Results 61 to 70 of about 3,462 (201)

FBG1-mediated degradation of A1AT-Z also occurs through autophagy.

, 2015
A1AT-Z was transfected with FBG1 of pCMV in Hepa1-6 cells. 48 hours later the cells were treated with vehicle (H2O), or autophagy inhibitors for 2.5 hours.
Kevin A. Glenn (785982), Katherine N. Gibson-Corley (283085), Hsiang Wen (785981), John H. Wen (785980)   +3 more
core   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Intravital microscopy of A1AT trafficking across the lung microvascular circulation in the intact mouse.

, 2014
Selected frame from timelapse video of the pulmonary microcirculation following intravenous injections of rhodamine-labeled rat albumin (red) and airspaces (dark) showing no AF488-A1AT (green) prior to injection (pre-A1AT). Note that following AF488-A1AT
Houssam Oueini (553977), Daniela N. Petrusca (553980), Kelly S. Schweitzer (553982), Karina A. Serban (553981), Mary Beth Brown (553974), Miryam A. Fragoso (129475), Irina Petrache (553985), Michael Campos (553984), Robert G. Presson Jr. (553983), Angelia D. Lockett (553973), Nieves Santos-Falcon (553975), Esther Bolanis (553979), Amber J. Oberle (553978), Natalia I. Rush (553976)   +13 more
core   +1 more source

ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis

Veterinary Dermatology, Volume 37, Issue 3, Page 365-374, June 2026.
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake, Melissa P. Swan, Kari J. Ekenstedt   +2 more
wiley   +1 more source

Intracellular trafficking of A1AT to the Golgi system in lung endothelial cells.

, 2014
(A–B) Still frames from time-lapse (10 min) two-photon imaging of A1AT-treated (2 h) lung endothelial cells showing lack of co-localization of labeled A1AT (green) with lysosomal marker, Lysotracker (red; in A), and multiple areas of colocalization (in ...
Houssam Oueini (553977), Daniela N. Petrusca (553980), Kelly S. Schweitzer (553982), Karina A. Serban (553981), Mary Beth Brown (553974), Miryam A. Fragoso (129475), Irina Petrache (553985), Michael Campos (553984), Robert G. Presson Jr. (553983), Angelia D. Lockett (553973), Nieves Santos-Falcon (553975), Esther Bolanis (553979), Amber J. Oberle (553978), Natalia I. Rush (553976)   +13 more
core   +1 more source

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, Volume 37, Issue 3, Page 375-385, June 2026.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

FBG1 immunoprecipitates normal and mutant versions of A1AT.

, 2015
Upper panel: the input came from the total cell lysate of Hepa1-6 cells co-transfected with pCMV or FBG1, and the indicated mixes of A1AT variants. FLAG co-immunoprecipitation (IP) lanes were probed with anti-A1AT that recognizes the M, Z, and K forms of
Kevin A. Glenn (785982), Katherine N. Gibson-Corley (283085), Hsiang Wen (785981), John H. Wen (785980)   +3 more
core   +1 more source

A challenging diagnosis of alpha-1-antitrypsin deficiency: identification of a patient with a novel F/Null phenotype

Allergy, Asthma & Clinical Immunology, 2011
Alpha-1-antitrypsin (A1AT) deficiency is a genetic disease characterized by low levels and/or function of A1AT protein. A1AT deficiency can result in the development of COPD, liver disease, and certain skin conditions.
Ringenbach Michael R, Banta Erin, Snyder Melissa R, Craig Timothy J, Ishmael Faoud T   +4 more
doaj   +1 more source

Large mammal recovery in the wake of human population decline

Journal of Applied Ecology, Volume 63, Issue 5, May 2026.
Human depopulation, particularly in rural areas, has contributed to the recovery of some large mammal populations. While recovery is generally good news for conservation, it can also lead to human‐wildlife conflict. We present several avenues to maximize coexistence in the face of further rural depopulation in other places. Read the free Plain Language
Alex J. Jensen, Benjamin R. Goldstein, Keita Fukasawa, Fabiola Iannarilli, Roland Kays   +4 more
wiley   +1 more source

Cell‐protective mechanisms of alpha 1 antitrypsin (A1AT) in the lung endothelium

The FASEB Journal, 2009
Recent studies uncovered non‐cannonical functions of A1AT that lead to cellular protection from apoptosis and inflammation, including suppression of cigarette smoke (CS)‐induced increases in TNFα. We set out to investigate the mechanisms by which A1AT antagonizes TNFα?in vivo and in primary lung endothelial ...
Angelia Denise Lockett, Jana Garrison, Krzysztof Kamocki, Kelly Schweitzer, Irina Petrache   +4 more
openaire   +1 more source