Results 61 to 70 of about 5,912 (202)

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes [PDF]

, 2014
Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with T1D.
Bornstein, SR, Lam, KSL, Tu, Y, Wang, Y, Xiao, Y, Xu, A, Ye, D, Zhang, J, Zhong, L, Zhou, Z   +9 more
core   +1 more source

Large mammal recovery in the wake of human population decline

Journal of Applied Ecology, Volume 63, Issue 5, May 2026.
Human depopulation, particularly in rural areas, has contributed to the recovery of some large mammal populations. While recovery is generally good news for conservation, it can also lead to human‐wildlife conflict. We present several avenues to maximize coexistence in the face of further rural depopulation in other places. Read the free Plain Language
Alex J. Jensen, Benjamin R. Goldstein, Keita Fukasawa, Fabiola Iannarilli, Roland Kays   +4 more
wiley   +1 more source

A mutant α1antitrypsin in complex with heat shock proteins as the primary antigen in type 1 diabetes in silico investigation

Scientific Reports, 2021
Based on previous results demonstrating that complexes of a mutant α1-antitrypsin with the heat shock proteins (HSP)70 and glucose-regulated protein94 (Grp94) circulate in the blood of patients with type 1 diabetes, we raised the hypothesis that these ...
Paola Finotti, Andrea Pagetta
doaj   +1 more source

Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human

Cells, 2023
Abnormal turnover of the extracellular matrix (ECM) protein elastin has been linked to AMD pathology. Elastin is a critical component of Bruch’s membrane (BrM), an ECM layer that separates the retinal pigment epithelium (RPE) from the underlying ...
Soumya Navneet, Carlene Brandon, Kit Simpson, Bärbel Rohrer   +3 more
doaj   +1 more source

Plasma proteins predict conversion to dementia from prodromal disease. [PDF]

, 2016
PublishedJournal ArticleMulticenter StudyResearch Support, Non-U.S. Gov'tBACKGROUND: The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and ...
Ashton, NJ, Baird, AL, Bazenet, C, Dobson, R, Gauthier, S, Hye, A, Keohane, A, Kłoszewska, I, Leung, R, Lovestone, Simon, Lunnon, Katie, Lupton, MK, Mecocci, P, Pepin, D, Pike, I, Richardson, JC, Riddoch-Contreras, J, Sattlecker, M, Simmons, A, Soininen, H, Tsolaki, M, Tunnicliffe, A, Vellas, B, Ward, M, Westman, E, Zheng, W, Zucht, HD   +26 more
core   +1 more source

Overreliance on Orthographic Similarity in L2‐Japanese Conceptual Processing by L1‐Chinese Learners

International Journal of Applied Linguistics, Volume 36, Issue 2, Page 1807-1820, May 2026.
ABSTRACT Orthographic and phonological similarities between first (L1) and second (L2) languages can facilitate L2 processing. Particularly, L1‐Chinese learners of L2‐Japanese can benefit from the shared morphosyllabic Chinese characters (Japanese kanji/Chinese hanzi) because of their similar orthographies.
Xuehan Zhao, Kexin Xiong, Sachiko Kiyama
wiley   +1 more source

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2

Pathogens and Immunity, 2021
Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease
Nurit P Azouz, Andrea Klingler, Victoria Callahan, Ivan Akhrymuk, Katarina Elez, Lluís Raich, Brandon Henry, Justin Benoit, Stefanie Benoit, Frank Noé, Kylene Kehn-Hall, Marc Rothenberg   +11 more
doaj   +1 more source

Ultracentrifugation and Ultrafiltration Differentially Alter the Composition and Functionality of the Biomolecular Corona of Extracellular Vesicles

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT While extracellular vesicles (EVs) are increasingly recognized for their diagnostic and therapeutic potential, many unknowns remain. An emerging and important concept in EV biology is the EV biomolecular corona, a dynamic layer of absorbed biomolecules to the EV membrane that influences EV behaviour, cellular uptake, biodistribution and ...
Frederic St‐Denis‐Bissonnette, Hala Halabi, Marybeth Creskey, Melanie Kirkby, Xu Zhang, Dylan Burger, Lisheng Wang, Jessie R. Lavoie   +7 more
wiley   +1 more source

Gross Intrahepatic Mass Formation Predicts the Primary Site of Perihilar Cholangiocarcinoma Based on Molecular Pathologic Studies

Journal of Hepato-Biliary-Pancreatic Sciences, Volume 33, Issue 4, Page 284-293, April 2026.
Masuda and colleagues showed that perihilar cholangiocarcinoma near the hilar plate is biologically heterogeneous. Tumors without a gross intrahepatic mass resembled extrahepatic cholangiocarcinoma, whereas those with a gross intrahepatic mass demonstrated an intrahepatic molecular profile, indicating distinct biological subgroups and providing insight
Yuki Masuda, Naoto Kubota, Ryo Takemura, Yasuhito Arai, Yuta Abe, Osamu Itano, Minoru Esaki, Tatsuhiro Shibata, Yuko Kitagawa, Hidenori Ojima   +9 more
wiley   +1 more source

On the smoothness of Levi-foliations [PDF]

, 1988
We study the regularity of the induced foliation of a Levi-flat hypersurface in C'°, showing that the foliation is as many times continuously differentiable as the hypersurface itself. The key step in the proof given here is the construction of a certain
Barrett, D. E., Fornæss, J. E.
core   +2 more sources