 Antitrypsin PiZ Allele

Pulmonary Medicine, 2020
Chronic obstructive pulmonary disease (COPD) is multifactorial disease, which is characterized by airflow limitation and can be provoked by genetic factors, including carriage of the PiZ allele of the protease inhibitor (Pi) gene, encoding alpha-1 ...
Margarita Y. Pervakova, Alexandra V. Mazing, Sergey V. Lapin, Olga Y. Tkachenko, Anna I. Budkova, Elena A. Surkova, Vladimir L. Emanuel, Olga N. Titova   +7 more
doaj   +1 more source

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source